Research Article| Volume 49, ISSUE 6, P1081-1090, June 2023

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Current management of benign retroperitoneal tumors

  • Fabio Tirotta
    Department of Sarcoma and General Surgery, Midlands Abdominal and Retroperitoneal Sarcoma Unit, University Hospital Birmingham NHS Foundation Trust, Birmingham, United Kingdom
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  • Andrea Napolitano
    Sarcoma Unit, The Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom
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  • Sangkyu Noh
    Division of Surgical Oncology, Department of Surgery, Moores Cancer Center, University of California, UC San Diego Health Sciences, 3855 Health Sciences Drive, Room 2313, Mail Code 0987, La Jolla, San Dieg, CA, 92093-0987, USA

    College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA, 91766-1854, USA
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  • Erika Schmitz
    Department of Surgery, The Ottawa Hospital and Research Institute, University of Ottawa, Ottawa, Ontario, Canada
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  • Carolyn Nessim
    Department of Surgery, The Ottawa Hospital and Research Institute, University of Ottawa, Ottawa, Ontario, Canada
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  • Dakshesh Patel
    Department of Radiology, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA
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  • Jason K. Sicklick
    Division of Surgical Oncology, Department of Surgery, Moores Cancer Center, University of California, UC San Diego Health Sciences, 3855 Health Sciences Drive, Room 2313, Mail Code 0987, La Jolla, San Dieg, CA, 92093-0987, USA
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  • Myles Smith
    Sarcoma Unit, The Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom
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  • Khin Thway
    Department of Pathology, The Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom
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  • Jos van der Hage
    Department of Surgery, Leiden University Medical Center, Leiden, Netherlands
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  • Samuel J. Ford
    Corresponding author. Department of Sarcoma and General Surgery, Midlands Abdominal and Retroperitoneal Sarcoma Unit, University Hospital Birmingham NHS Foundation Trust, Mindelsohn Way, Birmingham, B15 2TH, UK.
    Department of Sarcoma and General Surgery, Midlands Abdominal and Retroperitoneal Sarcoma Unit, University Hospital Birmingham NHS Foundation Trust, Birmingham, United Kingdom
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  • William W. Tseng
    Corresponding author. Division of Surgical Onocology, Department of Surgery, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA, 91010, USA.
    Division of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, Duarte, CA, USA
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      Benign retroperitoneal tumors (BRT) represent a rare group of heterogeneous diseases. The literature lacks high-quality evidence about the optimal management of BRT, and most of the information available takes the form of case reports or case series. The aim of this review is to provide an overview of current management strategies for adult patients with BRT.
      A literature search using PubMed indexed articles was conducted and BRT were classified into five different biological subgroups: 1) lipomatous tumors, 2) smooth muscle tumors, 3) peripheral nerve sheath tumors, 4) myofibroblastic tumors, and 5) others. Tumors that are primarily pelvic in origin were excluded.
      Despite the significant heterogeneity of the disease, several generic considerations have emerged and can be applied to the management of BRT. Specifically, the risk of misdiagnosing a BRT with another pathology such as retroperitoneal sarcoma is notable. When encountered, suspected BRT should therefore be referred to a specialized sarcoma center. Multidisciplinary tumor boards, present at these centers, have a pivotal role in managing BRT. The decision of whether to offer surgery, nonsurgical treatment or a “watch-and-wait” approach should be made after multidisciplinary discussion, depending on tumor histology. Moving forward, collaborative research efforts dedicated to BRT remain crucial in gathering evidence and knowledge to further optimize patient care.


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