European Journal of Surgical Oncology
Volume 36, Issue 2 , Pages 125-129 , February 2010

Perioperative tumor cell dissemination in patients with primary or metastatic colorectal cancer

  • J.G. Tralhão

      Affiliations

    • Department of Surgery, Surgery 3, Faculty of Medicine, Coimbra University Hospital, Coimbra, Portugal
    • Biophysics and Biomathematics Institute, IBILI, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    • Corresponding Author InformationCorresponding author. Department of Surgery, Surgery 3, Hospitais da Universidade de Coimbra, Praceta Prof. Mota Pinto, 3000-075 Coimbra, Portugal. Tel.: +351 239 400 417; fax: +351 239 480 258.
    • ,
  • E. Hoti

      Affiliations

    • Liver Transplant Unit, Saint Vincent's University Hospital, Elm Park, Dublin 4, Ireland
    • ,
  • M. Serôdio

      Affiliations

    • Department of Surgery, Surgery 3, Faculty of Medicine, Coimbra University Hospital, Coimbra, Portugal
    • ,
  • P. Laranjeiro

      Affiliations

    • Center of Histocompatibility of Center, Coimbra, Portugal
    • ,
  • A. Paiva

      Affiliations

    • Center of Histocompatibility of Center, Coimbra, Portugal
    • ,
  • A.M. Abrantes

      Affiliations

    • Biophysics and Biomathematics Institute, IBILI, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    • ,
  • M.L. Pais

      Affiliations

    • Center of Histocompatibility of Center, Coimbra, Portugal
    • ,
  • M.F. Botelho

      Affiliations

    • Biophysics and Biomathematics Institute, IBILI, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    • ,
  • F. Castro Sousa

      Affiliations

    • Department of Surgery, Surgery 3, Faculty of Medicine, Coimbra University Hospital, Coimbra, Portugal

,Accepted 2 July 2009.

References 

  1. Feldman M, Friedman LS, Sleisenger MH, Feldman M, Scharschmidt BF. Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology/Diagnosis/Management. 7th ed. Philadelphia: WB Saunders; 2002.
  2. Goldberg RM, Fleming TR, Tangen CM, Moertel CG, Macdonald JS, Haller DG. Surgery for recurrent colon cancer: strategies for identifying resectable recurrence and success rates after resection. Eastern Cooperative Oncology Group, the North Central Cancer Treatment Group, and the Southwest Oncology Group Ann Intern Med. 1998;129:27–35
  3. Jen J, Kim H, Piantadosi S, Liu ZF, Levitt RC, Sistonen P. Allelic loss of chromosome 18q and prognosis in colorectal cancer. N Engl J Med. 1994;331:213–221
  4. Laurent-Puig P, Olschwang S, Delattre O, Remvikos Y, Asselain B, Melot T. Survival and acquired genetic alterations in colorectal cancer. Gastroenterology. 1992;102:1136–1141
  5. Gryfe R, Kim H, Hsieh ET, Aronson MD, Holowaty EJ, Bull SB. Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer. N Engl J Med. 2000;342:69–77
  6. Yamaguchi K, Takagi Y, Aoki S, Futamura M, Saji S. Significant detection of circulating cancer cells in the blood by reverse transcriptase-polymerase chain reaction during colorectal cancer resection. Ann Surg. 2000;232:58–65
  7. Weitz J, Koch M, Kienle P, Schrödel A, Willeke F, Benner A. Detection of hematogenic tumor cell dissemination in patients undergoing resection of liver metastases of colorectal cancer. Ann Surg. 2000;232:66–72
  8. Moertel CG. Chemotherapy for colorectal cancer. N Engl J Med. 1994;330:1136–1142
  9. Ho SB, Hyslop A, Albrecht R, Jacobson A, Spencer M, Rothenberger DA. Quantification of colorectal cancer micrometastases in lymph nodes by nested and real-time reverse transcriptase-PCR analysis for carcinoembryonic antigen. Clin Cancer Res. 2004;10:5777–5784
  10. Kell MR, Winter DC, O'Sullivan GC, Shanahan F, Redmond HP. Biological behaviour and clinical implications of micrometastases. Br J Surg. 2000;87:1629–1639
  11. Maruthachalam K, Lash GE, Shenton BK, Horgan AF. Tumour cell dissemination following endoscopic stent insertion. Br J Surg. 2007;94:1151–1154
  12. Guller U, Zajac P, Schnider A, Bösch B, Vorburger S, Zuber M. Disseminated single tumor cells as detected by real-time quantitative polymerase chain reaction represent a prognostic factor in patients undergoing surgery for colorectal cancer. Ann Surg. 2002;236:768–775discussion 775–766
  13. Iinuma H, Okinaga K, Egami H, Mimori K, Hayashi N, Nishida K. Usefulness and clinical significance of quantitative real-time RT-PCR to detect isolated tumor cells in the peripheral blood and tumor drainage blood of patients with colorectal cancer. Int J Oncol. 2006;28:297–306
  14. Koch M, Kienle P, Hinz U, Antolovic D, Schmidt J, Herfarth C. Detection of hematogenous tumor cell dissemination predicts tumor relapse in patients undergoing surgical resection of colorectal liver metastases. Ann Surg. 2005 Feb;241(2):206–207
  15. Riethdorf S, Wikman H, Pantel K. Review: biological relevance of disseminated tumor cells in cancer patients. Int J Cancer. 2008;123:1991–2006
  16. Al-Mawali A, Gillis D, Lewis I. The role of multiparameter flow cytometry for detection of minimal residual disease in acute myeloid leukemia. Am J Clin Pathol. 2009;131:16–26
  17. Johnson PW, Burchill SA, Selby PJ. The molecular detection of circulating tumour cells. Br J Cancer. 1995;72:268–276
  18. Kerst G, Kreyenberg H, Roth C, Well C, Dietz K, Coustan-Smith E. Concurrent detection of minimal residual disease (MRD) in childhood acute lymphoblastic leukaemia by flow cytometry and real-time PCR. Br J Haematol. 2005;128:774–782
  19. Rawstron AC, Kennedy B, Evans PA, Davies FE, Richards SJ, Haynes AP. Quantitation of minimal disease levels in chronic lymphocytic leukemia using a sensitive flow cytometric assay improves the prediction of outcome and can be used to optimize therapy. Blood. 2001;98:29–35
  20. Cruz I, Ciudad J, Cruz JJ, Ramos M, Gómez-Alonso A, Adansa JC. Evaluation of multiparameter flow cytometry for the detection of breast cancer tumor cells in blood samples. Am J Clin Pathol. 2005;123:66–74
  21. Stefansson IM, Salvesen HB, Akslen LA. Loss of p63 and cytokeratin 5/6 expression is associated with more aggressive tumors in endometrial carcinoma patients. Int J Cancer. 2006;118:1227–1233
  22. Ciudad J, San Miguel JF, Lopez-Berges MC, Vidriales B, Valverde B, Ocqueteau M. Prognostic value of immunophenotypic detection of minimal residual disease in acute lymphoblastic leukemia. J Clin Oncol. 1998;16:3774–3781
  23. Maloum K, Charlotte F, Divine M, Cazin B, Lesty C, Merle-Beral H. A comparison of the sensitivity of flow cytometry and bone marrow biopsy in the detection of minimal residual disease in chronic lymphocytic leukemia. Haematologica. 2006;91:860–861
  24. Jacques N, Vimond N, Conforti R, Griscelli F, Lecluse Y, Laplanche A. Quantification of circulating mature endothelial cells using a whole blood four-color flow cytometric assay. J Immunol Methods. 2008;337:132–143
  25. Smiler D, Soltan M, Albitar M. Toward the identification of mesenchymal stem cells in bone marrow and peripheral blood for bone regeneration. Implant Dent. 2008;17:236–247
  26. Dong Q, Huang J, Zhou Y, Li L, Bao G, Feng J. Hematogenous dissemination of lung cancer cells during surgery: quantitative detection by flow cytometry and prognostic significance. Lung Cancer. 2002;37:293–301
  27. Garcia JA, Rosenberg JE, Weinberg V, Scott J, Frohlich M, Park JW. Evaluation and significance of circulating epithelial cells in patients with hormone-refractory prostate cancer. BJU Int. 2007;99:519–524
  28. Bozzi F, Collini P, Aiello A, Barzanò E, Gambirasio F, Podda M. Flow cytometric phenotype of rhabdomyosarcoma bone marrow metastatic cells and its implication in differential diagnosis with neuroblastoma. Anticancer Res. 2008;28:1565–1569
  29. Alfonso P, Núñez A, Madoz-Gurpide J, Lombardia L, Sánchez L, Casal I. Proteomic expression analysis of colorectal cancer by two-dimensional differential gel electrophoresis. Proteomics. 2005;5:2602–2611
  30. Friedman D, Hill S, Keller J, Merchant NB, Levy SE, Coffey RJ. Proteome analysis of human colon cancer by two-dimensional difference gel electrophoresis and mass spectrometry. Proteomics. 2004;4:793–811
  31. Moll R, Franke WW, Schiller DL, Geiger B, Krepler R. The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell. 1982;31:11–24
  32. Moll R, Zimbelmann R, Goldschmidt MD, Keith M, Laufer J, Kasper M. The human gene encoding cytokeratin 20 and its expression during fetal development and in gastrointestinal carcinomas. Differentiation. 1993;53:75–93
  33. Weitz J, Kienle P, Magener A, Koch M, Schrödel A, Willeke F. Detection of disseminated colorectal cancer cells in lymph nodes, blood and bone marrow. Clin Cancer Res. 1999;5:1830–1836

PII: S0748-7983(09)00225-X

doi: 10.1016/j.ejso.2009.07.003

European Journal of Surgical Oncology
Volume 36, Issue 2 , Pages 125-129 , February 2010

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