Abstract
Background
Intra-nodal naevi (INN) identified during assessment of a sentinel lymph node for
melanoma are not an uncommon finding. Little is known about their clinical significance.
Patients with INN are treated as sentinel node biopsy (SNB) negative currently. Our
aim was to assess the significance of INN in patients who undergo SNB for melanoma.
Methods
353 melanoma patients who underwent a SNB between November 1999 and June 2012 were
retrospectively analysed from a prospectively collected database. The patients were
divided into SNB negative, INN, isolated tumour cells (ITC) and SNB positive groups.
Outcome measures of nodal recurrence, distal recurrence and survival were used to
assess the differences between the groups.
Results
203 patients were SNB negative, 103 were positive of which 13 had ITC, 47 had INN
(13%). Overall median follow up was 2.3 years (range 0.1–14.1 years). Our data demonstrated
a statistically significant survival benefit for patients who had an INN compared
to the SNB positive and ITC group. INN patients also had significantly better nodal
and regional recurrence compared to SNB positive patients. There was no difference
between INN and SNB negative patients.
Conclusion
We have clinically demonstrated that patients with INN on SNB can be adequately treated
as SNB negative patients.
Keywords
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Article info
Publication history
Published online: May 19, 2016
Accepted:
April 8,
2016
Identification
Copyright
© 2016 Elsevier Ltd. All rights reserved.
