An article by Hoffman and Ashkenazi has been recently published in European Journal of Surgical Oncology, regarding the impact of MarginProbe in the evaluation of resection margins in breast conserving surgery, which we read with great interest [
]. The authors utilised MarginProbe to evaluate the status of a series of 302 resection margins during lumpectomies, corresponding to 51 tumours and 48 patients and compared their results with the final pathological analysis. Of them, 13 margins were considered positive by pathological evaluation (tumour cells adjacent within 1 mm or less to the inked surface) and MarginProbe was successfully evaluated 3 out 13 these margins as positive. In addition, out of 289 confirmed negative margins (uninvolved during pathological evaluation), MarginProbe evaluated 97 as potentially positive. Overall, the sensitivity and specificity of MarginProbe has been calculated as 23.1% and 66.4%, respectively.
- Hoffman A.
- Ashkenazi I.
The efficiency of MarginProbe in detecting positive resection margins in epithelial breast cancer following breast conserving surgery.
Eur J Surg Oncol. 2022; https://doi.org/10.1016/j.ejso.2022.02.021
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- The efficiency of MarginProbe in detecting positive resection margins in epithelial breast cancer following breast conserving surgery.Eur J Surg Oncol. 2022; https://doi.org/10.1016/j.ejso.2022.02.021
- Society of Surgical Oncology–American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer.Int J Radiat Oncol Biol Phys. 2014; 88: 553-564
- Rapid assessment of resection margins during breast conserving surgery using intraoperative flow cytometry.Clin Breast Cancer. 2021; 21: e602-e610https://doi.org/10.1016/j.clbc.2021.03.002
- The past, present and future of flow cytometry in central nervous system malignancies.Methods Protoc. 2021; 4https://doi.org/10.3390/mps4010011
Published online: April 20, 2022
Accepted: April 11, 2022
Received: March 22, 2022
© 2022 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
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- Reply to: Next-generation margin evaluation techniques in breast conserving surgery: A memorandum on intraoperative flow cytometryEuropean Journal of Surgical OncologyVol. 48Issue 6
- PreviewThank you for sharing the results of Vartholomatos et al., who used intraoperative flow cytometry (iFC) and demonstrated very high sensitivity and specificity rates in identifying neoplastic cells in a given lumpectomy specimen margin . Achieving clear lumpectomy margins is necessary to avoid the need for reoperation and to diminish the rates of ipsilateral breast recurrences. Several approaches and technologies have been suggested to lower the rates of involved/close margins. Yet, none have proved superior to others, and the search for an optimal method continues .