The NeuroSAFE PROOF study (An RCT to evaluate the use of frozen section technology to improve oncological and functional outcomes in robotic radical prostatectomy)

      Background: Radical prostatectomy is an effective cure for organ confined prostate cancer. Men undergoing radical prostatectomy suffer side effects of incontinence (temporary) and impotence (permanent). Nerve sparing minimises these side effects. However, in the presence of extraprostatic extension, for which there is no reliable preoperative test, nerve sparing can cause positive surgical margin (PSM), necessitating adjuvant radiotherapy which compounds side effects. The NeuroSAFE method uses intraoperative frozen section to check that nerve sparing has not caused a PSM, allowing the nerve to be resected if there is a PSM.
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