Abstract
Background
The pro-inflammatory cytokine interleukin-6 (IL-6) plays a role in cancer development
and progression, but research into the predictive value of IL-6 on postoperative outcome
in soft tissue sarcoma (STS) is scarce. The purpose of this study is to investigate
the predictive value of serum IL-6 level for the achievement of assumed (post)operative
outcome after STS surgery, the so-called textbook outcome.
Methods
Preoperative IL-6 serum levels were collected in all patients with a STS at first
presentation between February 2020 and November 2021. Textbook outcome was defined
as a R0 resection, no complications, no blood transfusions, no reoperation within
the postoperative period, no prolonged hospital stay, no hospital readmission within
90-days, and no mortality within 90-days. Factors associated with textbook outcome
were determined by multivariable analysis.
Results
Among 118 patients with primary, non-metastatic STS, 35.6% achieved a textbook outcome.
Univariate analysis showed that smaller tumor size (p = 0.026), lower tumor grade
(p = 0.006), normal hemoglobin (Hb, p = 0.044), normal white blood cell (WBC) count
(p = 0.018), normal C-reactive protein (CRP) serum level (p = 0.002) and normal IL-6
serum level (p = 1.5 × 10−5) were associated with achieving textbook outcome after surgery. Multivariable analysis
showed that elevated IL-6 serum level (p = 0.012) was significantly associated with
not achieving a textbook outcome.
Conclusions
Increased IL-6 serum level is predictive for not achieving a textbook outcome after
surgery for primary, non-metastatic STS.
Keywords
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Article info
Publication history
Published online: May 03, 2023
Accepted:
May 2,
2023
Received in revised form:
April 14,
2023
Received:
January 18,
2023
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
