Abstract
Whether the second generation of parent/offspring type familial nonmedullary thyroid
carcinoma (FNMTC) is more aggressive and has worse prognosis than their first generation
counterpart is controversial. To evaluate the clinicopathologic features and prognosis
of the second generation via a comparison between the two groups, We searched three
databases (PubMed, EMBASE and the Cochrane library) to review studies published before
November 25, 2016. All original studies comparing the clinicopathologic features and
prognosis in the first generation of parent/offspring type FNMTC with its second generation
counterpart were included. The Q-test and I2 test were used to evaluate homogeneity and funnel plot with Egger's test was used
to evaluate publication bias. 6 studies, including 424 subjects were included. There
was significant difference between the first and second generation of parent/offspring
type FNMTC in the age of onset (SMD = −1.20, 95% CI: −2.38, −0.03, p = 0.045), gender
distribution (OR = 0.48, 95% CI: 0.25, 0.90, p = 0.022) and lymph node metastasis
(OR = 1.84, 95%CI: 1.16, 2.92, p = 0.01), while no significant difference in other
variables. Thus we conclude that the second generation of parent/offspring type FNMTC
patients is in higher risk than their first generation counterpart. We believe continuous
study is needed to confirm the result.
Keywords
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Article info
Publication history
Published online: September 12, 2017
Accepted:
September 5,
2017
Identification
Copyright
© 2017 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
