Background: Radical prostatectomy is an effective cure for organ confined prostate cancer. Men
undergoing radical prostatectomy suffer side effects of incontinence (temporary) and
impotence (permanent). Nerve sparing minimises these side effects. However, in the
presence of extraprostatic extension, for which there is no reliable preoperative
test, nerve sparing can cause positive surgical margin (PSM), necessitating adjuvant
radiotherapy which compounds side effects. The NeuroSAFE method uses intraoperative
frozen section to check that nerve sparing has not caused a PSM, allowing the nerve
to be resected if there is a PSM.
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© 2017 Published by Elsevier Inc.
