Impact of tumor infiltration pattern into the surrounding tissue on prognosis of the subserosal gastric cancer (pT2b)

Song, K.Y.; Hur, H.; Jung, C.K.; Jung, E.S.; Kim, S.N.; Jeon, H.M.; Park, C.H.

doi:10.1016/j.ejso.2010.04.006

« Previous Next »European Journal of Surgical Oncology
Volume 36, Issue 6 , Pages 563-567, June 2010

Impact of tumor infiltration pattern into the surrounding tissue on prognosis of the subserosal gastric cancer (pT2b)

K.Y. Song
- Department of Surgery, Division of Gastrointestinal Surgery, The Catholic University of Korea, College of Medicine, Seoul, Seoul St. Mary’s Hospital. 505 Banpo-dong, Seocho-gu, Seoul 137-701 Republic of Korea
H. Hur
- Department of Surgery, Division of Gastrointestinal Surgery, The Catholic University of Korea, College of Medicine, Seoul, Seoul St. Mary’s Hospital. 505 Banpo-dong, Seocho-gu, Seoul 137-701 Republic of Korea
C.K. Jung
- Department of Hospital Pathology, The Catholic University of Korea, College of Medicine, Seoul, Republic of Korea
E.S. Jung
- Department of Hospital Pathology, The Catholic University of Korea, College of Medicine, Seoul, Republic of Korea
S.N. Kim
- Department of Surgery, Division of Gastrointestinal Surgery, The Catholic University of Korea, College of Medicine, Seoul, Seoul St. Mary’s Hospital. 505 Banpo-dong, Seocho-gu, Seoul 137-701 Republic of Korea
H.M. Jeon
- Department of Surgery, Division of Gastrointestinal Surgery, The Catholic University of Korea, College of Medicine, Seoul, Seoul St. Mary’s Hospital. 505 Banpo-dong, Seocho-gu, Seoul 137-701 Republic of Korea
C.H. Park
- Department of Surgery, Division of Gastrointestinal Surgery, The Catholic University of Korea, College of Medicine, Seoul, Seoul St. Mary’s Hospital. 505 Banpo-dong, Seocho-gu, Seoul 137-701 Republic of Korea
- Corresponding author. Tel.: +82 2 2258 6099; fax: +82 2 595 2992.

Accepted 12 April 2010.

Abstract

Background

The aim of this study was to clarify the impact of infiltration pattern on prognosis in patients with gastric carcinoma invading subserosa.

Methods

Clinicopathologic findings in patients with ssγ pattern (n = 144) were compared with those in patients with ssα/ssβ cancers (n = 222). Prognostic factors of pT2b patients were analyzed by univariate and multivariate analysis.

Results

Compared with the ssα/β group, ssγ gastric cancer exhibited more frequent undifferentiated histology, disseminated lymph node metastasis and perineural invasion. Frequency of postoperative peritoneal recurrence was significantly higher in ssγ gastric cancer (P < 0.05). The 5-year survival rate for patients with ssγ gastric cancer was significantly lower compared with ssα/β group (63.2% vs. 74.8%, respectively; P < 0.05). Lymph node metastasis, vein invasion and infiltrative pattern (ssγ) were significant independent prognostic factors affecting survival in pT2b patients.