European Journal of Surgical Oncology
Volume 36, Issue 8 , Pages 709-717 , August 2010

Gastric cancer in the elderly: An overview

  • M.W. Saif

      Affiliations

    • Department of Clinical Oncology, Yale University School of Medicine New Haven, CT, USA
    • ,
  • N. Makrilia

      Affiliations

    • Oncology Unit, 3rd Dept of Medicine, Athens University School of Medicine, Building Z, Sotiria General Hospital, Mesogion 152, 115 27 Athens, Greece
    • ,
  • A. Zalonis

      Affiliations

    • Oncology Unit, 3rd Dept of Medicine, Athens University School of Medicine, Building Z, Sotiria General Hospital, Mesogion 152, 115 27 Athens, Greece
    • ,
  • M. Merikas

      Affiliations

    • Oncology Unit, 3rd Dept of Medicine, Athens University School of Medicine, Building Z, Sotiria General Hospital, Mesogion 152, 115 27 Athens, Greece
    • ,
  • K. Syrigos

      Affiliations

    • Oncology Unit, 3rd Dept of Medicine, Athens University School of Medicine, Building Z, Sotiria General Hospital, Mesogion 152, 115 27 Athens, Greece
    • Corresponding Author InformationCorresponding author. Tel.: +30 210 7475 034; fax: +30 210 7781 035.

,Accepted 17 May 2010.

References 

  1. Saito H, Osaki T, Murakami D, et al. Effect of age on prognosis in patients with gastric cancer. ANZ J Surg. 2006;76:458–461
  2. Medina-Franco H, Heslin MJ, Cortes-Gonzalez R. Clinicopathological characteristics of gastric carcinoma in young and elderly patients: a comparative study. Ann Surg Oncol. 2000;7:515–519
  3. Kunisaki C, Akiyama H, Nomura M, et al. Clinicopatological features of gastric carcinoma in younger and middle-aged patients: a comparative study. J Gastrointest Surg. 2006;10:1023–1032
  4. Tokunaga A, Nishi K, Matsukura N, et al. Estrogen and progesterone receptors in gastric cancer. Cancer. 1986;57:1376–1379
  5. Harrison JD, Ja Jones, Ellis IO, Morris DL. Oestrogen receptor D5 antibody is an independent negative prognostic factor in gastric cancer. Br J Surg. 1991;78:334–336
  6. Kurita H. Clinico-epidemiological study of stomach cancer considering sex and age differences. Jpn J Cancer Clin. 1974;20:580–593
  7. Furukawa H, Iwanaga T, Koyama H, Taniguchi H. Effects of sex hormones on carcinogenesis in the stomach of rats. Cancer Res. 1982;42:5181–5182
  8. Furukawa H, Iwanaga T, Hiratsuka M, et al. Gastric cancer in young adults: growth accelerating effect of pregnancy and delivery. J Surg Oncol. 1994;55:3–6
  9. Maeta M, Yamashiro H, Oka A, Tsujitani S, Ikeguchi M, Kaibara N. Gastric cancer in the young with special reference to 14 pregnancy-associated cases: analysis based on 2325 consecutive cases of gastric cancer. J Surg Oncol. 1995;58:191–195
  10. Santoro R, Carboni F, Lepiane P, Ettorre GM, Santoro E. Clinicopathological features and prognosis of gastric cancer in young European adults. Br J Surg. 2007;94:737–742
  11. Huntsman DG, Carreiro F, Fr Lewis, et al. Early gastric cancer in young, asymptomatic carriers of germ-line E-cadherin mutations. N Engl J Med. 2001;344:1904–1909
  12. Caldas C, Carneiro F, Lynch HT, et al. Familial gastric cancer: overview and guidelines for management. J Med Genet. 1999;36:873–880
  13. Tahara E. Molecular biology of gastric cancer. World J Surg. 1995;19:484–490
  14. Arai T, Esaki Y, Inoshita N, et al. Pathologic characteristics of gastric cancer in the elderly: a retrospective study of 994 surgical patients. Gastric Cancer. 2004;7:154–159
  15. Kim DY, Joo JK, Ryu SY, Park YK, Kim YJ, Kim SK. Clinicopathologic characteristics of gastric carcinoma in elderly patients: a comparison with young patients. World J Gastroenterol. 2005;11(1):22–26
  16. Ishigami S, Natsugoe S, Saihara T, et al. Clinical and pathologic features of early gastric cancer in elderly patients. Hepatogastroenterology. 1997;44(16):1164–1168
  17. Inoshita N, Yanagisawa A, Arai T, Kitagawa T, Hirokawa K, Kato Y. Pathological characteristics of gastric carcinomas in the very old. Jpn J Cancer Res. 1998;89:1087–1092
  18. Japanese Gastric Cancer Association . Japanese classification of gastric carcinoma. 2nd English Ed. Gastric Cancer. 1998;1:10–24
  19. Fujiya T, Endoh K, Mikuni J, et al. Clinicopathological characteristics and surgical outcome of gastric carcinoma with regard to aging. Jpn J Gastroenterol Surg. 1997;30:1699–1705
  20. Kitamura K, Yamaguchi T, Taniguchi H, et al. Clinicopathological characteristics of gastric cancer in the elderly. Br J Cancer. 1996;73(6):798–802
  21. Kunisaki C, Kobayashi S, Kido Y, et al. Clinicopathological evaluation of senile patients with gastric cancer. Jpn J Clin Surg. 1996;57:1831–1837
  22. Sho M, Imagawa A, Hosoi T, et al. Clinical study of surgical cases of gastric cancer in patients over 80 years old. Jpn J Soc Clin Surg. 1996;57:1838–1843
  23. Ming S. Gastric carcinoma. A pathological classification. Cancer. 1977;39:2475–2485
  24. Esaki Y, Hirokawa K, Yamashiro M. Multiple gastric cancers in the aged with special reference to intramucosal cancers. Cancer. 1987;59:560–565
  25. Kitamura K, Yamaguchi T, Okamoto K, et al. Clinicopathologic features of synchronous multifocal early gastric cancers. Anticancer Res. 1997;17(1B):643–646
  26. Mitsudomi T, Watanabe A, Matsusaka T, et al. A clinicopathological study of synchronous multiple gastric cancer. Br J Cancer. 1989;76(3):237–240
  27. Holmes FF, Hearne E. Cancer stage-to-stage relationship: implications for cancer screening in the elderly. J Am Geriatr Soc. 1981;29:55–57
  28. Esaki Y, Hirayama R, Hirokawa K. A comparison of patterns of metastasis in gastric cancer by histologic type and age. Cancer. 1990;65:2086–2090
  29. Wu CW, Lo SS, Shen KH, Hsieh MC, Lui WY, P’eng FK. Surgical mortality, survival and quality of life after resection for gastric cancer in the elderly. World J Surg. 2000;24:465–472
  30. Maehara Y, Emi Y, Tomisaki S, et al. Age-related characteristics of gastric carcinoma in young and elderly patients. Cancer. 1996;77(9):1774–1780
  31. Nielsen J, Aagaard J, Toftgaard C. Gastric cancer with special reference to prognostic factors: a review of 779 cases. Acta Chir Scand. 1985;151:49–55
  32. Goseki N. The relationship between the histological type of gastric carcinoma and the mode of spreading, Stomach Intest. 1983;18:643–649
  33. Okuno K, Shigeoka H, Tanaka A, Hirai N, Matsumura E, Yasutomi M. Clinicopathological evaluation of T2-gastric cancer among age groups. Hepatogastroenterology. 2000;47:1180–1182
  34. Wang JY, Hsieh JS, Huang CJ, Huang YS, Huang TJ. Clinicopathologic study of advanced gastric cancer without serosal invasion in young and old patients. J Surg Oncol. 1996;63(1):36–40
  35. Fujimoto S, Takahashi M, Ohkubo H, et al. Comparative clinicopathologic features of early gastric cancer in young and older patients. Surgery. 1994;115(4):516–520
  36. Cunningham D, Oliveira J ESMO Guidelines Working Group. Gastric cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol. 2008;19(Suppl. 2):ii23–ii24
  37. Winslet MC, Mohsen YMA, Powell J. The influence of age on the surgical management of carcinoma of the stomach. Eur J Surg Oncol. 1996;22:220–224
  38. Damhuis RA, Tilanus HW. The influence of age on resection rates and postoperative mortality in 2773 patients with gastric cancer. Eur J Cancer. 1995;31A:928–931
  39. Coluccia C, Ricci EB, Martzola GG, Molaschi M, Nano MG. Gastric cancer in the elderly: results of surgical treatment. Int Surg. 1987;72:4–10
  40. Roviello F, Marrelli D, De Stefano A, Messano A, Pinto E, Carli A. Complications after surgery for gastric cancer in patients aged 80 years and over. Jpn J Clin Oncol. 1998;28:116–122
  41. Benhamiche AM, Faivre J, Tazi AM, Couillault C, Villing AL, Rat P. Time trends in diagnostic strategy, treatment, and prognosis of gastric cancer in the elderly: a population based study. Eur J Cancer Prev. 1997;6:71–77
  42. Bonenkamp JJ, Songun I, Hermans J, et al. Randomised comparison of morbidity after D1 and D2 dissection for gastric cancer in 996 Dutch patients. Lancet. 1995;345:745–748
  43. Katai H, Sasako M, Sano M, Maruyama K. The outcome of surgical treatment for gastric carcinoma in the elderly. Jpn J Clin Oncol. 1998;28:112–115
  44. Eguchi T, Fujii M, Takayama T. Mortality for gastric cancer in elderly patients. J Surg Oncol. 2003;84:132–136
  45. Kitamura K, Sugimachi K, Saku M. Evaluation of surgical treatment for patients with gastric cancer who are over 80 years of age. Hepatogastroenterology. 1999;46:2074–2080
  46. Hanazaki K, Wakabayashi M, Sodeyama H, et al. Surgery for gastric cancer in patients older than 80 years of age. Hepatogastroenterology. 1998;45:268–275
  47. Coniglio A, Tiberio GA, Busti M, et al. Surgical treatment for gastric carcinoma in the elderly. J Surg Oncol. 2004;88:201–205
  48. Orsenigo E, Tomajer V, Palo SD, et al. Impact of age on postoperative outcomes in 1118 gastric cancer patients undergoing surgical treatment. Gastric Cancer. 2007;10:39–44
  49. Saidi RF, Bell JL, Dudrick PS. Surgical resection for gastric cancer in elderly patients: is there a difference in outcome?. J Surg Res. 2004;118:15–20
  50. Kubota H, Kotoh T, Dhar DK, et al. Gastric resection in the aged (> or =80 years) with gastric carcinoma: a multivariate analysis of prognostic factors. Aust N Z J Surg. 2000;70:254–257
  51. Kunisaki C, Akiyama H, Nomura M, et al. Comparison of surgical outcomes of gastric cancer in elderly and middle-aged patients. Am J Surg. 2006;191(2):216–224
  52. Hara H, Isozaki H, Nomura E, Fujii K, Sako S, Tanigawa N. Evaluation of treatment strategies for gastric cancer in the elderly according to the number of abnormal parameters on preoperative examination. Jpn J Surg. 1999;29:837–841
  53. Sasako M. Risk factors for surgical treatment in the Dutch. Gastric Cancer Trial. Br J Surg. 1997;84:1567–1571
  54. Eguchi T, Takahashi Y, Ikarashi M, Kasahara M, Fujii M. Is extended lymph node dissection necessary for gastric cancer in elderly patients?. Eur J Surg. 2000;166:949–953
  55. MacDonald JS, Smalley SR, Benedetti J, et al. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med. 2001;345:725–730
  56. Cunningham D, Allum WH, Stenning SP, et al. Perioperative chemotherapy versus surgery alone for respectable gastroesophageal cancer. N Engl J Med. 2006;355:11–20
  57. Sakuramoto S, Sasako M, Yamaguchi T, et al. Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine. N Engl J Med. 2007;357(18):1810–1820
  58. Tsuburaya A, Sakamoto J, Morita S, et al. A randomized phase III trial of post-operative adjuvant oral fluoropyrimidine versus sequential paclitaxel/oral fluoropyrimidine; and UFT versus S1 for T3/T4 gastric carcinoma: the Stomach Cancer Adjuvant Multi-institutional Trial Group (Samit) Trial. Jpn J Clin Oncol. 2005;35(11):672–675
  59. Trumper M, Ross PJ, Cunningham D, et al. Efficacy and tolerability of chemotherapy in elderly patients with advanced oesophago-gastric cancer: a pooled analysis of three clinical trials. Eur J Cancer. 2006;42:827–834
  60. Van Cutsem E, Moiseyenko VM, Tjulandin S, et al. Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: a report of the V325 study group. J Clin Oncol. 2006;24:4991–4997
  61. Cunningham D, Starling N, Rao S, et al. Capecitabine and oxaliplatin for advanced esophagogastric cancer. N Engl J Med. 2008;358:36–46
  62. Al-Batran SE, Hartmann JT, Probst S, et al. Phase III trial in metastatic gastroesophageal adenocarcinoma with fluorouracil, leucovorin plus either oxaliplatin or cisplatin: a study of the Arbeitsgemeinschaft Internistische Onkologie. J Clin Oncol. 2008;26:1435–1442
  63. Choi I, Lee K, Oh D, et al. Oxaliplatin, 5-fluorouracil, and folic acid as first-line chemotherapy for elderly patients with advanced gastric cancer. J Clin Oncol. 2006;24(18S):14155
  64. Liu ZF, Guo QS, Zhang XQ, et al. Biweekly oxaliplatin in combination with continuous infusional 5-fluorouracil and leucovorin (modified FOLFOX-4 regimen) as first-line chemotherapy for elderly patients with advanced gastric cancer. Am J Clin Oncol. 2008;31:259–263
  65. Koizumi W, Nahara H, Hara T, et al. S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial. Lancet Oncol. 2008;9:215–221
  66. Seol YM, Song MK, Choi YJ, et al. Oral fluoropyrimidines (Capecitabine or S-1) and cisplatin as first line treatment in elderly patients with advanced gastric cancer: a retrospective study. Jpn J Clin Oncol. 2009;39:43–48
  67. Kang Y, Lee J, Min Y. A randomized multi-center phase II trial of capecitabine (X) versus S-1 (S) as first-line treatment in elderly patients with metastatic or recurrent unresectable gastric cancer. J Clin Oncol. 2007;25:18S;[Abstract 4546]
  68. Ilson DH. Docetaxel, cisplatin, and fluorouracil in gastric cancer: does the punishment fit the crime?. J Clin Oncol. 2007;25:3188–3190

PII: S0748-7983(10)00131-9

doi: 10.1016/j.ejso.2010.05.023

European Journal of Surgical Oncology
Volume 36, Issue 8 , Pages 709-717 , August 2010

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