European Journal of Surgical Oncology
Volume 36, Issue 5 , Pages 501-506 , May 2010

The low expression of CD80 correlated with the vascular endothelial growth factor in esophageal cancer tissue

  • W. Yang

      Affiliations

    • Department of Thoracic Surgery, Shandong Cancer Hospital and Institute, Jinan 250117, Shandong Province, China
    • ,
  • Y. Zhang

      Affiliations

    • Department of Thoracic Surgery, Shandong Cancer Hospital and Institute, Jinan 250117, Shandong Province, China
    • ,
  • J. Yu

      Affiliations

    • Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Jinan 250117, Shandong Province, China
    • Corresponding Author InformationCorresponding author. Tel: +86 531 67626971; fax: +86 531 87984079.
    • ,
  • S. Li

      Affiliations

    • Department of Surgery, Shandong Cancer Hospital and Institute, Jinan 250117, Shandong Province, China

,Accepted 18 January 2010.

References 

  1. Zhou J, Zhao LQ, Xiong MM, et al. Gene expression profiles at different stages of human esophageal squamous cell carcinoma. World J Gastroenterol. 2003;9:9–15
  2. Wykes M, Macpherson G. Dendritic cell-B-cell interaction: dendritic cells provide B cells with CD40-independent proliferation signals and CD40-dependent survival signals. Immunology. 2000;100:1–3
  3. Chen SR, Luo YP, Zhang JK, et al. Study on immune function of dendritic cells in patients with esophageal carcinoma. World J Gastroenterol. 2004;10:934–939
  4. TNM classification of malignant tumours . Union Internationale Control Cancer. 6th ed.. New York: Wiley-Liss; 2002;
  5. Omari KI, Dorovini-Zis K. Expression and function of the costimulatory molecules B7-1 (CD80) and B7-2 (CD86) in an in vitro model of the human blood–brain barrier. J Neuroimmunol. 2001;113:129–141
  6. Zhang XH, Zeng ZY. Relationship between quantitative expression of VEGF, P16, CD44v6 in supraglottic squamous cell carcinoma and cervical lymph node metastatic status. Ai Zheng. 2001;20:970–973
  7. Freeman GJ, Freedman AS, Segil JM, et al. B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells. J Immunol. 1989;143:2714–2722
  8. Lapointe R, Bellemare-Pelletier A, Housseau F, et al. CD40-stimulated B lymphocytes pulsed with tumor antigens are effective antigen-presenting cells that can generate specific T cells. Cancer Res. 2003;63:2836–2843
  9. Hoffmann TK, Meidenbauer N, Muller-Berghaus J, et al. Proinflammatory cytokines and CD40 ligand enhance cross-presentation and cross-priming capability of human dendritic cells internalizing apoptotic cancer cells. J Immunother. 2001;24:162–171
  10. Orabona C, Grohmann U, Belladonna ML, et al. CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86. Nat Immunol. 2004;5:1134–1142
  11. Shahinian A, Pfeffer K, Lee KP, et al. Differential T cell costimulatory requirements in CD28-deficient mice. Science. 1993;261:609–612
  12. Chambers CA, Sullivan TJ, Allison JP. Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+T cells. Immunity. 1997;7:885–895
  13. Woods GM, Doherty KV, Malley RC, et al. Carcinogen-modified dendritic cells induce immunosuppression by incomplete T-cell activation resulting from impaired antigen uptake and reduced CD86 expression. Immunology. 2000;99:16–22
  14. Guo G, Chen S, Zhang J, et al. Antitumor activity of a fusion of esophageal carcinoma cells with dendritic cells derived from cord blood. Vaccine. 2005;23:5225–5230
  15. Toi M, Matsumoto T, Bando H. Vascular endothelial growth factor: its prognostic, predictive, and therapeutic implications. Lancet Oncol. 2001;2:667–673
  16. Shih CH, Ozawa S, Ando N, et al. Vascular endothelial growth factor expression predicts outcome and lymph node metastasis in squamous cell carcinoma of the esophagus. Clin Cancer Res. 2000;6:1161–1168
  17. Kleespies A, Guba M, Jauch KW, et al. Vascular endothelial growth factor in esophageal cancer. J Surg Oncol. 2004;87:95–104
  18. Yamaguchi K, Saito H, Oro S, et al. Expression of inducible nitric oxide synthase is significantly correlated with expression of vascular endothelial growth factor and dendritic cell infiltration in patients with advanced gastric carcinoma. Oncology. 2005;68:471–478
  19. Griffioen AW, Damen CA, Martinotti S, et al. Endothelial intercellular adhesion molecule-1 expression is suppressed in human malignancies: the role of angiogenic factors. Cancer Res. 1996;56:1111–1117
  20. Dirkx AE, Oude Egbrink MG, Kuijpers MJ, et al. Tumor angiogenesis modulates leukocyte-vessel wall interactions in vivo by reducing endothelial adhesion molecule expression. Cancer Res. 2003;63:2322–2329
  21. Takahashi A, Kono K, Ichihara F, et al. Vascular endothelial growth factor inhibits maturation of dendritic cells induced by lipopolysaccharide, but not by proinflammatory cytokines. Cancer Immunol Immunother. 2004;53:543–550
  22. Ohm JE, Carbone DP. VEGF as a mediator of tumor-associated immunodeficiency. Immunol Res. 2001;23:263–272
  23. Oyama T, Ran S, Ishida T, et al. Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-kappa B activation in hemopoietic progenitor cells. J Immunol. 1998;160:1224–1232
  24. Laxmanan S, Robertson SW, Wang E, et al. Vascular endothelial growth factor impairs the functional ability of dendritic cells through Id pathways. Biochem Biophys Res Commun. 2005;334:193–198
  25. Zang X, Allison JP. To be or not to be B7. J Clin Invest. 2006;116:2590–2593
  26. Tafuri A, Shahinian A, Bladt F, et al. ICOS is essential for effective T-helper-cell responses. Nature. 2001;409:105–109
  27. Barber DL, Wherry EJ, Masopust D, et al. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature. 2006;439:682–687
  28. Tseng PH, Lee YC, Chiu HM, et al. Prevalence and clinical characteristics of Barrett's esophagus in a Chinese general population. J Clin Gastroenterol. 2008;42:1074–1079
  29. Abrams JA, Fields S, Lightdale CJ, et al. Racial and ethnic disparities in the prevalence of Barrett's esophagus among patients who undergo upper endoscopy. Clin Gastroenterol Hepatol. 2008;6:30–34
  30. Derong W. Esophageal adenocarcinoma and Barrett's esophagus. Foreign Med Sci Oncol Sect. 2004;31:699–701

PII: S0748-7983(10)00032-6

doi: 10.1016/j.ejso.2010.01.007

European Journal of Surgical Oncology
Volume 36, Issue 5 , Pages 501-506 , May 2010

Article Tools

* Image Usage & Resolution