European Journal of Surgical Oncology
Volume 35, Issue 12 , Pages 1286-1294 , December 2009

Expression patterns of hypoxic markers at the invasive margin of colorectal cancers and liver metastases

  • R. Rajaganeshan

      Affiliations

    • Academic Surgical Unit, St. James's University Hospital, Level 7 Clinical Sciences Building, Leeds, LS9 7TF, UK
    • Corresponding Author InformationCorresponding author. Academic Surgical Unit, Level 7 Clinical Sciences Building, St James's University Hospital, Leeds LS9 7TF, UK. Tel.: +44 113 2065281; fax: +44 113 2449618.
    • ,
  • R. Prasad

      Affiliations

    • Department of Hepatobiliary & Transplant Surgery, St. James's University Hospital, Leeds, LS9 7TF, UK
    • ,
  • P.J. Guillou

      Affiliations

    • Academic Surgical Unit, St. James's University Hospital, Level 7 Clinical Sciences Building, Leeds, LS9 7TF, UK
    • ,
  • N. Scott

      Affiliations

    • Department of Pathology, St. James's University Hospital, Leeds, LS9 7TF, UK
    • ,
  • G. Poston

      Affiliations

    • Liverpool Hepato-Biliary Centre, University Hospital Aintree, Liverpool L9 7AL, UK
    • ,
  • D.G. Jayne

      Affiliations

    • Academic Surgical Unit, St. James's University Hospital, Level 7 Clinical Sciences Building, Leeds, LS9 7TF, UK

,Accepted 22 May 2009.

References 

  1. Anwar S, Frayling IM, Scott NA, Carlson GL. Systematic review of genetic influences on the prognosis of colorectal cancer. British Journal of Surgery. 2004;91(10):1275–1291
  2. Harris AL. Hypoxia—a key regulatory factor in tumour growth. Nature Reviews Cancer. 2002;2(1):38–47
  3. Warburg O. On the origin of cancer cells. Science. 1956;123(3191):309–314
  4. Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis?. Nature Reviews Cancer. 2004;11:891–899
  5. Brizel DM, Scully SP, Harrelson JM, et al. Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Research. 1996;56(5):941–943
  6. Zhong H, De Marzo AM, Laughner E, et al. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Research. 1999;59(22):5830–5835
  7. Krishnamachary B, Berg-Dixon S, Kelly B, et al. Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. Cancer Research. 2003;63(5):1138–1143
  8. Quintero M, Mackenzie N, Brennan PA. Hypoxia-inducible factor 1 (HIF-1) in cancer. European Journal of Surgical Oncology. 2004;30(5):465–468
  9. Jass JR, Love SB, Northover JM. A new prognostic classification of rectal cancer. Lancet. 1987;1(8545):1303–1306
  10. Lunevicius R, Nakanishi H, Ito S, et al. Clinicopathological significance of fibrotic capsule formation around liver metastasis from colorectal cancer. Journal of Cancer Research & Clinical Oncology. 2001;127(3):193–199
  11. Rajaganeshan R, Prasad R, Guillou PJ, et al. The influence of invasive growth pattern and microvessel density on prognosis in colorectal cancer and colorectal liver metastases. British Journal of Cancer. 2007;96(7):1112–1117
  12. Waterworth A, Hanby A, Speirs V. A novel cell array technique for high-throughput, cell-based analysis. In Vitro Cellular & Developmental Biology Animal. 2005;41(7):185–187Aug.
  13. Airley R, Loncaster J, Davidson S, et al. Glucose transporter Glut-1 expression correlates with tumor hypoxia and predicts metastasis-free survival in advanced carcinoma of the cervix. Clinical Cancer Research. 2001;7(4):928–934
  14. Kivela AJ, Kivela J, Saarnio J, Parkkila S. Carbonic anhydrases in normal gastrointestinal tract and gastrointestinal tumours. World Journal of Gastroenterology. 2005;11(2):155–163
  15. Kuwai T, Kitadai Y, Tanaka S, et al. Expression of hypoxia-inducible factor-1alpha is associated with tumor vascularization in human colorectal carcinoma. International Journal of Cancer. 2003;105(2):176–181
  16. Ivanov SV, Kuzmin I, Wei MH, et al. Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel–Lindau transgenes. Proceedings of the National Academy of Sciences of the United States of America. 1998;95(21):12596–12601
  17. Medina RA, Meneses AM, Vera JC, et al. Differential regulation of glucose transporter expression by estrogen and progesterone in Ishikawa endometrial cancer cells. Journal of Endocrinology. 2004;182(3):467–478
  18. Hakimian J, Ismail-Beigi F. Enhancement of glucose transport in clone 9 cells by exposure to alkaline pH: studies on potential mechanisms. Journal of Membrane Biology. 1991;120(1):29–39
  19. Klip A, Tsakiridis T, Marette A, Ortiz PA. Regulation of expression of glucose transporters by glucose: a review of studies in vivo and in cell cultures. FASEB Journal. 1994;8(1):43–53
  20. Hedley D, Pintilie M, Woo J, et al. Carbonic anhydrase IX expression, hypoxia, and prognosis in patients with uterine cervical carcinomas. Clinical Cancer Research. 2003;9(15):5666–5674
  21. Giles RH, Lolkema MP, Snijckers CM, et al. Interplay between VHL/HIF1alpha and Wnt/Beta-catenin pathways during colorectal tumorigenesis. Oncogene. 2006;25(21):3065–3070
  22. Zhuang Z, Emmert-Buck MR, Roth MJ, et al. Von Hippel–Lindau disease gene deletion detected in microdissected sporadic human colon carcinoma specimens. Human Pathology. 1996;27(2):152–156
  23. Calvani M, Trisciuoglio D, Bergamaschi C, Shoemaker RH, Melillo G. Differential involvement of vascular endothelial growth factor in the survival of hypoxic colon cancer cells. Cancer Research. 2008;68(1):285–291
  24. Mizukami Y, Kohgo Y, Chung DC. Hypoxia inducible factor-1 independent pathways in tumor angiogenesis. Clinical Cancer Research. 2007;13(19):5670–5674[Review] [55 Refs]
  25. Chen D, Li M, Luo J, Gu W. Direct interactions between HIF-1 alpha and mdm2 modulate P53 function. Journal of Biological Chemistry. 2003;278(16):13595–13598
  26. Hansson LO, Friedler A, Freund S, Rudiger S, Fersht AR. Two sequence motifs from HIF-1alpha bind to the DNA-binding site of P53. Proceedings of the National Academy of Sciences of the United States of America. 2002;99(16):10305–10309

PII: S0748-7983(09)00173-5

doi: 10.1016/j.ejso.2009.05.008

European Journal of Surgical Oncology
Volume 35, Issue 12 , Pages 1286-1294 , December 2009

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