Abstract
Introduction
Nephron-sparing surgery is the recommended surgical management of T1 renal cell carcinoma
(RCC). However, non-clear cell RCC (nccRCC) is heterogeneous and included many histological
types. Therefore, the present study was performed to compare radical nephrectomy (RN)
versus partial nephrectomy (PN) in nccRCC.
Materials and methods
Within the Surveillance, Epidemiology, and End Results registry (2000–2019), the patients
with nccRCC were identified. Kaplan-Meier survival curve and the log-rank test were
conducted. Univariate analysis and multivariate Cox regression analysis were performed
to explore the prognostic factors.
Results
A total of 7575 patients with nccRCC were included, of which papillary RCC (n = 5219)
is the major histology. Kaplan-Meier plots and log-rank tests showed that nccRCC patients
who underwent RN had significantly worse overall survival (OS) and cancer-specific
survival (CSS) than those who received PN (all P < 0.05). Multivariate analysis also
revealed that RN was significantly associated with poor OS and CSS in nccRCC patients.
Stratified by histological types, the multivariate analysis also revealed that RN
was significantly associated with poor OS in papillary and chromophobe (all P < 0.05).
Besides, the multivariable analysis indicated that RN was associated with poor CSS
in papillary RCC (P < 0.05). For other histology, the patients who received RN had
a comparable survival to those who received PN.
Conclusion
For patients with T1 nccRCC, our findings revealed that PN was not inferior to RN
in OS and CSS. PN may be also the preferred option for T1 nccRCC, but more prospective
studies are required to validate this finding.
Keywords
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Article info
Publication history
Published online: March 16, 2023
Accepted:
March 12,
2023
Received in revised form:
January 22,
2023
Received:
November 24,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
