Abstract
Introduction
An increased number of children and adolescents with ovarian tumors have been managed
with ovarian-sparing surgery in the last few years. However, comprehensive data on
fertility outcomes and local relapse are scarce. In this study, we systematically
describe the contemporary outcomes of ovarian-sparing surgery, as reported in the
literature.
Materials and methods
Using PRISMA guidelines, we analyzed studies reporting ovarian-sparing techniques
for ovarian tumors in children and adolescents. from 1980 to 2022. Reports with fewer
than three patients, narrative reviews, and opinion articles were excluded. Statistical
analysis was performed for dichotomous and continuous variables.
Results
Of 283 articles screened, 16 papers (3057 patients) met inclusion criteria (15 retrospective/1
prospective) and were analyzed. The vast majority of studies had no long-term fertility
follow-up data and direct comparison between ovarian-sparing surgery vs oophorectomy
was reported in only a few studies. Ovarian sparing surgery was not associated with
worse oncologic outcomes in terms of (i) tumour spillage or (ii) recurrence rates,
and of key importance allowed a higher ovarian reserve at long term follow-up.
Conclusions
Ovarian-sparing surgery is a safe and feasible technique for benign tumors. Long-term
outcome studies are needed to show efficacy and fertility preservation.
Keywords
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Article info
Publication history
Published online: May 17, 2023
Accepted:
April 28,
2023
Received:
January 27,
2023
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
Published by Elsevier Ltd.
