European Journal of Surgical Oncology
Volume 35, Issue 12 , Pages 1250-1256 , December 2009

Sentinel node imaging in breast cancer using superficial injections: Technical details and observations

  • S.K. Somasundaram

      Affiliations

    • University Department of Surgery, Royal Free and University College Medical School, Pond Street, London NW3 2QG, UK
  • ,
  • D.W. Chicken

      Affiliations

    • University Department of Surgery, Royal Free and University College Medical School, Pond Street, London NW3 2QG, UK
  • ,
  • W.A. Waddington

      Affiliations

    • Institute of Nuclear Medicine, University College London Hospital, 235 Euston Road, London NW1 2BU, UK
  • ,
  • J. Bomanji

      Affiliations

    • Institute of Nuclear Medicine, University College London Hospital, 235 Euston Road, London NW1 2BU, UK
  • ,
  • P.J. Ell

      Affiliations

    • Institute of Nuclear Medicine, University College London Hospital, 235 Euston Road, London NW1 2BU, UK
  • ,
  • M.R.S. Keshtgar

      Affiliations

    • University Department of Surgery, Royal Free and University College Medical School, Pond Street, London NW3 2QG, UK
    • Corresponding Author InformationCorresponding author at: Breast Unit, University Department of Surgery, Royal Free Hospital, Pond Street, London NW3 2QG, UK. Tel.: +442078302966x34651; fax: +442073177608.

,Accepted 18 May 2009.

References 

  1. Zavagno G, De Salvo GL, Scalco G, et al. A randomized clinical trial on sentinel lymph node biopsy versus axillary lymph node dissection in breast cancer: results of the Sentinella/GIVOM Trial. Ann Surg. 2008;247(2):207–213
  2. Krag DN, Anderson SJ, Julian TB, et al. Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 Randomised Phase III Trial. Lancet Oncol. 2007;8(10):881–888
  3. Veronesi U, Paganelli G, Viale G, et al. A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer. N Engl J Med. 2003;349(6):546–553
  4. Mansel RE, Fallowfield L, Kissin M, et al. Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer: the ALMANAC Trial. J Natl Cancer Inst. 2006;98(9):599–609
  5. Purushotham AD, Upponi S, Klevesath MB, et al. Morbidity after sentinel lymph node biopsy in primary breast cancer: results from a Randomized Controlled Trial. J Clin Oncol. 2005;23(19):4312–4321
  6. Bennett RL, Blanks RG, Patnick J, et al. Results from the UK NHS Breast Screening Programme 2000–05. J Med Screen. 2007;14(4):200–204
  7. MacNeill F, Mansel R, Horgan K, et al. NEW START: the United Kingdom Sentinel Lymph Biopsy Training Programme. A model of how multi-professional training can achieve competent national performance whilst maintaining patient safety. Breast Cancer Res Treat. 2007;106:S233
  8. Chagpar A, Martin RC, Chao C, et al. Validation of subareolar and periareolar injection techniques for breast sentinel lymph node biopsy. Arch Surg. 2004;139(6):614–618
  9. Goyal A, Newcombe RG, Chhabra A, et al. Factors affecting failed localisation and false-negative rates of sentinel of sentinel node biopsy in breast cancer – results of the ALMANAC validation phase. Breast Cancer Res Treat. 2006;99(2):203–208
  10. Cody HS. Clinical aspects of sentinel node biopsy. Breast Cancer Res. 2001;3(2):104–108
  11. Schwartz GF, Guiliano AE, Veronesi U. Proceeding of the consensus conference of the role of sentinel lymph node biopsy in carcinoma or the breast April 19–22, 2001, Philadelphia, PA, USA. Breast J. 2002;8(3):124–138
  12. Goyal A, Newcombe RG, Mansel RE, et al. Role of routine preoperative lymphoscintigraphy in sentinel node biopsy for breast cancer. Eur J Cancer. 2005;41(2):238–243
  13. Beenen E, de Roy van Zuidewijn DB. Patients blue on patent blue: an adverse reaction during four sentinel node procedures. Surg Oncol. 2005;14(4):151–154
  14. Mansouri R, Chicken DW, Keshtgar MR. Allergic reactions to patent blue dye. Surg Oncol. 2006;15(1):58
  15. D'Eredita G, Giardina C, Guerrieri AM, et al. A further validation of subareolar injection technique for breast sentinel lymph node biopsy. Ann Surg Oncol. 2006;13(5):701–707
  16. Kern KA. Concordance and validation study of sentinel lymph node biopsy for breast cancer using subareolar injection of blue dye and Technetium 99m sulfur colloid. J Am Coll Surg. 2002;195(4):467–475
  17. Borgstein PJ, Meijer S, Pijpers R. Intradermal blue dye to identify sentinel lymph-node in breast cancer. Lancet. 1997;349(9066):1668–1669
  18. de Kanter AY, Menke-Pluijmers MB, Henzen-Logmans SC, et al. Reasons for failure to identify positive sentinel nodes in breast cancer patients with significant nodal involvement. Eur J Surg Oncol. 2006;32(5):498–501
  19. Goyal A, Douglas-Jones AG, Newcombe RG, et al. Effect of lymphatic tumor burden on sentinel lymph node biopsy in breast cancer. Breast J. 2005;11(3):188–194
  20. Dauphine CE, Khalkhali I, Vargas MP, et al. Intraoperative injection of Technetium-99m sulfur colloid is effective in the detection of sentinel lymph nodes in breast cancer. Am J Surg. 2006;192(4):423–426
  21. Wang L, Yu JM, Wang YS, et al. Preoperative lymphoscintigraphy predicts the successful identification but is not necessary in sentinel lymph nodes biopsy in breast cancer. Ann Surg Oncol. 2007;14(8):2215–2220
  22. Holwitt DM, Swatske ME, Gillanders WE, et al. Scientific presentation award: the combination of axillary ultrasound and ultrasound-guided biopsy is an accurate predictor of axillary stage in clinically node-negative breast cancer patients. Am J Surg. 2008;196(4):477–482
  23. Britton PD, Goud A, Godward S, et al. Use of ultrasound-guided axillary node core biopsy in staging of early breast cancer. Eur Radiol. 2008;

PII: S0748-7983(09)00171-1

doi: 10.1016/j.ejso.2009.05.006

European Journal of Surgical Oncology
Volume 35, Issue 12 , Pages 1250-1256 , December 2009