Abstract
Introduction
Patients with clinical T4 (cT4) bladder cancer (BCa) infrequently undergo radical
cystectomy (RC). We investigated the reliability of preoperative clinical staging,
perioperative and survival outcomes in patients treated with RC due to cT4a-b BCa
disease at a single tertiary care institution.
Methods
The study relied on 917 BCa patients treated with RC and pelvic lymph node dissection
(PLND) at a single institution between January 1995 and December 2012. We compared
the accuracy of the clinical assessment with final pathology results. Moreover, we
evaluated perioperative outcomes, complication rates and survival after surgery.
Results
The median follow-up was 62 months. Overall, 74 (8.1%) patients presented cT4 stage
at preoperative evaluation. Conversely, a pathological T4 disease was confirmed only
in 68.9% patients staged initially as cT4. No differences were recorded in complications,
30 days readmission or 30 days death rates between cT1–T3 vs. cT4a vs. cT4b (p > 0.1).
At multivariable Cox regression analyses predicting cancer specific mortality, clinical
T4 stage vs. clinical T1–2, clinical T3 stage vs. clinical T1–2 and age were predictors
of worst survival after RC (all p < 0.04).
Conclusions
We recorded poor concordance between preoperative imaging and pathology in cT4 patients.
No differences in major perioperative outcomes and acceptable survival expectancies
were reported in patients treated for cT4 disease.
Keywords
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Article info
Publication history
Published online: September 28, 2016
Accepted:
August 25,
2016
Identification
Copyright
© 2016 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
