European Journal of Surgical Oncology
Volume 35, Issue 12 , Pages 1268-1272 , December 2009

Influence of neoadjuvant radio-chemotherapy on tumor-infiltrating lymphocytes in squamous esophageal cancer

  • U. Zingg

      Affiliations

    • Department of Surgery, University Hospital Basel, Spitalstrasse 21, 4031 Basel, Switzerland
    • Corresponding Author InformationCorresponding author. Tel.: +61 42 325 75 05.
    • Present address: Discipline of Surgery, Royal Adelaide Hospital, Adelaide 5000 SA, Australia.
  • ,
  • M. Montani

      Affiliations

    • Institute of Pathology, Triemli Hospital, 8063 Zurich, Switzerland
  • ,
  • D.M. Frey

      Affiliations

    • Department of Surgery, University Hospital Basel, Spitalstrasse 21, 4031 Basel, Switzerland
  • ,
  • S. Dirnhofer

      Affiliations

    • Institute of Pathology, University Hospital Basel, 4031 Basel, Switzerland
  • ,
  • P. Went

      Affiliations

    • Institute of Pathology, Triemli Hospital, 8063 Zurich, Switzerland
  • ,
  • D. Oertli

      Affiliations

    • Department of Surgery, University Hospital Basel, Spitalstrasse 21, 4031 Basel, Switzerland

,Accepted 2 July 2009.

References 

  1. Hulscher JB, van Sandick JW, de Boer AG, et al. Extended transthoracic resection compared with limited transhiatal resection for adenocarcinoma of the esophagus. N Engl J Med. 2002;347:1662–1669
  2. Lerut T, Nafteux P, Moons J, et al. Three-field lymphadenectomy for carcinoma of the esophagus and gastroesophageal junction in 174 R0 resections: impact on staging, disease-free survival and outcome. Ann Surg. 2004;240:962–974
  3. Zhang L, Conejo-Gracia JR, Katsaros D, et al. Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. N Engl J Med. 2003;348:203–213
  4. Sato E, Olson SH, Ahn J, et al. Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8/regulatory T cell ratio are associated with favourable prognosis in ovarian cancer. Proc Natl Acad Sci U S A. 2005;102:18538–18543
  5. Fukunaga A, Miyamoto M, Cho Y, et al. CD8+ tumor-infiltrating lymphocytes together with CD4+ tumor-infiltration lymphocytes and dendritic cells improve the prognosis of patients with pancreatic adenocarcinoma. Pancreas. 2004;28:e26–e31
  6. Clarke SL, Betts GJ, Plant A, et al. CD4+ CD25+ FoxP3+ regulatory T cells suppress anti-tumor responses in patients with colorectal cancer. PloS One. 2006;1:e129
  7. Cho Y, Miyamoto M, Kato K, et al. CD4+ and CD8+ T cells cooperate to improve prognosis of patients with esophageal squamous cell carcinoma. Cancer Res. 2003;63:1555–1559
  8. Schumacher K, Haensch W, Roefzaad C, et al. Prognostic significance of activated CD8+ T cell infiltrations in esophageal carcinomas. Cancer Res. 2001;61:3932–3936
  9. Ikeguchi M, Saito H, Katano K, et al. Correlation between the lymphocytic infiltration of tumors and the proliferative activity of cancer cells from surgically treated esophageal carcinoma. Oncology. 1997;54:311–317
  10. Sasada T, Kimura M, Yoshida Y, et al. CD4+ CD25+ regulatory T cells in patients with gastrointestinal malignancies. Cancer. 2003;98:1089–1099
  11. Roncador G, Brown PJ, Maestre L, et al. Analysis of FoxP3 protein expression in human CD4+ CD25+ regulatory T cells at single-cell level. Eur J Immunol. 2005;35:1681–1691
  12. Fontenot JD, Gavin MA, Rudensky AY. FoxP3 programs the development and function of CD4+ CD25+ regulatory T cells. Nat Immunol. 2003;4:330–336
  13. Curiel TJ, Coukos G, Zou L, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med. 2004;10:942–949
  14. Wolf D, Wolf AM, Rumpold H, et al. The expression of the regulatory T cell-specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer. Clin Cancer Res. 2005;11:8326–8331
  15. Badoual C, Hans S, Rodriguez J, et al. Prognostic value of tumor-infiltrating CD4+ T-cell subpopulations in head and neck cancers. Clin Cancer Res. 2006;12:465–472
  16. Yoshioka T, Miyamoto M, Cho Y, et al. Infiltrating regulatory T cell numbers is not a factor to predict patient's survival in oesophageal squamous cell cancer. Br J Cancer. 2008;98:1258–1263
  17. Kang DH, Weaver MT, Park NJ, et al. Significant impairment in immune recovery after cancer treatment. Nurs Res. 2009;58:105–114
  18. Ladoire S, Arnould L, Apetoh L, et al. Pathologic complete response to neoadjuvant chemotherapy of breast carcinoma is associated with the disappearance of tumor-infiltrating foxp3+ regulatory T cells. Clin Cancer Res. 2008;14:2413–2420
  19. Yamamoto T, Kimura T, Ueta E, et al. Characteristic cytokine generation patterns in cancer cells and infiltrating lymphocytes in oral squamous cell carcinomas and the influence of chemoradiation combined with immunotherapy on these patterns. Oncology. 2003;64:407–415
  20. Suwa T, Saio M, Umemura N, et al. Preoperative radiotherapy contributes to induction of proliferative activity of CD8+ tumor-infiltrating T-cells in oral squamous cell carcinoma. Oncol Rep. 2006;15:757–763
  21. Schaue D, Comin-Anduix B, Ribas A, et al. T-cell responses to surviving in cancer patients undergoing radiation therapy. Clin Cancer Res. 2008;14:4883–4890
  22. Mandard AM, Dalibard F, Mandard JC, et al. Pathologic assessment of tumor regression after preoperative chemoradiotherapy of esophageal carcinoma. Cancer. 1994;73:2680–2688
  23. Galon J, Costes A, Sanchez-Cabo F, et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science. 2006;313:1960–1964
  24. Cao M, Cabrera R, Xu Y, et al. Gamma irradiation alters the phenotype and function of CD4(+)CD25(+) regulatory T cells. Cell Biol Int. 2009;33:565–571
  25. Mozaffari F, Lindemalm C, Choudhury A, et al. Systemic immune effects of adjuvant chemotherapy with 5-fluorouracil, epirubicin and cyclophosphamide and/or radiotherapy in breast cancer: a longitudinal study. Cancer Immunol Immunother. 2009;58:111–120
  26. Murta EF, de Andrade JM, Falcao RP, et al. Lymphocyte subpopulations in patients with advanced breast cancer submitted to neoadjuvant chemotherapy. Tumori. 2000;86:403–407
  27. Tzankov A, Meier C, Hirschmann P, et al. Correlation of high numbers of intratumoral FOXP3+ regulatory T cells with improved survival in germinal center-like large B-cell lymphoma, follicular lymphoma and classical Hodgkin's lymphoma. Haematologica. 2008;93:193–200
  28. Tzankov A, Bourgau C, Kaiser A, et al. Rare expression of T-cell markers in classical Hodgkin's lymphoma. Mod Pathol. 2005;8:1542–1549

PII: S0748-7983(09)00224-8

doi: 10.1016/j.ejso.2009.07.002

European Journal of Surgical Oncology
Volume 35, Issue 12 , Pages 1268-1272 , December 2009