Risk of invasive breast cancer after lobular intra-epithelial neoplasia: Review of the literature

Ansquer, Y.; Delaney, S.; Santulli, P.; Salomon, L.; Carbonne, B.; Salmon, R.

doi:10.1016/j.ejso.2010.05.019

« Previous Next »European Journal of Surgical Oncology
Volume 36, Issue 7 , Pages 604-609, July 2010

Risk of invasive breast cancer after lobular intra-epithelial neoplasia: Review of the literature

Y. Ansquer
- Hôpital St Antoine, Assistance Publique Hôpitaux de Paris, Université Pierre et Marie Curie, Paris VI, Service de Gynécologie Obstétrique, 184 rue du Faubourg St Antoine, 75012 Paris, Cedex 12, France
- Corresponding author. Tel.: +33 1 49 28 27 22; fax: +33 1 49 28 29 74.
S. Delaney
- Hôpital St Antoine, Assistance Publique Hôpitaux de Paris, Université Pierre et Marie Curie, Paris VI, Service de Gynécologie Obstétrique, 184 rue du Faubourg St Antoine, 75012 Paris, Cedex 12, France
P. Santulli
- Hôpital St Antoine, Assistance Publique Hôpitaux de Paris, Université Pierre et Marie Curie, Paris VI, Service de Gynécologie Obstétrique, 184 rue du Faubourg St Antoine, 75012 Paris, Cedex 12, France
L. Salomon
- Hôpital Louis Mourier, Assistance Publique Hôpitaux de Paris, Université Paris VII, département de Santé Publique, 178 rue des Renouillers, 92 701 Colombes Cedex, France
B. Carbonne
- Hôpital St Antoine, Assistance Publique Hôpitaux de Paris, Université Pierre et Marie Curie, Paris VI, Service de Gynécologie Obstétrique, 184 rue du Faubourg St Antoine, 75012 Paris, Cedex 12, France
R. Salmon
- Institut Curie, Département de chirurgie, 26 rue d'’Ulm, 75005 Paris, France

Accepted 17 May 2010.

Abstract

Objective

Lobular intra-epithelial neoplasia (LIN) is a rare breast disease that has been regarded alternately as a risk factor for invasive breast cancer in both breasts or a true breast cancer precursor. The controversy is largely dependent on the estimation of the IBC (Invasive Breast Cancer) risk after LIN; however a systematic review of the published data has not been previously performed. We aimed to review the IBC after LIN and the characteristics of those cancers.

Methods

A PubMed search was performed to identify the published articles in English addressing the breast cancer risk after LIN.

Results

There was a wide range in the figures estimating the risk of the breast cancer among the 22 studies that form the basis of this review. The cumulative average risk of invasive breast cancer (IBC) was 8.7% (range 0–33). It was 4.7% (range 0–25) for the ipsilateral and 4.2% (range 0–16) for the contralateral breast. 52% of the breast cancers occurred more than 10 years after the initial LIN. A lobular histotype was present in 30% (range 0–67%) of all IBC.

Conclusions

LIN should be considered both as a risk factor (low and similar level of IBC risk for both breasts, long delay between LIN and IBC) and a precursor for IBC (over-representation of lobular histotype).

Keywords: Lobular intra-epithelial neoplasia, Lobular carcinoma in situ, Atypical lobular hyperplasia, Breast cancer, Review