Abstract
Background
The Global Leadership Initiative on Malnutrition released a new version of the malnutrition
criteria (GLIM criteria). To investigate the influence of the GLIM criteria on the
long-term efficacy of radical gastric cancer surgery and establish a nomogram to predict
the long-term prognosis of patients with gastric cancer.
Methods
A retrospective analysis of 1121 patients with gastric cancer in our department from
2010 to 2013 was performed. A nomogram was established to predict overall survival
(OS) based on the GLIM criteria. Patients were divided into the low-risk group (LRG)
and high-risk group (HRG) based on the established nomogram.
Results
Multivariate Cox regression analyses showed that GLIM criteria was an independent
risk factor for the 5-year OS (HR = 1.768, Cl:1.341–2.329, p < 0.001). The C index,
AUC and Time-ROC of the nomogram were significantly better than that of GLIM criteria
and traditional criteria. The 5-year OS of patients receiving adjuvant chemotherapy
in the high-risk group was significantly higher than that of patients without chemotherapy
(45.77% vs. 24.73%,p < 0.001).
Conclusions
The GLIM criteria independently influence the long-term outcome of patients after
radical gastric cancer surgery. The established nomogram can predict the long-term
survival of patients with gastric cancer, and postoperative adjuvant chemotherapy
for HRG can significantly improve the 5-year OS of patients.
Keywords
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Article info
Publication history
Accepted:
January 10,
2023
Received in revised form:
October 26,
2022
Received:
March 8,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 Published by Elsevier Ltd.
