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Prevalence and incidence of pseudomyxoma peritonei in urban China: A nationwide retrospective cohort study

  • Author Footnotes
    1 Contributed equally as joint first authors.
    Jing-Nan Feng
    Footnotes
    1 Contributed equally as joint first authors.
    Affiliations
    Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, China
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  • Author Footnotes
    1 Contributed equally as joint first authors.
    A-Jin Hu
    Footnotes
    1 Contributed equally as joint first authors.
    Affiliations
    Department of Pathology, Peking University Third Hospital, Beijing, 100191, China
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  • Lu Xu
    Affiliations
    Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, China
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  • Li-Li Liu
    Affiliations
    Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, China
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  • Guo-Zhen Liu
    Affiliations
    Peking University Health Information Technology Co. Ltd, Beijing, 100080, China
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  • Jin-Xi Wang
    Affiliations
    Shanghai Songsheng Business Consulting Co. LTD, Beijing, 100000, China
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  • Pei Gao
    Affiliations
    Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, China
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  • Cong-Rong Liu
    Correspondence
    Corresponding author. Department of Pathology, Third Hospital, School of Basic Medical Sciences, Peking University Health Science Center, No.49, North Garden Rd, Haidian District Beijing, PR China.
    Affiliations
    Department of Pathology, Third Hospital, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100191, China
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  • Sheng-Feng Wang
    Correspondence
    Corresponding author. Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, No.38, Xueyuan Rd, Haidian District, Beijing, PR China.
    Affiliations
    Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, China
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  • Si-Yan Zhan
    Correspondence
    Corresponding author. Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, No.38, Xueyuan Rd, Haidian District, Beijing, PR China.
    Affiliations
    Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, China

    Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing, 100191, China

    Institute for Artificial Intelligence, Peking University, Beijing, 100091, China
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  • Author Footnotes
    1 Contributed equally as joint first authors.

      Abstract

      Background

      Pseudomyxoma peritonei (PMP) is an extremely rare condition. Information regarding the disease burden of PMP in developing countries is limited. This study aimed to determine the epidemiology of PMP in China.

      Methods

      PMP data were extracted from the national databases of Urban Basic Medical Insurance. All cases were identified using the International Classification of Diseases (ICD) codes and Chinese diagnostic terms. The national prevalence from 2012 to 2016 and incidence in 2016 were estimated.

      Results

      In total, 153 patients with PMP were identified. The crude prevalence of PMP in 2016 was 2.47 (95% confidence interval [CI] 1.71 to 3.23) per million person-year, with a higher prevalence in females than males. Prevalence increased with age, with the first peak in those aged 15–29 years and the highest in those aged >80 years. The crude incidence of PMP in 2016 was 1.19 (95% CI 0.59 to 1.78) per million person-years. Similar to the prevalence, the rates were higher in women than in men. The incidence also increased with age, with the highest prevalence in those aged >80 years. Besides, the most frequent comorbidities before and after the first diagnosis of PMP were unspecified secondary malignancies and malignancies of unspecified sites, followed by abdominal malignant tumours.

      Conclusions

      The rate of PMP was lower in mainland China than in European countries and increased with advancing age. Women were more likely to have PMP than men. Furthermore, an insufficient understanding of this rare disease presents a major challenge in accurately evaluating the disease burden.

      Keywords

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