- •Tangential vein resections are not associated with higher rates of local recurrence
- •Long-term outcomes are similar between tangential versus segmental venous resection
- •Tumor features rather than vein resection techniques affect survival outcomes
- •Tangential vein resections are associated with lower postoperative complications
- •Tangential vein resections should be preferred, whenever technically feasible
Few studies analysed the impact of different venous resection techniques on recurrence in patients with pancreatic ductal adenocarcinoma (PDAC). Primary aim was to compare local recurrence rate and disease-free survival (DFS) between patients who underwent pancreatectomy with tangential versus segmental resection of portal vein/superior mesenteric vein.
Materials and methods
All consecutive patients who underwent pancreatectomy with venous resection for PDAC between 2009 and 2019 were included. A propensity score matching (PSM) was used to reduce the effect of treatment selection bias.
Overall, 120 patients (68%) underwent pancreatectomy with tangential venous resection and 57 patients (32%) were submitted to pancreatectomy with segmental venous resection. After a median follow-up of 24 months, local recurrence was comparable between the two groups (tangential: n = 32/120, 26.7% versus segmental: n = 10/57, 17.5%; p = 0.58). The median DFS was 17 months (IQR 9–31) in patients who underwent tangential resection, as compared to 12 months (IQR 5–21) in those who underwent segmental resection (p = 0.049). After PSM (n = 106), the median DFS was 18 months (IQR 9–26) in the tangential resection group, and 12 months (IQR 5–21) in the segmental resection group (p = 0.17). In the PSM population, lymph node ratio (HR 4.83; p = 0.028) and tumor size >25 mm (HR 3.26; p = 0.007) were identified as determinants of local recurrence.
Tangential venous resections are not associated with a higher rate of local recurrence. Long-term outcomes are more related to tumors characteristics than to venous resection techniques. A step-up approach to vein resection, with tangential resection being performed whenever technically feasible, should be strongly encouraged.
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Published online: April 06, 2023
Accepted: March 24, 2023
Received in revised form: February 13, 2023
Received: November 28, 2022
Publication stageIn Press Journal Pre-Proof
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