Abstract
Background
The effect of postoperative complications on long-term quality of life (QoL) is controversial
in abdominal surgery. This study aimed to investigate the impact of 30-day postoperative
complications on long-term QoL after gastrectomy.
Method
This is a longitudinal cohort study that enrolled 908 patients undergoing gastrectomy
for gastric cancer between 2016 and 2017. QoL was assessed using the European Organization
for Research and Treatment of Cancer (EORTC) generic cancer (QLQ C-30) and gastric
module (STO-22) preoperatively and at 1, 6, 12, and 24 months postoperatively. Patients
were divided into the morbidity (30-day postoperative complications) and no-morbidity
groups, and the postoperative QoL change was compared using a linear mixed model.
Results
The mean age was 62.5 ± 12.0 years. Subtotal and total gastrectomy was performed in
763 (84.0%) and 145 (16.0%) patients, respectively. There were 189 (20.8%) patients
developing postoperative complications. The morbidity group showed worse scores in
several functions and symptoms of QoL at the baseline. However, the two groups showed
no significant difference in postoperative changes in most functions and symptoms
of the QLQ C-30 and STO-22 (Pgroup × time > 0.05). The recovery of global health (Pgroup × time < 0.001) and anxiety (Pgroup × time = 0.008) was slightly better in the morbidity group. The subgroup analysis of patients
developing major abdominal complications showed similar results.
Conclusion
The morbidity group showed worse QoL in several functions and symptoms at the baseline.
However, postoperative complications had little influence on QoL change following
gastrectomy for gastric cancer.
Keywords
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Article info
Publication history
Published online: January 17, 2023
Accepted:
January 16,
2023
Received in revised form:
January 2,
2023
Received:
November 30,
2022
Publication stage
In Press Journal Pre-ProofFootnotes
☆This work was supported by the 2022 research fund of the University of Ulsan, South Korea (2022–0453). The funding source had no involvement in conducting the study.
Identification
Copyright
© 2023 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
