European Journal of Surgical Oncology
Volume 35, Issue 10 , Pages 1071-1077 , October 2009

Local recurrence in rectal cancer can be predicted by histopathological factors

  • R.C. Dresen

      Affiliations

    • Department of Surgery, Catharina Hospital Eindhoven, Michelangelolaan 2, 5623 EJ Eindhoven, The Netherlands
    • Department of Radiology, Maastricht University Medical Centre, P. Debyelaan 25, 6229 HX Maastricht, The Netherlands
    • Corresponding Author InformationCorresponding author. Maastricht University Medical Centre, Postbus 5800, 6202 AZ Maastricht, The Netherlands. Tel.: +31 (0)43 387 6910; fax: +31 (0)43 387 6909.
    • ,
  • E.E.M. Peters

      Affiliations

    • Department of Pathology, Radboud University Medical Centre, Geert-Grooteplein-Zuid 10, 6525 GA Nijmegen, The Netherlands
    • ,
  • H.J.T. Rutten

      Affiliations

    • Department of Surgery, Catharina Hospital Eindhoven, Michelangelolaan 2, 5623 EJ Eindhoven, The Netherlands
    • ,
  • G.A.P. Nieuwenhuijzen

      Affiliations

    • Department of Surgery, Catharina Hospital Eindhoven, Michelangelolaan 2, 5623 EJ Eindhoven, The Netherlands
    • ,
  • T.B.J. Demeyere

      Affiliations

    • Department of Pathology, PAMM Laboratories, Michelangelolaan 2, 5623 EJ Eindhoven, The Netherlands
    • ,
  • A.J.C. van den Brule

      Affiliations

    • Department of Pathology, PAMM Laboratories, Michelangelolaan 2, 5623 EJ Eindhoven, The Netherlands
    • ,
  • A.G.H. Kessels

      Affiliations

    • Department of Epidemiology, Maastricht University Medical Centre, P. Debyelaan 25, 6202 AZ Maastricht, The Netherlands
    • ,
  • R.G.H. Beets-Tan

      Affiliations

    • Department of Radiology, Maastricht University Medical Centre, P. Debyelaan 25, 6229 HX Maastricht, The Netherlands
    • ,
  • J.H.J.M. van Krieken

      Affiliations

    • Department of Pathology, Radboud University Medical Centre, Geert-Grooteplein-Zuid 10, 6525 GA Nijmegen, The Netherlands
    • ,
  • I.D. Nagtegaal

      Affiliations

    • Department of Pathology, Radboud University Medical Centre, Geert-Grooteplein-Zuid 10, 6525 GA Nijmegen, The Netherlands

,Accepted 19 March 2009.

References 

  1. Heald RJ, Husband EM, Ryall RD. The mesorectum in rectal cancer surgery—the clue to pelvic recurrence?. Br J Surg. 1982;69:613–616
  2. Kapiteijn E, Putter H, van de Velde CJH. Impact of the introduction and training of total mesorectal excision on recurrence and survival in rectal cancer in The Netherlands. Br J Surg. 2002;89:1142–1149
  3. Moran MR, James EC, Rothenberger DA, Goldberg SM. Prognostic value of positive lymph nodes in rectal cancer. Dis Colon Rectum. 1992;35:579–581
  4. Nagtegaal ID, Quirke P. What is the role for the circumferential margin in the modern treatment of rectal cancer?. J Clin Oncol. 2008;26:303–312
  5. Quirke P, Durdey P, Dixon MF, Williams NS. Local recurrence of rectal adenocarcinoma due to inadequate surgical resection. Histopathological study of lateral tumour spread and surgical excision. Lancet. 1986;2:996–999
  6. Bosset JF, Collette L, Calais G, et al. Chemotherapy with preoperative radiotherapy in rectal cancer. N Engl J Med. 2006;355:1114–1123
  7. Collette L, Bosset JF, den Dulk M, et al. Patients with curative resection of cT3–4 rectal cancer after preoperative radiotherapy or radiochemotherapy: does anybody benefit from adjuvant fluorouracil-based chemotherapy? A trial of the European Organisation for Research and Treatment of Cancer Radiation Oncology Group. J Clin Oncol. 2007;25:4379–4386
  8. Quasar Collaborative Group Gray R, Barnwell J, et al. Adjuvant chemotherapy versus observation in patients with colorectal cancer: a randomised study. Lancet. 2007;370:2020–2029
  9. Compton CC. Pathology report in colon cancer: what is prognostically important?. Dig Dis. 1999;17:67–79
  10. Compton CC, Fielding LP, Burgart LJ, et al. Prognostic factors in colorectal cancer. College of American Pathologists Consensus Statement 1999. Arch Pathol Lab Med. 2000;124:979–994
  11. Meguerditchian AN, Bairati I, Lagace R, Harel F, Kibrite A. Prognostic significance of lymphovascular invasion in surgically cured rectal carcinoma. Am J Surg. 2005;189:707–713
  12. Morris M, Platell C, de Boer B, McCaul K, Iacopetta B. Population-based study of prognostic factors in stage II colonic cancer. Br J Surg. 2006;93:866–871
  13. Ptok H, Meyer F, Steinert R, et al. No prognostic impact of isolated lymphovascular invasion after radical resection of rectal cancer—results of a multicenter observational study. Int J Colorectal Dis. 2007;22:749–756
  14. Dresen RC, Gosens MJ, Martijn H, et al. Radical resection after IORT-containing multimodality treatment is the most important determinant for outcome in patients treated for locally recurrent rectal cancer. Ann Surg Oncol. 2008;15:1937–1947
  15. Rutten HJ, Mannaerts GH, Martijn H, Wiggers T. Intraoperative radiotherapy for locally recurrent rectal cancer in The Netherlands. Eur J Surg Oncol. 2000;26(Suppl A):S16–S20
  16. Kapiteijn E, Marijnen CA, Nagtegaal ID, et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med. 2001;345:638–646
  17. Gosens MJ, Klaassen RA, Tan-Go I, et al. Circumferential margin involvement is the crucial prognostic factor after multimodality treatment in patients with locally advanced rectal carcinoma. Clin Cancer Res. 2007;13:6617–6623
  18. Quirke P, Dixon MF. The prediction of local recurrence in rectal adenocarcinoma by histopathological examination. Int J Colorectal Dis. 1988;3:127–131
  19. Stewart CJ, Morris M, de Boer B, Iacopetta B. Identification of serosal invasion and extramural venous invasion on review of Dukes’ stage B colonic carcinomas and correlation with survival. Histopathology. 2007;51:372–378
  20. Freedman LS, Macaskill P, Smith AN. Multivariate analysis of prognostic factors for operable rectal cancer. Lancet. 1984;2:733–736
  21. Minsky BD, Mies C, Rich TA, Recht A. Lymphatic vessel invasion is an independent prognostic factor for survival in colorectal cancer. Int J Radiat Oncol Biol Phys. 1989;17:311–318
  22. Ouchi K, Sugawara T, Ono H, et al. Histologic features and clinical significance of venous invasion in colorectal carcinoma with hepatic metastasis. Cancer. 1996;78:2313–2317
  23. Sternberg A, Amar M, Alfici R, Groisman G. Conclusions from a study of venous invasion in stage IV colorectal adenocarcinoma. J Clin Pathol. 2002;55:17–21
  24. Quirke P, Morris E. Reporting colorectal cancer. Histopathology. 2007;50:103–112
  25. Vass DG, Ainsworth R, Anderson JH, Murray D, Foulis AK. The value of an elastic tissue stain in detecting venous invasion in colorectal cancer. J Clin Pathol. 2004;57:769–772
  26. Dirschmid K, Lang A, Mathis G, Haid A, Hansen M. Incidence of extramural venous invasion in colorectal carcinoma: findings with a new technique. Hum Pathol. 1996;27:1227–1230
  27. Ludeman L, Shepherd NA. Macroscopic assessment and dissection of colorectal cancer resection specimens. Curr Diagnost Pathol. 2006;12:220–230
  28. Heald RJ, Moran BJ, Ryall RD, Sexton R, MacFarlane JK. Rectal cancer: the Basingstoke experience of total mesorectal excision, 1978–1997. Arch Surg. 1998;133:894–899
  29. Peeters KC, Marijnen CA, Nagtegaal ID, et al. The TME trial after a median follow-up of 6years: increased local control but no survival benefit in irradiated patients with resectable rectal carcinoma. Ann Surg. 2007;246:693–701
  30. Kusters M, Marijnen CAM, van de Velde CJH, et al. Patterns of local recurrence in the Dutch TME trial: bad tumor or bad surgery? (submitted for publication).

PII: S0748-7983(09)00106-1

doi: 10.1016/j.ejso.2009.03.007

European Journal of Surgical Oncology
Volume 35, Issue 10 , Pages 1071-1077 , October 2009

Article Tools

* Image Usage & Resolution