Advertisement

The GLIM criteria as an effective tool for survival prediction in gastric cancer patients

  • Author Footnotes
    1 Zheng HL, Lin J, Shen LL, contributed equally to this work and should be considered co-first author.
    Hua-long Zheng
    Footnotes
    1 Zheng HL, Lin J, Shen LL, contributed equally to this work and should be considered co-first author.
    Affiliations
    Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China

    Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China

    Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China

    Fujian Key Laboratory of Tumor Microbiology, Fujian Medical University, Fuzhou, China
    Search for articles by this author
  • Author Footnotes
    1 Zheng HL, Lin J, Shen LL, contributed equally to this work and should be considered co-first author.
    Jia Lin
    Footnotes
    1 Zheng HL, Lin J, Shen LL, contributed equally to this work and should be considered co-first author.
    Affiliations
    Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China

    Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China

    Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China

    Fujian Key Laboratory of Tumor Microbiology, Fujian Medical University, Fuzhou, China
    Search for articles by this author
  • Author Footnotes
    1 Zheng HL, Lin J, Shen LL, contributed equally to this work and should be considered co-first author.
    Li-li Shen
    Footnotes
    1 Zheng HL, Lin J, Shen LL, contributed equally to this work and should be considered co-first author.
    Affiliations
    Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China

    Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China

    Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China

    Fujian Key Laboratory of Tumor Microbiology, Fujian Medical University, Fuzhou, China
    Search for articles by this author
  • Hai-bo Yang
    Affiliations
    Department of General Surgery, People's Hospital of Guyuan City, Ningxia, China
    Search for articles by this author
  • Bin-bin Xu
    Affiliations
    Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China

    Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China

    Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China

    Fujian Key Laboratory of Tumor Microbiology, Fujian Medical University, Fuzhou, China
    Search for articles by this author
  • Zhen Xue
    Affiliations
    Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China

    Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China

    Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China

    Fujian Key Laboratory of Tumor Microbiology, Fujian Medical University, Fuzhou, China
    Search for articles by this author
  • Dong Wu
    Affiliations
    Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China

    Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China

    Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China

    Fujian Key Laboratory of Tumor Microbiology, Fujian Medical University, Fuzhou, China
    Search for articles by this author
  • Jiao-bao Huang
    Affiliations
    Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China

    Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China

    Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China

    Fujian Key Laboratory of Tumor Microbiology, Fujian Medical University, Fuzhou, China
    Search for articles by this author
  • Guo-sheng Lin
    Affiliations
    Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China

    Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China

    Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China

    Fujian Key Laboratory of Tumor Microbiology, Fujian Medical University, Fuzhou, China
    Search for articles by this author
  • Chao-Hui Zheng
    Affiliations
    Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China

    Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China

    Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China

    Fujian Key Laboratory of Tumor Microbiology, Fujian Medical University, Fuzhou, China
    Search for articles by this author
  • Ping Li
    Affiliations
    Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China

    Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China

    Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China

    Fujian Key Laboratory of Tumor Microbiology, Fujian Medical University, Fuzhou, China
    Search for articles by this author
  • Jian-Wei Xie
    Affiliations
    Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China

    Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China

    Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China

    Fujian Key Laboratory of Tumor Microbiology, Fujian Medical University, Fuzhou, China
    Search for articles by this author
  • Jia-Bin Wang
    Affiliations
    Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China

    Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China

    Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China

    Fujian Key Laboratory of Tumor Microbiology, Fujian Medical University, Fuzhou, China
    Search for articles by this author
  • Jian-Xian Lin
    Affiliations
    Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China

    Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China

    Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China

    Fujian Key Laboratory of Tumor Microbiology, Fujian Medical University, Fuzhou, China
    Search for articles by this author
  • Qi-Yue Chen
    Affiliations
    Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China

    Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China

    Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China

    Fujian Key Laboratory of Tumor Microbiology, Fujian Medical University, Fuzhou, China
    Search for articles by this author
  • Long-Long Cao
    Affiliations
    Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China

    Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China

    Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China

    Fujian Key Laboratory of Tumor Microbiology, Fujian Medical University, Fuzhou, China
    Search for articles by this author
  • Jun Lu
    Correspondence
    Corresponding author. Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
    Affiliations
    Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China

    Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China

    Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China

    Fujian Key Laboratory of Tumor Microbiology, Fujian Medical University, Fuzhou, China
    Search for articles by this author
  • Chang-Ming Huang
    Correspondence
    Corresponding author. Department of Gastric Surgery, Fujian Medical University Union Hospital, No.29 Xinquan Road, Fuzhou, 350001, Fujian Province, China
    Affiliations
    Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China

    Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou, China

    Key Laboratory of Ministry of Education of Gastrointestinal Cancer, Fujian Medical University, Fuzhou, China

    Fujian Key Laboratory of Tumor Microbiology, Fujian Medical University, Fuzhou, China
    Search for articles by this author
  • Author Footnotes
    1 Zheng HL, Lin J, Shen LL, contributed equally to this work and should be considered co-first author.
Published:January 11, 2023DOI:https://doi.org/10.1016/j.ejso.2023.01.009

      Abstract

      Background

      The Global Leadership Initiative on Malnutrition released a new version of the malnutrition criteria (GLIM criteria). To investigate the influence of the GLIM criteria on the long-term efficacy of radical gastric cancer surgery and establish a nomogram to predict the long-term prognosis of patients with gastric cancer.

      Methods

      A retrospective analysis of 1121 patients with gastric cancer in our department from 2010 to 2013 was performed. A nomogram was established to predict overall survival (OS) based on the GLIM criteria. Patients were divided into the low-risk group (LRG) and high-risk group (HRG) based on the established nomogram.

      Results

      Multivariate Cox regression analyses showed that GLIM criteria was an independent risk factor for the 5-year OS (HR = 1.768, Cl:1.341–2.329, p < 0.001). The C index, AUC and Time-ROC of the nomogram were significantly better than that of GLIM criteria and traditional criteria. The 5-year OS of patients receiving adjuvant chemotherapy in the high-risk group was significantly higher than that of patients without chemotherapy (45.77% vs. 24.73%,p < 0.001).

      Conclusions

      The GLIM criteria independently influence the long-term outcome of patients after radical gastric cancer surgery. The established nomogram can predict the long-term survival of patients with gastric cancer, and postoperative adjuvant chemotherapy for HRG can significantly improve the 5-year OS of patients.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to European Journal of Surgical Oncology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Torre Lindsey A.
        • Freddie Bray
        • Siegel Rebecca L.
        • et al.
        Global cancer statistics.
        Ca - Cancer J Clin. 2012; 65 (2015): 87-108
        • Jacqueline Braga da Silva
        • Fernandes Maurício Sílvia
        • Tatiana Bering
        • et al.
        The relationship between nutritional status and the Glasgow prognostic score in patients with cancer of the esophagus and stomach.
        Nutr Cancer. 2013; 65: 25-33
        • Witvliet-van Nierop J.E.
        • Lochtenberg-Potjes C.M.
        • Wierdsma N.J.
        • et al.
        Assessment of nutritional status, digestion and absorption, and quality of life in patients with locally advanced pancreatic cancer.
        Gastroenterol Res Pract. 2017; 20176193765
        • Choi Wook Jin
        • Kim Jeongseon
        Nutritional care of gastric cancer patients with clinical outcomes and complications: a review.[J].
        Clin Nutr Res. 2016; 5: 65-78
        • von Meyenfeldt Maarten
        Cancer-associated malnutrition: an introduction. null. Eur J Oncol Nurs, 2005: S35-S38
        • Cederholm T.
        • Bosaeus I.
        • Barazzoni R.
        • et al.
        Diagnostic criteria for malnutrition - an ESPEN consensus statement.
        Clin Nutr. 2015; 34: 335-340
        • Ricardo Marinho
        • Pessoa Ana
        • Marta Lopes
        • et al.
        High prevalence of malnutrition in Internal Medicine wards - a multicentre ANUMEDI study.
        Eur J Intern Med. 2020; 76: 82-88
        • Ricardo Marinho
        • Pessoa Ana
        • Marta Lopes
        • et al.
        High prevalence of malnutrition in Internal Medicine wards - a multicentre ANUMEDI study.
        Eur J Intern Med. 2020; 76: 82-88
        • Cederholm T.
        • Jensen G.L.
        • Correia M.I.T.D.
        • et al.
        GLIM criteria for the diagnosis of malnutrition - a consensus report from the global clinical nutrition community.
        J Cachexia Sarcopenia Muscle. 2019; 10: 207-217
        • Mariana Abe Vicente
        • Katia Barão
        • Donizetti Silva Tiago
        • et al.
        What are the most effective methods for assessment of nutritional status in outpatients with gastric and colorectal cancer?.
        Nutr Hosp. 2013; 28: 585-591
        • Tegels Juul J.W.
        • de Maat M.F.G.
        • Hulsewé K.W.E.
        • et al.
        Value of geriatric frailty and nutritional status assessment in predicting postoperative mortality in gastric cancer surgery.
        J Gastrointest Surg. 2014; 18 (; discussion 445-6): 439-445
        • Zheng Hua-Long
        • Lu Jun
        • Li Ping
        • et al.
        Effects of preoperative malnutrition on short- and long-term outcomes of patients with gastric cancer: can we do better?.
        Ann Surg Oncol. 2017; 24: 3376-3385
        • Amin M.B.
        • Edge S.B.
        • Greene F.L.
        • et al.
        AJCC cancer staging manual.
        eighth ed. Springer, New York2017
      1. Japanese gastric cancer treatment guidelines 2014 (ver. 4).
        Gastric Cancer. 2017; 20: 1-19
        • Lu Jun
        • Chao-Hui Zheng
        • Xu Bin-Bin
        • et al.
        Assessment of robotic versus laparoscopic distal gastrectomy for gastric cancer: a randomized controlled trial.
        Ann Surg. 2021; 273: 858-867
        • Daniel Dindo
        • Nicolas Demartines
        • Pierre-Alain Clavien
        Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey.
        Ann Surg. 2004; 240: 205-213
        • Ju-Hee Lee
        • Park Do Joong
        • Hyung-Ho Kim
        • et al.
        Comparison of complications after laparoscopy-assisted distal gastrectomy and open distal gastrectomy for gastric cancer using the Clavien-Dindo classification.
        Surg Endosc. 2012; 26: 1287-1295
        • Daniel Dindo
        • Nicolas Demartines
        • Pierre-Alain Clavien
        Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey.
        Ann Surg. 2004; 240: 205-213
        • Ju-Hee Lee
        • Park Do Joong
        • Hyung-Ho Kim
        • et al.
        Comparison of complications after laparoscopy-assisted distal gastrectomy and open distal gastrectomy for gastric cancer using the Clavien-Dindo classification.
        Surg Endosc. 2012; 26: 1287-1295
        • Han Dong-Seok
        • Yun-Suhk Suh
        • Kong Seong-Ho
        • et al.
        Nomogram predicting long-term survival after d2 gastrectomy for gastric cancer.
        J Clin Oncol. 2012; 30: 3834-3840
        • Jiang Yuming
        • Li Tuanjie
        • Liang Xiaoling
        • et al.
        Association of adjuvant chemotherapy with survival in patients with stage II or III gastric cancer.
        JAMA Surg. 2017; 152e171087
        • Hirabayashi S.
        • Kosugi S.
        • Isobe Y.
        • et al.
        Development and external validation of a nomogram for overall survival after curative resection in serosa-negative, locally advanced gastric cancer.
        Ann Oncol. 2014; 25: 1179-1184
        • Akazawa K.
        • Nakamura T.
        • Palesch Y.
        Power of logrank test and Cox regression model in clinical trials with heterogeneous samples.
        Stat Med. 1997; 16: 583-597
        • Camp Robert L.
        • Rimm David L.
        • Dolled-Filhart Marisa
        X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization.
        Clin Cancer Res. 2004; 10: 7252-7259
        • Oertelt-Prigione Sabine
        • de Rooij Belle H.
        • Floortje Mols
        • et al.
        Sex-differences in symptoms and functioning in >5000 cancer survivors: results from the PROFILES registry.
        Eur J Cancer. 2021; 156: 24-34
        • Hammerlid E.
        • Taft C.
        Health-related quality of life in long-term head and neck cancer survivors: a comparison with general population norms.
        Br J Cancer. 2001; 84: 149-156
        • Donini Lorenzo M.
        • Eleonora Poggiogalle
        • Alessio Molfino
        • et al.
        Mini-nutritional assessment, malnutrition universal screening tool, and nutrition risk screening tool for the nutritional evaluation of older nursing home residents.
        J Am Med Dir Assoc. 2016; 17 (959.e11-959.e18)
        • Leistra E.
        • Langius J.A.E.
        • Evers A.M.
        • et al.
        Validity of nutritional screening with MUST and SNAQ in hospital outpatients.[J].
        Eur J Clin Nutr. 2013; 67: 738-742
        • Bistrian B.R.
        • Blackburn G.L.
        • Vitale J.
        • et al.
        Prevalence of malnutrition in general medical patients.
        JAMA. 1976; 235: 1567-1570
        • Zhang Xi
        • Tang Meng
        • Zhang Qi
        • et al.
        The GLIM criteria as an effective tool for nutrition assessment and survival prediction in older adult cancer patients.
        Clin Nutr. 2021; 40: 1224-1232
        • Maeda Keisuke
        • Ishida Yuria
        • Tomoyuki Nonogaki
        • et al.
        Reference body mass index values and the prevalence of malnutrition according to the Global Leadership Initiative on Malnutrition criteria.
        Clin Nutr. 2020; 39: 180-184
        • Baker J.P.
        • Detsky A.S.
        • Wesson D.E.
        • et al.
        Nutritional assessment: a comparison of clinical judgement and objective measurements.
        N Engl J Med. 1982; 306: 969-972
        • Guigoz Y.
        • Vellas B.
        • Garry P.J.
        Assessing the nutritional status of the elderly: the Mini Nutritional Assessment as part of the geriatric evaluation.
        Nutr Rev. 1996; 54: S59-S65
        • Jens Kondrup
        • Højgaard Rasmussen Henrik
        • Ole Hamberg
        • et al.
        Nutritional risk screening (NRS 2002): a new method based on an analysis of controlled clinical trials.
        Clin Nutr. 2003; 22: 321-336
        • Veterans Affairs Total Parenteral Nutrition Cooperative Study Group
        Perioperative total parenteral nutrition in surgical patients.
        N Engl J Med. 1991; 325: 525-532
        • Abe Vicente Mariana
        • Barão Katia
        • Silva Tiago Donizetti
        • et al.
        What are the most effective methods for assessment of nutritional status in outpatients with gastric and colorectal cancer?.
        Nutr Hosp. 2013; 28: 585-591
        • Mariana Raslan
        • Cristina Gonzalez Maria
        • Torrinhas Raquel Suzana M.M.
        • et al.
        Complementarity of subjective global assessment (SGA) and nutritional risk screening 2002 (NRS 2002) for predicting poor clinical outcomes in hospitalized patients.
        Clin Nutr. 2011; 30: 49-53
        • Abbott Jessica
        • Teleni L.
        • McKavanagh D.
        • et al.
        Patient-Generated Subjective Global Assessment Short Form (PG-SGA SF) is a valid screening tool in chemotherapy outpatients.
        Support Care Cancer. 2016; 24: 3883-3887
        • Yilmaz Merve
        • Fahri Sahin
        • et al.
        • Atilla Fatos Dilan
        The effect of malnutrition on mortality in hospitalized patients with hematologic malignancy.
        Support Care Cancer. 2020; 28: 1441-1448
        • Zhou Zhangjian
        • Zhang Hao
        • Xu Zisen
        • et al.
        Nomogram predicted survival of patients with adenocarcinoma of esophagogastric junction.
        World J Surg Oncol. 2015; 13: 197
        • Kattan Michael W.
        • Mithat Gönen
        • Jarnagin William R.
        • et al.
        A nomogram for predicting disease-specific survival after hepatic resection for metastatic colorectal cancer.
        Ann Surg. 2008; 247: 282-287
        • Matsuda Naoko
        • Hayashi Naoki
        • Sachiko Ohde
        • et al.
        A nomogram for predicting locoregional recurrence in primary breast cancer patients who received breast-conserving surgery after neoadjuvant chemotherapy.
        J Surg Oncol. 2014; 109: 764-769
        • Chen Kai
        • Su Fengxi
        • Jacobs Lisa K.
        A nomogram to predict the benefit of radiation therapy after breast-conserving surgery in elderly patients with stage I & ER-negative, or stage II/III disease.
        Ann Surg Oncol. 2015; 22: 3497-3503
        • Lagarde S.M.
        • Reitsma J.B.
        • de Castro S.M.M.
        • et al.
        Prognostic nomogram for patients undergoing oesophagectomy for adenocarcinoma of the oesophagus or gastro-oesophageal junction.
        Br J Surg. 2007; 94: 1361-1368
        • Zhang Qi
        • Zhang Kang-Ping
        • Zhang Xi
        • et al.
        Scored-GLIM as an effective tool to assess nutrition status and predict survival in patients with cancer.
        Clin Nutr, 2021 ([undefined: undefined])
        • Wang Jiping
        • Dang Ping
        • Raut Chandrajit P.
        • et al.
        Comparison of a lymph node ratio-based staging system with the 7th AJCC system for gastric cancer: analysis of 18,043 patients from the SEER database.
        Ann Surg. 2012; 255: 478-485
        • Susanna Cunningham-Rundles
        • McNeeley David F.
        • Moon Aeri
        Mechanisms of nutrient modulation of the immune response.
        J Allergy Clin Immunol. 2005; 115 (; quiz 1129): 1119-1128
        • Schwegler I.
        • von Holzen A.
        • Gutzwiller J.-P.
        • et al.
        Nutritional risk is a clinical predictor of postoperative mortality and morbidity in surgery for colorectal cancer.
        Br J Surg. 2010; 97: 92-97
        • Dong-Dong Huang
        • Yu Ding-Ye
        • Song Hao-Nan
        • et al.
        The relationship between the GLIM-defined malnutrition, body composition and functional parameters, and clinical outcomes in elderly patients undergoing radical gastrectomy for gastric cancer.
        Eur J Surg Oncol. 2021; 47: 2323-2331
        • Sung Hoon Noh
        • Sook Ryun Park
        • Han-Kwang Yang
        • et al.
        Adjuvant capecitabine plus oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): 5-year follow-up of an open-label, randomised phase 3 trial.[J].
        Lancet Oncol. 2014; 15: 1389-1396
        • Shinichi Sakuramoto
        • Mitsuru Sasako
        • Yamaguchi Toshiharu
        • et al.
        Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine.
        N Engl J Med. 2007; 357: 1810-1820
        • Liu Xuechao
        • Zhang Deyao
        • Lin Enzi
        • et al.
        Preoperative controlling nutritional status (CONUT) score as a predictor of long-term outcome after curative resection followed by adjuvant chemotherapy in stage II-III gastric Cancer.
        BMC Cancer. 2018; 18: 699
        • Tsilimigras Diamantis I.
        • Hyer J Madison
        • Paredes Anghela Z.
        • et al.
        Tumor burden dictates prognosis among patients undergoing resection of intrahepatic cholangiocarcinoma: a tool to guide post-resection adjuvant chemotherapy?.
        Ann Surg Oncol. 2021; 28: 1970-1978