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Novel therapeutic inhibitors for oral squamous cell cancer (OSCC) from seaweeds

  • Kamala Kannan
    Affiliations
    Department of Physiology, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, Tamil Nadu, 600077, India
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  • Sivaperumal Pitchiah
    Affiliations
    Marine Biomedical Research Lab & Environmental Toxicology Unit, Department of Prosthodontics, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, Tamil Nadu, 600077, India
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  • Dilipan E
    Affiliations
    Department of Physiology, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, Tamil Nadu, 600077, India
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  • Pasiyappazham Ramasamy
    Correspondence
    Corresponding author. Marine Natural Product Division, Department of Physiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical & Technical Sciences, Saveetha University, Chennai, 600077, Tamil Nadu, India.
    Affiliations
    Department of Physiology, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, Tamil Nadu, 600077, India
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Published:January 17, 2023DOI:https://doi.org/10.1016/j.ejso.2023.01.013
      Oral cancer is one of the most challenging diseases that humanity has to deal with, and despite several advancements in the detection and treatment of oral cancer, it still poses a serious threat to global public health. The majority of oral cancers (96%) are carcinomas, with squamous cell carcinomas making up 91% of all instances. OSCC is one of the major causes of sickness and mortality in South Central Asia and Central and Eastern Europe [
      • Manickam Natarajan Prabhu
      • Rekha Umapathy Vidhya
      • Murali Anita
      • Swamikannu Bhuminathan
      Computational simulations of identified marine-derived natural bioactive compounds as potential inhibitors of oral cancer.
      ]. Therefore, the majority of scientists are interested in novel natural treatments for oral cancer. It has been established that the seaweed is a useful source of biopolymers with unique and different chemical properties that can be used to develop novel treatments with greater potency and specificity.
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