Abstract
Background
For Ductal Carcinoma in Situ (DCIS), recurrence is shown to be higher after skin-sparing
(SSM) versus simple (SM) mastectomy. This study aimed to compare the two groups recurrence
rates, disease-free survival (DFS), and overall (OS) survival.
Methods
We conducted a retrospective register-based cohort study of women operated with SSM
(n = 338) or SM (n = 238) for DCIS between 2007 and 2017. Data from the Norwegian
Breast Cancer Registry was used to estimate recurrences rates, DFS and OS.
Results
Mean age was 51 and 61 years in the SSM and SM groups, respectively. Median follow-up
time was 77 months for SSM (range: 21–152 months) vs 84 months for SM (range: 7–171
months). After five years of follow-up, the overall recurrence rate (OR) was 2.1%;
3.9% for SSM and 0.9% for SM. After ten years, the rates were 3.0%, 6.2% for SSM and
still 0.9% for SM. DFS was after ten years 92.2%; 91.8% for SSM, and 92.4% for SM.
OS was 95.0%; 97.5% for SSM and 93.3% for SM at ten years. For SSM, involved margins
represented a significant risk for recurrence.
Conclusion
The recurrence rate was higher in the SSM versus the SM group. Whether the difference
is due to the operating procedures or underlying risk factors remains unknown. When
stratifying for the difference in age, there was no statistical difference in DFS
or OS. Involved margins in the SSM group were associated with an increased risk of
recurrence.
Keywords
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Article info
Publication history
Published online: November 30, 2022
Accepted:
November 30,
2022
Received in revised form:
November 18,
2022
Received:
August 25,
2022
Identification
Copyright
© 2022 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
