European Journal of Surgical Oncology
Volume 36, Issue 4 , Pages 350-357 , April 2010

Diagnosing occult tumour cells and their predictive value in sentinel nodes of histologically negative patients with colorectal cancer

  • E.S. van der Zaag

      Affiliations

    • Department of Surgery, Gelre Ziekenhuizen, Albert Schweitzerlaan 31, 7334 DZ Apeldoorn, The Netherlands
    • Corresponding Author InformationCorresponding author. Tel.: +31 55 8446016.
    • ,
  • N. Kooij

      Affiliations

    • Department of Pathology, Gelre Ziekenhuizen, Apeldoorn, The Netherlands
    • ,
  • M.J. van de Vijver

      Affiliations

    • Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands
    • ,
  • W.A. Bemelman

      Affiliations

    • Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands
    • ,
  • H.M. Peters

      Affiliations

    • Department of Pathology, Gelre Ziekenhuizen, Apeldoorn, The Netherlands
    • ,
  • C.J. Buskens

      Affiliations

    • Department of Surgery, Gelre Ziekenhuizen, Albert Schweitzerlaan 31, 7334 DZ Apeldoorn, The Netherlands

,Accepted 16 November 2009.

References 

  1. Matter M, Winckler M, Aellen S, Bouzourene H. Detection of metastatic disease with sentinel lymph node dissection in colorectal carcinoma patients. Eur J Surg Oncol. 2007;33:1183–1190
  2. Kelder W, Braat AE, Karrenbeld A, et al. The sentinel node procedure in colon carcinoma: a multi-centre study in The Netherlands. Int J Colorectal Dis. 2007;22:1509–1514
  3. Bembenek AE, Rosenberg R, Wagler E, et al. Sentinel lymph node biopsy in colon cancer: a prospective multicenter trial. Ann Surg. 2007;245:858–863
  4. Stojadinovic A, Nissan A, Protic M, et al. Prospective randomized study comparing sentinel lymph node evaluation with standard pathologic evaluation for the staging of colon carcinoma: results from the United States Military Cancer Institute Clinical Trials Group Study G1-01. Ann Surg. 2007;245:864–866
  5. Van Schaik PM, Van der Linden JC, Ernst MF, Gelderman WA, Bosscha K. Ex vivo sentinel lymph node “mapping” in colorectal cancer. Eur J Surg Oncol. 2007;33:1177–1182
  6. Bianchi PP, Ceriani C, Rottoli M, et al. Laparoscopic lymphatic mapping and sentinel lymph node detection in colon cancer: technical aspects and preliminary results. Surg Endosc. 2007;21:1567–1571
  7. Thomas KA, Lechner J, Shen P, Waters GS, Geisinger KR, Levine EA. Use of sentinel node mapping for cancer of the colon: ‘to map or not to map’. Am Surg. 2006;72:606–611
  8. Smith J, Hwang H, Wiseman KW, Filipenko D, Phang PT. Ex vivo sentinel lymph node mapping in colon cancer: improving the accuracy of pathologic staging?. Am J Surg. 2006;191:665–668
  9. Saha S, Seghal R, Patel M, et al. A multicenter trial of sentinel lymph node mapping in colorectal cancer: prognostic implications for nodal staging and recurrence. Am J Surg. 2006;191:305–310
  10. Codignola C, Zorzi F, Zaniboni A, et al. Is there any role for sentinel node mapping in colorectal cancer staging? Personal experience and review of the literature. Jpn J Clin Oncol. 2005;35:645–650
  11. Braat AE, Oosterhuis JW, Moll FC, de Vries JE, Wiggers T. Sentinel node detection after preoperative short-course radiotherapy in rectal carcinoma is not reliable. Br J Surg. 2005;92:1533–1538
  12. Cox ED, Kellicut D, Adair C, Marley K, Otchy DP, Peoples GE. Sentinel lymph node evaluation is technically feasible and may improve staging in colorectal cancer. Curr Surg. 2002;59:301–306
  13. Smith FM, Coffey JC, Khasri NM, et al. Sentinel nodes are identifiable in formalin- fixed specimens after surgeon-performed ex vivo sentinel lymph node mapping in colorectal cancer. Ann Surg Oncol. 2005;12:504–509
  14. Bell SW, Mourra N, Flejou JF, Parc R, Tiret E. Ex vivo sentinel lymph node mapping in colorectal cancer. Dis Colon Rectum. 2005;48:74–79
  15. Paramo JC, Summerall J, Poppiti R, Mesko TW. Validation of sentinel node mapping in patients with colon cancer. Ann Surg Oncol. 2002;9:529–531
  16. Fitzgerald TL, Khalifa MA, Al Zahrani M, Law CH, Smith AJ. Ex vivo sentinel lymph node biopsy in colorectal cancer: a feasibility study. J Surg Oncol. 2002;80:27–32
  17. Bendavid Y, Latulippe JF, Younan RJ, et al. Phase I study on sentinel lymph node mapping in colon cancer: a preliminary report. J Surg Oncol. 2002;7981–7984
  18. Joosten JJ, Strobbe LJ, Wauters CA, Pruszczynski M, Wobbes T, Ruers TJ. Intraoperative lymphatic mapping and the sentinel node concept in colorectal carcinoma. Br J Surg. 1999;86:482–486
  19. Bilchik AJ, Hoon DS, Saha S, et al. Prognostic impact of micrometastases in colon cancer: interim results of a prospective multicenter trial. Ann Surg. 2007;246:568–575
  20. Bertagnolli M, Miedema B, Redston M, et al. Sentinel node staging of resectable colon cancer: results of a multicenter study. Ann Surg. 2004;240:624–628
  21. Faerden AE, Sjo OH, Andersen SN, et al. Sentinel node mapping does not improve staging of lymph node metastasis in colonic cancer. Dis Colon Rectum. 2008;51:891–896
  22. Yagci G, Unlu A, Kurt B, et al. Detection of micrometastases and skip metastases with ex vivo sentinel node mapping in carcinoma of the colon and rectum. Int J Colorectal Dis. 2007;22:167–173
  23. Bembenek A, Schneider U, Gretschel S, Fischer J, Schlag PM. Detection of lymph node micrometastases and isolated tumor cells I sentinel and nonsentinel lymph nodes of colon cancer patients. World J Surg. 2005;29:1172–1175
  24. Turner RR, Nora DT, Trocha SD, Bilchik AJ. Frequency and nature of cytokeratin- positive cells in sentinel and nonsentinel lymph nodes. Arch Pathol Lab Med. 2003;127:673–679
  25. Green FL, Page DL, Fleming ID, et al. AJCC cancer staging manual. 6th ed.. New York: Springer; 2002;
  26. Singletary SE, Allred C, Ashley P, et al. Revision of the American Joint Committee on Cancer staging system for breast cancer. J Clin Oncol. 2002;20:3628–3636
  27. Teuch JJ, Pessaux P, Fiore FD, et al. Sentinel node mapping in coloncarcinoma: in-vivo versus ex-vivo approach. Eur J Surg Oncol. 2006;32:158–161
  28. Wood TF, Saha S, Morton DL, et al. Validation of lymphatic mapping in colorectal cancer: in vivo, ex vivo, and laparoscopic techniques. Ann Surg Oncol. 2001;8:150–157
  29. van der Zaag ES, Buskens CJ, Kooij N, et al. Improving staging accuracy in colon and rectal cancer by sentinel lymph node mapping: a comparative study. Eur J Surg Oncol. 2009 Mar 3;
  30. Borgen E, Beiske K, Trachsel S, et al. Immunocytochemical detection of isolated epithelial cells in bone marrow: non-specific staining and contribution by plasma cells directly reactive to alkaline phosphatase. J Pathol. 1998;185:427–434
  31. Redston M, Compton CC, Miedema BW, et al. Analysis of micrometastatic disease in sentinel lymph nodes from resectable colon cancer: results of cancer and leukaemia group B trial 80001. J Clin Oncol. 2006;24:878–883
  32. Messerini L, Cianchi F, Cortesini C, Comin CE. Incidence and prognostic significance of occult tumor cells in lymph nodes from patients with stage IIA colorectal carcinoma. Hum Pathol. 2006;37:1259–1267

PII: S0748-7983(09)00516-2

doi: 10.1016/j.ejso.2009.11.008

European Journal of Surgical Oncology
Volume 36, Issue 4 , Pages 350-357 , April 2010

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