European Journal of Surgical Oncology
Volume 35, Issue 3 , Pages 247-251 , March 2009

The reproducibility of histological parameters employed in the novel binary grading systems of endometrial cancer

  • O. Gemer

      Affiliations

    • Department of Obstetrics and Gynecology, Barzilai Medical Center, Ashkelon, Israel
    • Corresponding Author InformationCorresponding author. Department of Obstetrics and Gynecology, Barzilai Medical Center, 3 Histadrut Street, Ashkelon 78306, Israel. Tel.: +972 8 6745180; fax: +972 8 6745331.
    • ,
  • L. Uriev

      Affiliations

    • Pathology Institute, Barzilai Medical Center, Ashkelon, Israel
    • ,
  • M. Voldarsky

      Affiliations

    • Department of Obstetrics and Gynecology, Barzilai Medical Center, Ashkelon, Israel
    • ,
  • M. Gdalevich

      Affiliations

    • Epidemiology Research institute, Medical Center, Ashkelon, Israel
    • ,
  • D. Ben-Dor

      Affiliations

    • Pathology Institute, Barzilai Medical Center, Ashkelon, Israel
    • ,
  • F. Barak

      Affiliations

    • Oncology Institute, Barzilai Medical Center, Ashkelon, Israel
    • ,
  • E.Y. Anteby

      Affiliations

    • Department of Obstetrics and Gynecology, Barzilai Medical Center, Ashkelon, Israel
    • ,
  • O. Lavie

      Affiliations

    • Department of Obstetrics and Gynecology, Carmel Medical Center, Haifa, Israel

,Accepted 21 July 2008.

References 

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  2. Homesley HD, Zaino R. Endometrial cancer: prognostic factors. Semin Oncol. 1994;21:71–78
  3. Jones HW. The importance of grading in endometrial cancer. Gynecol Oncol. 1999;74:1–2
  4. Creasman WT. Announcements: FIGO stages—1988 revision. Gynecol Oncol. 1989;35:125–127
  5. Ronnett BM, Zaino RJ, Ellenson LH, et al. Endometrial carcinoma. In:  Kurman R editors. Blaustein's pathology of the female genital tract. 5th ed.. New York: Springer; 2002;p. 501–559
  6. Taylor RR, Zeller J, Lieberman RW, et al. An analysis of two versus three grades for endometrial carcinoma. Gynecol Oncol. 1999;74:3–6
  7. Lax SF, Kurman RJ, Pizer ES, et al. A binary architectural grading system for uterine endometrial endometrioid carcinoma has superior reproducibility compared with FIGO grading and identifies subsets of advance-stage tumors with favorable and unfavorable prognosis. Am J Surg Pathol. 2000;24:1201–1208
  8. Stenfansson IM, Salvesen HB, Immervoll H, et al. Prognostic impact of histological grade and vascular invasion compared with tumour cell proliferation in endometrial carcinoma of endometrioid type. Histopathology. 2004;44:472–479
  9. Scholten AN, Smit VT, Beerman H, et al. Prognostic significance and interobserver variability of histologic grading systems for endometrial carcinoma. Cancer. 2004;100:764–772
  10. Alkushi A, Abdul-Rahman ZH, Lim P, et al. Description of a noval system for grading of endometrial carcinoma and comparison with existing grading system. Am J Surg Pathol. 2005;29:295–304
  11. Zaino RJ, Kurman RJ, Diana KL, et al. Pathologic models to predict outcome for women with endometrial adenocarcinoma: the importance of the distinction between surgical stage and clinical stage—a Gynecologic Oncology Group Study. Cancer. 1996 Mar 15;77(6):1115–1121
  12. Gemer O, Ben Arie A, Levy T, et al. Lymphvascular space involvement compromises the survival of patients with stage I endometrial cancer: results of a multicenter study. Eur J Surg Oncol. 2007;33:644–647
  13. Scholten AN, Creutzberg CL, Noordijk EM, et al. Long-term outcome in endometrial carcinoma favors a two- instead of a three-tiered grading system. Int J Radiat Oncol Biol Phys. 2002, 15;52:1067–1074
  14. Zaino RJ, Silverberg SG, Norris HJ, et al. The prognostic value of nuclear versus architectural grading in endometrial adenocarcinoma: a Gynecologic Oncology Group Study. Int J Gynecol Pathol. 1994;13:29–36
  15. Nedergaard L, Jacobsen M, Andersen JE. Interobserver agreement for tumour type, grade of differentiation and stage in endometrial carcinomas. APMIS. 1995;103:511–518
  16. Nielsen AL, Thomsen HK, Nyholm HC. Evaluation of the reproducibility of the revised 1988 International Federation of Gynecology and Obstetrics grading system of endometrial cancers with special emphasis on nuclear grading. Cancer. 1991;68:2303–2309

PII: S0748-7983(08)01716-2

doi: 10.1016/j.ejso.2008.07.010

European Journal of Surgical Oncology
Volume 35, Issue 3 , Pages 247-251 , March 2009

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