Combined liver surgery and RFA for patients with gastroenteropancreatic endocrine tumors presenting with more than 15 metastases to the liver

Elias, D.; Goéré, D.; Leroux, G.; Dromain, C.; Leboulleux, S.; de Baere, Th.; Ducreux, M.; Baudin, E.

doi:10.1016/j.ejso.2009.02.017

« Previous Next »European Journal of Surgical Oncology
Volume 35, Issue 10 , Pages 1092-1097, October 2009

Combined liver surgery and RFA for patients with gastroenteropancreatic endocrine tumors presenting with more than 15 metastases to the liver

D. Elias
- Institut Gustave Roussy, 39 Rue Camille Desmoulins, 94805 Villejuif, Cédex, France
- Department of Surgical Oncology, Université Paris XI, Villejuif, France
- Corresponding author. Department of Surgical Oncology, Institut Gustave Roussy, 39 Rue Camille Desmoulins, 94805 Villejuif, Cédex, France. Tel.: +33 1 42 11 40 85; fax: +33 1 42 11 52 13.
D. Goéré
- Institut Gustave Roussy, 39 Rue Camille Desmoulins, 94805 Villejuif, Cédex, France
- Department of Surgical Oncology, Université Paris XI, Villejuif, France
G. Leroux
- Institut Gustave Roussy, 39 Rue Camille Desmoulins, 94805 Villejuif, Cédex, France
- Department of Surgical Oncology, Université Paris XI, Villejuif, France
C. Dromain
- Institut Gustave Roussy, 39 Rue Camille Desmoulins, 94805 Villejuif, Cédex, France
- Department of Radiology, Université Paris XI, Villejuif, France
S. Leboulleux
- Institut Gustave Roussy, 39 Rue Camille Desmoulins, 94805 Villejuif, Cédex, France
- Service of Nuclear Medicine, Université Paris XI, Villejuif, France
Th. de Baere
- Institut Gustave Roussy, 39 Rue Camille Desmoulins, 94805 Villejuif, Cédex, France
- Department of Radiology, Université Paris XI, Villejuif, France
M. Ducreux
- Institut Gustave Roussy, 39 Rue Camille Desmoulins, 94805 Villejuif, Cédex, France
- Department of Medical Oncology, Université Paris XI, Villejuif, France
E. Baudin
- Institut Gustave Roussy, 39 Rue Camille Desmoulins, 94805 Villejuif, Cédex, France
- Service of Nuclear Medicine, Université Paris XI, Villejuif, France

Accepted 26 February 2009.

Abstract

Aim

The aim of this study was to report the feasibility and early survival results of liver metastases (LM) resection combining cytoreductive surgery and radiofrequency ablation (RFA) during a one-step procedure, in patients presenting more than 15 bilateral LM from well-differentiated endocrine carcinoma. It is an extensive application of the current guidelines.

Methods

In this retrospective review of a prospectively collected database, we used a combination of hepatectomy to treat large or contiguous LM, and extensively used multiple RFA to treat the remaining LM which were smaller than 2.5cm. Patients were selected based on a low natural tumor burden slope, and the technical feasibility of treating all the detectable LM.

Results

From January 2002 to May 2007, 16 patients with a median of 23 LM per patient (mean number: 25.7±12; range16–89) underwent this procedure. A mean of 15±9 LM per patient were surgically removed and a mean of 12±8 (median of 10) LM per patient were RF ablated. No mortality occurred. Morbidity was observed in 11 patients (69%). The 3-year overall survival and disease-free survival rates were similar to those observed in our preliminary series of 47 hepatectomized patients with a median of 7 LM per patient.

Conclusion

This new one-step combined technique allowed us to apply an “upgraded” therapeutic approach to a selection of patients presenting a median of 23 LM per patient and to improve their prognosis, putting it on par with that obtained by conventional hepatectomy.

Keywords: Endocrine tumor, Liver metastases, Hepatectomy, Radiofrequency ablation