Advertisement
Research Article| Volume 35, ISSUE 5, P481-485, May 2009

Download started.

Ok

Surgical treatment of gastric cancer in Latvia: Results of centralized experience

      Abstract

      Background

      Although the mortality for gastric cancer is decreasing in Western Europe and United States, it still remains high in Eastern Europe. This study was aimed at evaluating short- and long-term results of surgical treatment of gastric cancer performed in Latvia Oncology Center.

      Methods

      Retrospectively collected data from 461 patients who underwent gastrectomy with curative intent in Latvia Oncology Center from January 2001 to December 2005 were analyzed statistically.

      Results

      An average (range) of 92.2 (81–102) R0–R1 gastrectomies was performed each year. Post-operative complications occurred in 75 patients (16.3%); in-hospital mortality was 3.3%. The overall 5-year survival was 50.8%. In 444 cases (96.3%) there was histopathologic confirmation of R0-resection with a 5-year survival of 52.5% (P<0.001). Considering pT category, 5-year survival was 88.6% for pT1 patients, 65% for pT2, 42.3% for pT3 and 27% for pT4 (P<0.001). Considering pN category, 5-year survival was 67% for pN0 patients, 30% for pN1 and 29% for pN2-3 (P<0.001).

      Conclusions

      Clinico-pathologic characteristics of patients who underwent resection with curative intent are comparable to other Western experiences. Short- as well as long-term results are also similar if not for pN+ patients where no difference between pN1 and pN2 cases was observed.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to European Journal of Surgical Oncology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Devessa S.S.
        • Blot W.J.
        • Fraumeni Jr., J.F.
        Changing patterns in the incidence of esophageal and gastric carcinoma in the United States.
        Cancer. 1998; 83: 2049-2053
        • Ferlay J.
        • Autier P.
        • Boniol M.
        • Heanue M.
        • Colombet M.
        • Boyle P.
        Estimates of the cancer incidence and mortality in Europe in 2006.
        Ann Oncol. 2007; 18: 581-592
        • American Joint Committee on Cancer
        AJCC cancer staging atlas.
        Springer Science+Business Media Inc, New York2006
        • Marubini E.
        • Valsecchi M.G.
        Analysis survival data from clinical trial and observational study.
        John Wiley & Sons, Chichester1995
        • Clark C.
        • Thirlby R.
        • Picozzi V.
        • Schembre Jr., D.
        • Cummings F.
        • Lin E.
        Current problems in surgery: gastric cancer.
        Curr Probl Surg. 2006; 43: 566-670
        • Songun I.
        • Bonenkamp J.J.
        • Hermans J.
        • van Krieken J.H.
        • van de Velde C.J.
        Prognostic value of resection-line involvement in patients undergoing curative resections for gastric cancer.
        Eur J Cancer. 1996; 32A: 433-437
        • Sano T.
        • Mudan S.S.
        No advantage of reoperation for positive resection margins in node positive gastric cancer patients?.
        Jpn J Clin Oncol. 1999; 29: 283-284
        • Fujimoto S.
        • Takahashi M.
        • Mutou T.
        • Kobayashi K.
        • Toyosawa T.
        • Ohkubo H.
        Clinicopathologic characteristics of gastric cancer patients with cancer infiltration at surgical margin at gastrectomy.
        Anticancer Res. 1997; 17: 689-694
        • Nanthakumaran S.
        • Fernandes E.
        • Thompson A.M.
        • Rapson T.
        • Gilbert F.J.
        • Park K.G.
        Morbidity and mortality rates following gastric cancer surgery and contiguous organ removal, a population based study.
        Eur J Surg Oncol. 2005; 31: 1141-1144
        • Kunisaki C.
        • Akiyama H.
        • Nomura M.
        • et al.
        Surgical outcomes in patients with T4 gastric carcinoma.
        J Am Coll Surg. 2006; 202: 223-230
        • Harrison L.E.
        • Karpeh M.S.
        • Brennan M.F.
        Extended lymphadenectomy is associated with a survival benefit for node-negative gastric cancer.
        J Gastrointest Surg. 1998; 2: 126-131
        • Roviello F.
        • Marrelli D.
        • Morgagni P.
        • et al.
        Italian research group for gastric cancer. Survival benefit of extended D2 lymphadenectomy in gastric cancer with involvement of second level lymph nodes: a longitudinal multicenter study.
        Ann Surg Oncol. 2002; 9: 894-900
        • Di Leo A.
        • Marrelli D.
        • Roviello F.
        • et al.
        Lymph nodes involvement in gastric cancer for different tumor's site and T stage. Italian research group for gastric cancer (IRGGC) experience.
        J Gastrointest Surg. 2007; 11: 1146-1153
        • Edwards P.
        • Blackshaw G.R.
        • Lewis W.G.
        • Barry J.D.
        • Allison M.C.
        • Jones D.R.
        Prospective comparison of D1 vs modified D2 gastrectomy for carcinoma.
        Br J Cancer. 2004; 90: 1888-1892
        • Enzinger P.C.
        • Benedetti J.K.
        • Meyerhardt J.A.
        • et al.
        Impact of hospital volume on recurrence and survival after surgery for gastric cancer.
        Ann Surg. 2007; 245: 426-434
        • Siewert J.R.
        • Bottcher K.
        • Roder J.D.
        • Busch R.
        • Hermanek P.
        • Meyer H.J.
        Prognostic relevance of systematic lymph node dissection in gastric carcinoma.
        Br J Surg. 1993; 80: 1015-1018
        • Maeta M.
        • Yamashiro H.
        • Saito H.
        • et al.
        A prospective pilot study of extended (D3) and superextended para-aortic lymphadenectomy (D4) in patients with T3 or T4 gastric cancer managed by total gastrectomy.
        Surgery. 1999; 125: 325-331
        • Sasako M.
        • Sano T.
        • Yamamoto S.
        • et al.
        Japan Clinical Oncology Group (JCOG). D2 lymphadenectomy alone or with para-aortic nodal dissection for gastric cancer.
        N Engl J Med. 2008; 359: 453-462