European Journal of Surgical Oncology
Volume 36, Issue 7 , Pages 632-638 , July 2010

Separate cavity margins excision as a complement to conservative breast cancer surgery

  • G. Zavagno

      Affiliations

    • Clinica Chirurgica II – Breast Unit, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 049 8212071; fax: +39 049 651891.
    • ,
  • M. Donà

      Affiliations

    • Clinica Chirurgica II – Breast Unit, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
    • ,
  • E. Orvieto

      Affiliations

    • Anatomia Patologica, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
    • ,
  • S. Mocellin

      Affiliations

    • Clinica Chirurgica II – Breast Unit, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
    • ,
  • S. Pasquali

      Affiliations

    • Clinica Chirurgica II – Breast Unit, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
    • ,
  • E. Goldin

      Affiliations

    • Clinica Chirurgica II – Breast Unit, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
    • ,
  • M. Lo Mele

      Affiliations

    • Anatomia Patologica, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
    • ,
  • V. Belardinelli

      Affiliations

    • Clinica Chirurgica II – Breast Unit, University of Padova, Via Giustiniani 2, 35128 Padova, Italy
    • ,
  • D. Nitti

      Affiliations

    • Clinica Chirurgica II – Breast Unit, University of Padova, Via Giustiniani 2, 35128 Padova, Italy

,Accepted 17 May 2010.

References 

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  2. Veronesi U, Cascinelli N, Mariani L, et al. Twenty year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med. 2002;347:1227–1232
  3. Schnitt SJ. Risk factors for local recurrence in patients with invasive breast cancer and negative surgical margins of excision: where are we and where are we going?. Am J Clin Pathol. 2003;120:485–488
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  5. Cellini C, Hollembeck ST, Cristos P, et al. Factors associated with residual breast cancer after re-excision for close or positive margins. Ann Surg Oncol. 2004;11:915–920
  6. Scopa CD, Aroukatos P, Tsamandas AC, Aletra C. Evaluation of margin status in lumpectomy specimens and residual breast carcinoma. Breast J. 2006;12:150–153
  7. Dillon MF, Hill ADK, Quinn CM, McDermott EW, O’Higgins NO. A pathologic assessment of adequate margin status in breast-conserving therapy. Ann Surg Oncol. 2006;13:333–339
  8. Zavagno G, Goldin E, Mencarelli R, et al. Role of resection margins in patients treated with breast conservation surgery. Cancer. 2008;112:1923–1931
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  12. Keskek M, Kothari M, Ardehali B, Betambeau N, Nasiri N, Gui GPH. Factors predisposing to cavity margin positivity following conservation surgery for breast cancer. Eur J Surg Oncol. 2004;30:1058–1064
  13. Huston TL, Pigalarga R, Osborne MP, Tousimis E. The influence of additional surgical margins on the total specimen volume excised and the reoperative rate after breast-conserving surgery. Am J Surg. 2006;192:509–512
  14. Marudanayagam R, Singhal R, Tanchel B, O’Connor B, Balasubramanian B, Paterson I. Effect of cavity shaving on reoperation rate following breast-conserving surgery. Breast J. 2008;14:570–573
  15. Jacobson AF, Asad J, Boolbol SK, Osborne MP, Boachie-Adjej K, Feldman SM. Do additional shaved margins at the time of lumpectomy eliminate the need for re-excision?. Am J Surg. 2006;196:556–558
  16. Tengher-Barna I, Hequet D, Reboul-Marty J, et al. Prevalence and predictive factors for the detection of carcinoma in cavity margin performed at the time of breast lumpectomy. Mod Pathol. 2009;22:299–305
  17. Rizzo M, Iyengar R, Gabram SGA, et al. The effects of additional tumor cavity sampling at the time of breast-conserving surgery on final margin status, volume of resection and pathologist workload. Ann Surg Oncol. 2009;Epub ahead of print
  18. Holland R, Velig SH, Mravunac M, Hendriks JH. Histologic multifocality of Tis, T1-T2 breast carcinomas. Implications for clinical trials of breast-conserving surgery. Cancer. 1985;56:979–990
  19. Vaida JS, Vijas JJ, Chinoy RF, Merchant M, Sharma OP, Mittra I. Multicentricity of breast cancer: whole organ analysis and clinical implications. Br J Cancer. 1996;74:820–824
  20. Hewes JC, Imkampe A, Haji A, Bates T. Importance of routine cavity sampling in breast conservation surgery. Br J Surg. 2009;96:47–53
  21. Peterson ME, Schultz DJ, Reynolds C, Solin LJ. Outcomes in breast cancer patients relative to margin status after treatment with breast-conserving surgery and radiation therapy: the University of Pennsylvania experience. Int J Radiat Oncol Biol Phys. 1999;43:1029–1035
  22. Park CC, Mitsumori M, Nixon A, et al. Outcome at 8 years after breast-conserving surgery and radiation therapy for invasive breast cancer: influence of margin status and systemic therapy on local recurrence. J Clin Oncol. 2000;18:1668–1675

PII: S0748-7983(10)00126-5

doi: 10.1016/j.ejso.2010.05.018

European Journal of Surgical Oncology
Volume 36, Issue 7 , Pages 632-638 , July 2010

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