Abstract
Objective
To compare perioperative and clinico-pathological outcomes of patients with early-stage
cervical cancer who underwent robot-assisted radical hysterectomy (RRH) and open radical
hysterectomy (ORH).
Methods
This retrospective multi-center study abstracted demographic, clinico-pathological
and perioperative outcomes data from medical records of 491 cervical cancer patients
treated with RRH (n = 259) ORH (n = 232) between 2005 and 2011 at two American and
one Norwegian University Cancer Centres.
Results
Mean estimated blood loss (EBL) and transfusion rates were less for RRH than for ORH
(97 vs. 49 mL, p < 0.001, and 3% vs. 7%, p = 0.018, respectively). Mean length of hospital stay (LOS) was significantly shorter
in RRH versus ORH (1.8 vs. 5.1 days, p < 0.001). Mean operative time was longer for RRH than ORH (220 vs. 156 min, p < 0.001). Although overall complications were similar (p = 0.49), intra-operative complications were less common in the RRH group than ORH
(4% vs. 10%, p = 0.004). In multivariate regression analyses longer operative time, less EBL and
intra-operative complications, shorter LOS, and more pre-operative cone were significantly
associated with RRH versus ORH. Recurrence and death rates were not statistically
different for the two groups at a mean follow-up time of 39 months (p = 1.00 and p = 0.48, respectively).
Conclusions
RRH had improved clinical outcomes compared to ORH in the treatment of early-stage
cervical cancer in terms of EBL, intra-operative complications, transfusion rates,
LOS, and pre-operative cone. Disease recurrence and survival were comparable for the
two procedures.
Keywords
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Article info
Publication history
Published online: January 20, 2016
Accepted:
December 1,
2015
Footnotes
☆Previous presentation: Parts of this study were presented at a Scientific Plenary Session of the 46th Annual Meeting on Women's Cancer, Society of Gynecologic Oncology (SGO), in Chicago, IL, March 2015.
Identification
Copyright
© 2016 Elsevier Ltd. Published by Elsevier Inc. All rights reserved.
