Abstract
Background
Improved preoperative immunonutrition has been shown to decrease the length of stay
(LOS) and complications among patients undergoing elective gastrointestinal cancer
surgeries. The purpose of this study was to determine whether preoperative immunonutrition
supplementation decreases postoperative LOS, infectious complications, and morbidity
in patients undergoing irreversible electroporation (IRE) surgery for locally advanced
pancreatic cancer (LAPC).
Methods
At a regional hepatopancreatobiliary referral center within an academic medical center
71 patients receiving IRE treatment of LAPC were included in the study. The participants
were divided into those receiving preoperative immunonutrition (n = 44) and those
receiving no supplemental preoperative immunonutrition (n = 27). Main outcomes and
measures were LOS, postoperative complications, nutritional risk index (NRI), and
albumin levels.
Results
Patients in both groups were similar for preoperative nutrition parameters and operative
therapy. Patients in the immunonutrition group experienced a statistically significant
decrease in postoperative complications (p = 0.05) and LOS (10.7 vs. 17.4, p = 0.01),
and less of a decrease in nutritional risk index (−12.6 vs. −16.2, p = 0.03) and albumin
levels (−1.1 vs. −1.5, p < 0.01).
Conclusion
Preoperative immunonutrition was clinically significant in decreasing postoperative
complications, LOS, and improving post-surgery NRI and albumin levels in patients
receiving elective IRE treatment of non-resectable pancreatic cancer. These results
indicate that preoperative immunonutrition is effective and feasible in this subset
of cancer patients.
Keywords
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Article info
Publication history
Published online: January 19, 2017
Accepted:
January 4,
2017
Identification
Copyright
© 2017 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
