Microsatellite instability (MSI) is one of the new groups of molecular divisions of gastric cancer (GC). The aim of this study was to investigate the pattern of lymph node metastasis according to MSI status.
MSI analysis of 361 GC patients with information about lymph node stations was performed using 5 quasimonomorphic mononucleotide repeats. The metastasis rates for each lymphatic station was analyzed, combined with clinicopathologic characteristics. Stations were divided into compartments 1–3 on the basis of Japanese Classification. A median number (interquartile range, IQR) of 33 (18–50) lymph nodes were removed and analyzed.
N0 status was observed in 53.7% MSI patients, and in 29.7% microsatellite stable (MSS) (p < 0.001).The median value of involved nodes was 1 in MSI vs. 5 in MSS (p < 0.001). Furthermore, the number of involved node stations was significantly lower in the MSI group (p < 0.001). MSS tumors showed a higher propensity to spread to second and third compartment nodes. In absence of lymphovascular invasion only 3.2% cases demonstrated positive nodes beyond the first compartment. Skip metastases were seen in 6.1% MSS patients and 0% MSI (p = 0.011). No difference in the 10-year cancer related survival among MSI and MSS patients was found, for both those with 1st compartment (p = 0.223) and with 2nd compartment involvement (p = 0.814).
MSI GC shows a high rate of N0 stage, a lower number of lymph node metastases, and a less extensive spread to lymph node stations than MSS tumors. These data indicate that tailored lymphadenectomy may be investigated for these patients.
Abbreviations:MSI (Microsatellite instability), GC (gastric cancer), MSS (microsatellite stable), OS (overall survival), UICC/AJCC (International Union Against Cancer/American Joint Cancer Committee), TNM (tumor node metastasis classification), mLNs (metastatic lymph nodes), PCR (polymerase chain reaction), MSI-L (microsatellite instability with low instability), MSI-H (microsatellite instability with high instability), JGCA (Japanese Gastric Cancer Association), JCOG (Japan Clinical Oncology Group), hMLH1 (human homologue of MLH mismatch repair gene), EGFR (epithelial growth factor receptor), HER-2 (human epidermal growth factor receptor 2), IHC (immunohistochemistry), ITCs (isolated tumor cells)
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Published online: September 13, 2017
Accepted: September 1, 2017
© 2017 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.