Abstract
Introduction
Recently, the number of diagnosed esophageal basaloid squamous cell carcinoma (EBSCC)
has gradually increased. However, available data on EBSCC are limited to date.
Methods
A total of 165 EBSCC (Cohort 1) and 515 conventional esophageal squamous cell carcinoma
(ESCC) (Cohort 2) were retrospectively analyzed.
Results
In Cohort 1, 70 cases only had invasive EBSCC component (42.4%, defined as Group 1),
73 cases had concomitant invasive ESCC component (44.2%, Group 2), and 22 had concomitant
invasive poor-differentiated component (13.3%, Group 3). Lymph node metastasis rates
of Group 3, Group 2 and Group 1 were ranked from high to low (P = 0.044). There were higher patient age (P = 0.047), smaller tumor size (P = 0.009), more nerve invasion (P < 0.001), and lower pTNM stage (P < 0.001) in EBSCC (Cohort 1), compared with ESCC (Cohort 2). In Cohort 1 and Cohort
2, pTNM stage was an independent prognostic factor for both DFS and OS. No significant
survival difference was found between EBSCC (Cohort 1) and ESCC (Cohort 2) in pIA-B
stage, pIIA-B stage, pIIIA-B stage and pIVA-B stage (P > 0.05).
Conclusion
Our analysis of the largest EBSCC series from a single institution to date with conventional
ESCC demonstrated that EBSCC carried a similar prognosis with ESCC in pIA-B stage,
pIIA-B stage, pIIIA-B stage and pIVA-B stage. And pure EBSCC, didn't have poorer survival
than mixed EBSCC with concomitant ESCC or other components. Our findings may be valuable
in the better understanding of EBSCC's biological behaviors, and the related molecular
mechanism is needed to be explored in the future.
Keywords
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Article info
Publication history
Published online: December 26, 2022
Accepted:
December 24,
2022
Received in revised form:
November 17,
2022
Received:
July 21,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 Published by Elsevier Ltd.
