The concept of precision surgery involves much more than a mastery of technical maneuvers.
The definition of such precision is more sophisticated and involves a deeper understanding
of the underlying biological foundation of disease that is then challenged with targeted,
strategic interventions. Rather than treating many to benefit a few, precision surgery
aims to apply surgical therapy to those most likely to benefit and to avoid surgery
in those doomed to fail. In the realm of surgical oncology, the concept of precision
may be decades old. Dr. Blake Cady, in his 1996 Presidential Address to the New England
Surgical Society, summarized this concept well by stating that ‘the art of surgical
oncology is to apply basic principles flexibly to the individual patient.’
1
Herein, previous efforts exemplifying precision medicine will be reviewed, followed
by a series of advancements that are demonstrative of the promise of precision in
surgical oncology.Keywords
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References
- Basic principles in surgical oncology.Arch Surg. 1997; 132: 338-346
- Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.N Engl J Med. 2001; 344: 783-792
- A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer.N Engl J Med. 2004; 351: 2817-2826
- EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer.J Clin Oncol. 2008; 26: 2311-2319
- Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer.N Engl J Med. 2004; 351: 337-345
- Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: pooled analysis of the CRYSTAL and OPUS randomised clinical trials.Eur J Cancer. 2012; 48: 1466-1475
- Preoperative diagnosis of benign thyroid nodules with indeterminate cytology.N Engl J Med. 2012; 367: 705-715
- Jaundice predicts advanced disease and early mortality in patients with gallbladder cancer.Ann Surg Oncol. 2004; 11: 310-315
- A validated prognostic multigene expression assay for overall survival in resected colorectal cancer liver metastases.Clin Cancer Res. 2016; 22: 2575-2582
- Can KRAS and BRAF mutations limit the benefit of liver resection in metastatic colorectal cancer patients? A systematic review and meta-analysis.Crit Rev Oncol Hematol. 2016; 99: 150-157
Article info
Publication history
Published online: December 13, 2016
Accepted:
November 14,
2016
Identification
Copyright
© 2016 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.