Abstract
Background
Colorectal carcinoma (CRC) has a worldwide incidence of 1.4 million patients and a
large share in cancer-related mortality. After curative treatment, the risk of recurrence
is 30–65%. Early detection may result in curative treatment. However, current follow-up
(FU) examinations have low sensitivity ranging from 49 to 85% and are associated with
high costs. Therefore, the search for a new diagnostic tool is justified. Analysis
of volatile organic compound in exhaled air through an electronic nose (eNose) is
a promising new patient-friendly diagnostic tool. We studied whether the eNose under
investigation, the Aeonose™, is able to detect local recurrence or metastases of CRC.
Methods
In this cross-sectional study we included 62 patients, all of whom underwent curative
treatment for CRC in the past 5 years. Thirty-six of them had no metastases and 26
had extraluminal local recurrence or metastases of CRC, detected during FU. Breath
testing was performed and machine learning was used to predict extraluminal recurrences
or metastases, and based on the receiver operating characteristics (ROC)-curve both
sensitivity and specificity were calculated.
Results
The eNose identified extra luminal local recurrences or metastases of CRC with a sensitivity
and specificity of 0.88 (CI 0.69–0.97) and 0.75 (CI 0.57–0.87), respectively, with
an overall accuracy of 0.81.
Discussion
This eNose may be a promising tool in detecting extraluminal local recurrences or
metastases in the FU of curatively treated CRC. However, a well-designed prospective
study is warranted to show its accuracy and predictive value before it can be used
in clinical practice.
Keywords
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Article info
Publication history
Published online: July 24, 2020
Accepted:
July 19,
2020
Identification
Copyright
© 2020 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
