European Journal of Surgical Oncology
Volume 36, Issue 8 , Pages 737-744 , August 2010

Intra-operative evaluation of the sentinel lymph node for T1-N0 breast-cancer patients: Always or never? A risk/benefit and cost/benefit analysis

  • G. Canavese

      Affiliations

    • Advanced Surgical Senology Unit, National Cancer Research Institute, Genoa, Italy
    • ,
  • P. Bruzzi

      Affiliations

    • Clinical Epidemiology Unit, National Cancer Research Institute, Italy
    • ,
  • A. Catturich

      Affiliations

    • Advanced Surgical Senology Unit, National Cancer Research Institute, Genoa, Italy
    • ,
  • C. Vecchio

      Affiliations

    • Advanced Surgical Senology Unit, National Cancer Research Institute, Genoa, Italy
    • ,
  • D. Tomei

      Affiliations

    • Advanced Surgical Senology Unit, National Cancer Research Institute, Genoa, Italy
    • ,
  • F. Carli

      Affiliations

    • Anatomy and Cytohistology Unit, National Cancer Research Institute, Genoa, Italy
    • ,
  • M. Truini

      Affiliations

    • Anatomy and Cytohistology Unit, National Cancer Research Institute, Genoa, Italy
    • ,
  • G.B. Andreoli

      Affiliations

    • Institute Medical Direction, National Cancer Research Institute, Genoa, Italy
    • ,
  • V. Priano

      Affiliations

    • Advanced Surgical Senology Unit, National Cancer Research Institute, Genoa, Italy
    • ,
  • B. Dozin

      Affiliations

    • Clinical Epidemiology Unit, National Cancer Research Institute, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 010 5737492; fax: +39 010 354103.

,Accepted 7 June 2010.

References 

  1. Kim T, Giuliano AE, Lyman GH. Lymphatic mapping and sentinel lymph node biopsy in early-stage breast carcinoma: a metaanalysis. Cancer. 2006;106:4–16
  2. Krag DN, Anderson SJ, Julian TB, et al. National surgical adjuvant breast and bowel project. Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial. Lancet Oncol. 2007;8:881–888
  3. Mansel RE, Fallowfield L, Kissin M, et al. Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer: the ALMANAC trial. J Natl Cancer Inst. 2006;98:599–609
  4. Veronesi U, Paganelli G, Galimberti V, et al. Sentinel-node biopsy to avoid axillary dissection in breast cancer with clinically negative lymph-nodes. Lancet. 1997;349:1864–1867
  5. Giuliano AE, Jones RC, Brennan M, Statman R. Sentinel lymphadenectomy in breast cancer. J Clin Oncol. 1997;15:2345–2350
  6. Krag D, Weaver D, Ashikaga T, et al. The sentinel node in breast cancer-a multicenter validation study. N Engl J Med. 1998;339:941–946
  7. Schwartz GF, Giuliano AE, Veronesi U Consensus Conference Committee. Proceedings of the consensus conference on the role of sentinel lymph node biopsy in carcinoma of the breast, April 19–22, 2001, Philadelphia, Pennsylvania. Cancer. 2002;94:2542–2551
  8. Lyman GH, Giuliano AE, Somerfield MR, et al. American Society of clinical Oncology American society of clinical oncology guideline recommendations for sentinel lymph node biopsy in early-stage breast cancer. J Clin Oncol. 2005;23:7703–7720
  9. Silverstein MJ, Lagios MD, Recht A, et al. Image-detected breast cancer: state of the art diagnosis and treatment. J Am Coll Surg. 2005;201:586–597
  10. Weiser MR, Montgomery LL, Susnik B, Tan LK, Borgen PI, Cody HS. Is routine intraoperative frozen-section examination of sentinel lymph nodes in breast cancer worthwhile?. Ann Surg Oncol. 2000;7:651–655
  11. Chan SW, LaVigne KA, Port ER, et al. Does the benefit of sentinel node frozen section vary between patients with invasive duct, invasive lobular, and favorable histologic subtypes of breast cancer?. Ann Surg. 2008;247:143–149
  12. Canavese G, Catturich A, Vecchio C, et al. Sentinel node biopsy compared with complete axillary dissection for staging early breast cancer with clinically negative lymph nodes: results of randomized trial. Ann Oncol. 2009;20:1001–1007

PII: S0748-7983(10)00186-1

doi: 10.1016/j.ejso.2010.06.010

European Journal of Surgical Oncology
Volume 36, Issue 8 , Pages 737-744 , August 2010

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