Abstract
Background
Totally implantable venous access port systems are widely used in oncology, with frequent
complications that sometimes necessitate device removal. The aim of this study is
to investigate the impact of the time interval between port placement and initiation
of chemotherapy and the neutropenia-inducing potential of the chemotherapy administered
upon complication-related port removal.
Patients and methods
Between January 2010 and December 2013, 4045 consecutive patients were included in
this observational, single-center prospective study. The chemotherapy regimens were
classified as having a low (<10%), intermediate (10–20%), or high (>20%) risk for
inducing neutropenia.
Results
The overall removal rate due to complications was 7.2%. Among them, port-related infection
(2.5%) and port expulsion (1%) were the most frequent. The interval between port insertion
and its first use was shown to be a predictive factor for complication-related removal
rates. A cut-off of 6 days was statistically significant (p = 0.008), as the removal rate for complications was 9.4% when this interval was 0–5
days and 5.7% when it was ≥6 days. Another factor associated with port complication
rate was the neutropenia-inducing potential of the chemotherapy regimens used, with
removal for complications involved in 5.5% of low-risk regimens versus 9.4% for the
intermediate- and high-risk regimens (p = 0.003).
Conclusion
An interval of 6 days between placement and first use of the port reduces the removal
rate from complications. The intermediate- and high-risk for neutropenia chemotherapy
regimens are related to higher port removal rates from complications than low-risk
regimens.
Keywords
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Article info
Publication history
Published online: November 04, 2016
Accepted:
October 21,
2016
Identification
Copyright
© 2016 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
