European Journal of Surgical Oncology
Volume 35, Issue 12 , Pages 1257-1260 , December 2009

The significance of immunohistochemistry positivity in sentinel nodes which are negative on haematoxylin and eosin in breast cancer

  • S. Mac Giobuin

      Affiliations

    • Departments of Breast and Endocrine Surgery, St Vincents University Hospital, Elm Park, Dublin 4, Ireland
    • Corresponding Author InformationCorresponding author. Tel.: +353 (1) 2094925; fax: +353 (1) 2693479.
    • ,
  • D.O. Kavanagh

      Affiliations

    • Departments of Breast and Endocrine Surgery, St Vincents University Hospital, Elm Park, Dublin 4, Ireland
    • ,
  • E. Myers

      Affiliations

    • Departments of Breast and Endocrine Surgery, St Vincents University Hospital, Elm Park, Dublin 4, Ireland
    • ,
  • A.O. Doherty

      Affiliations

    • Department of Radiology, St Vincents University Hospital, Elm Park, Dublin 4, Ireland
    • ,
  • C.M. Quinn

      Affiliations

    • Department of Histopathology, St Vincents University Hospital, Elm Park, Dublin 4, Ireland
    • ,
  • T. Crotty

      Affiliations

    • Department of Histopathology, St Vincents University Hospital, Elm Park, Dublin 4, Ireland
    • ,
  • D. Evoy

      Affiliations

    • Departments of Breast and Endocrine Surgery, St Vincents University Hospital, Elm Park, Dublin 4, Ireland
    • ,
  • E. McDermott

      Affiliations

    • Departments of Breast and Endocrine Surgery, St Vincents University Hospital, Elm Park, Dublin 4, Ireland

,Accepted 1 April 2009.

References 

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  2. Lin PP, Alison DC, Wainstock J, et al. Impact of axillary lymph node dissection on the therapy of breast cancer patients. J Clin Oncol. 1993;11:1536–1544
  3. Giuliano AE. Sentinel lymphadenectomy in primary breast carcinoma: an alternative to routine axillary dissection. J Surg Oncol. 1996;62:75–76
  4. Turner RR, Giuliano AE, Hoon DS, et al. Pathological examination of sentinel lymph node for breast carcinoma. World J Surg. 2001;25:798–805
  5. Hansen NW, Grube BJ, Te W, et al. Clinical significance of axillary metastases in breast cancer: how small is too small?. Proc Am Soc Clin Oncol. 2001;20:91
  6. Wilkinson EJ, Hause LL, Hoffman RG, et al. Occult axillary lymph node metastases in invasive breast carcinoma: characteristics of the primary tumor and significance of metastases. Pathol Annu. 1982;17:67–91
  7. Moore KH, Thaler HT, Tan LK, et al. Immunohistochemically detected tumour cells in the sentinel nodes of patients with breast carcinoma. Biologic metastasis or procedural artefact?. Cancer. 2004;100(5):929–935
  8. Van der Ploeg IM, Kroon BB, Antonini N, et al. Axillary and extra-axillary lymph node recurrences after a tumor-negative sentinel node biopsy for breast cancer using intralesional tracer administration. Ann Surg Oncol. 2008;15(4):1025–1031
  9. Dowling CM, Hill AD. Sentinel lymph node biopsy in breast cancer. Surgeon. 2004;2(5):273–276
  10. Jakub JW, DIAZ NM, Ebert MD, et al. Completion axillary lymph node dissection minimises the likelihood of false negatives for patients with invasive breast carcinoma and cytokeratin positive only sentinel lymph nodes. Am J Surg. 2002;184:302–306
  11. Eifel A, Axelson JA, Costa JA. National institute of health consensus development conference statement: adjuvant therapy for breast cancer. J Natl Cancer Inst. 2001;93:979–989
  12. Gadd M, Harris J, Taghian A, et al. Prospective study of axillary radiation without axillary dissection for breast cancer patients with a positive sentinel lymph node. Presented at the Annual San Antonio Breast Cancer Symposium, San Antonio, Texas, December 8–11, 2005, Abstract 22.
  13. Hwang RF, Gonzalez-Angulo AM, Yi M, et al. Low locoregional failure rates in selected breast cancer patients with tumor positive sentinel lymph nodes who do not undergo completion axillary dissection. Cancer. 2007;110(4):725–731
  14. Tan LK, Giri D, Hummer AJ, et al. Occult axillary node metastases in breast cancer are prognostically significant: results in 368 node-negative patients with 20-year follow-up. J Clin Oncol. 2008;26(11):1803–1809

PII: S0748-7983(09)00118-8

doi: 10.1016/j.ejso.2009.04.004

European Journal of Surgical Oncology
Volume 35, Issue 12 , Pages 1257-1260 , December 2009

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