Abstract
Background
Women with impalpable or poorly palpable breast cancer require radiologically guided
localisation prior to breast conserving surgery. Radioguided Occult Lesion Localisation
using Iodine-125 Seed (ROLLIS) is an emerging alternative to conventional Hookwire
Localisation (HWL). We compared ROLLIS with conventional HWL with respect to patient
reported stress and discomfort related to the localisation procedure.
Patients and methods
From September 2013 to January 2016, women who were eligible for breast conserving
surgery with impalpable or poorly palpable histologically confirmed invasive or in-situ
carcinoma were recruited to the multi-centre ROLLIS randomised controlled trial and
underwent either ROLLIS or HWL. Following surgery, a questionnaire was administered
to each participant regarding the stress and discomfort related to the localisation
procedure. Multivariate analysis was performed to compare the primary outcome of patient-reported
stress and discomfort between localisation groups.
Results
218 participants with 220 lesions were randomised and underwent breast conserving
surgery following localisation. 201 (92.2%) and 202 (92.7%) of participants provided
responses to the stress and discomfort components of the questionnaire respectively.
HWL was associated with a statistically significant increased odds of greater stress
and discomfort when compared to ROLLIS (OR = 2.07, p = 0.01 and OR = 1.94, p = 0.01
respectively). Insertion of multiple localisation devices was also associated with
increased stress (OR = 5.68, p < 0.01) and discomfort (OR = 2.96, p < 0.01).
Conclusion
When compared with conventional HWL, ROLLIS is associated with significantly less
stress and discomfort for patients prior to breast conserving surgery.
Keywords
Abbreviations:
ROLLIS (Radioguided Occult Lesion Localisation using Iodine-125 Seed), HWL (Hookwire Localisation)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: October 16, 2017
Accepted:
September 13,
2017
Identification
Copyright
Crown Copyright © 2017 Published by Elsevier Ltd. All rights reserved.
