European Journal of Surgical Oncology
Volume 35, Issue 2 , Pages 129-134 , February 2009

A critical analysis of treatment strategies in desmoid tumours: a review of a series of 106 cases

  • E. Stoeckle

      Affiliations

    • Department of Surgery, Institut Bergonié, Regional Cancer Centre, 229 cours de l'Argonne, 33076 Bordeaux Cedex, France
    • Corresponding Author InformationCorresponding author. Tel.: +33 5 5633 3333; fax: +33 5 5633 3387.
  • ,
  • J.M. Coindre

      Affiliations

    • Department of Pathology, Institut Bergonié, Regional Cancer Centre, 229 cours de l'Argonne, 33076 Bordeaux Cedex, France
  • ,
  • M. Longy

      Affiliations

    • Department of Pathology, Institut Bergonié, Regional Cancer Centre, 229 cours de l'Argonne, 33076 Bordeaux Cedex, France
  • ,
  • M. Bui Nguyen Binh

      Affiliations

    • Department of Pathology, Institut Bergonié, Regional Cancer Centre, 229 cours de l'Argonne, 33076 Bordeaux Cedex, France
  • ,
  • G. Kantor

      Affiliations

    • Department of Radiotherapy, Institut Bergonié, Regional Cancer Centre, 229 cours de l'Argonne, 33076 Bordeaux Cedex, France
  • ,
  • M. Kind

      Affiliations

    • Department of Radiology, Institut Bergonié, Regional Cancer Centre, 229 cours de l'Argonne, 33076 Bordeaux Cedex, France
  • ,
  • C. Tunon de Lara

      Affiliations

    • Department of Surgery, Institut Bergonié, Regional Cancer Centre, 229 cours de l'Argonne, 33076 Bordeaux Cedex, France
  • ,
  • A. Avril

      Affiliations

    • Department of Surgery, Institut Bergonié, Regional Cancer Centre, 229 cours de l'Argonne, 33076 Bordeaux Cedex, France
  • ,
  • F. Bonichon

      Affiliations

    • Department of Nuclear Medicine, Institut Bergonié, Regional Cancer Centre, 229 cours de l'Argonne, 33076 Bordeaux Cedex, France
  • ,
  • B. Nguyen Bui

      Affiliations

    • Department of Medical Oncology, Institut Bergonié, Regional Cancer Centre, 229 cours de l'Argonne, 33076 Bordeaux Cedex, France

,Accepted 17 June 2008.

References 

  1. Posner MC, Shiu MH, Newsome JL, et al. The desmoid tumor: not a benign disease. Arch Surg. 1989;124:191–196
  2. Stojadinovic A, Leung DH, Hoos A, Jaques DP, Lewis JJ, Brennan MF. Analysis of the prognostic significance of microscopic margins in 2,084 localized primary adult soft tissue sarcomas. Ann Surg. 2002;235:424–434
  3. Janinis J, Patriki M, Vini L, Aravantinos G, Whelan JS. The pharmacological treatment of aggressive fibromatosis: a systematic review. Ann Oncol. 2003;14:181–190
  4. Vandevenne JE, de Schepper AM, de Beuckeleer L, et al. New concepts in understanding evolution of desmoid tumors: MR imaging of 30 lesions. Eur Radiol. 1997;7:1013–1019
  5. Spear MA, Jennings LC, Mankin HJ, et al. Individualizing management of aggressive fibromatoses. Int J Radiat Oncol Biol Phys. 1998;40:637–645
  6. Lewis JJ, Boland PJ, Leung DH, Woodruff JM, Brennan MF. The enigma of desmoid tumors. Ann Surg. 1999;229:866–872discussion 872–3
  7. Soravia C, Berk T, McLeod RS, Cohen Z. Desmoid disease in patients with familial adenomatous polyposis. Dis Colon Rectum. 2000;43:363–369
  8. Stoeckle E, Gardet H, Coindre JM, et al. Prospective evaluation of quality of surgery in soft tissue sarcoma. Eur J Surg Oncol. 2006;32:1242–1248
  9. Merchant NB, Lewis JJ, Woodruff JM, Leung DH, Brennan MF. Extremity and trunk desmoid tumors: a multifactorial analysis of outcome. Cancer. 1999;86:2045–2052
  10. Sorenson A, Keller J, Nielsen O, Jensen O. Treatment of aggressive fibromatosis. A retrospective study of 72 patients followed for 1–27years. Acta Orthop Scand. 2002;73:213–219
  11. Gronchi A, Casali PG, Mariani L, et al. Quality of surgery and outcome in extra-abdominal aggressive fibromatosis: a series of patients surgically treated at a single institution. J Clin Oncol. 2003;21:1390–1397
  12. Phillips SR, A'Hern R, Thomas JM. Aggressive fibromatosis of the abdominal wall, limbs and limb girdles. Br J Surg. 2004;91:1624–1629
  13. Leithner A, Gapp M, Leithner K, et al. Margins in extra-abdominal desmoid tumors: a comparative analysis. J Surg Oncol. 2004;86:152–156
  14. Lev D, Kotilingam D, Wei C, et al. Optimizing treatment of desmoid tumors. J Clin Oncol. 2007;25:1785–1791
  15. Bonvalot S, Eldweny H, Haddad V, et al. Extra-abdominal primary fibromatosis: aggressive management could be avoided in a subgroup of patients. Eur J Surg Oncol. 2008;34(4):462–468
  16. Smith AJ, Lewis JJ, Merchant NB, Leung DH, Woodruff JM, Brennan MF. Surgical management of intra-abdominal desmoid tumours. Br J Surg. 2000;87:608–613
  17. Ballo MT, Zagars GK, Pollack A. Radiation therapy in the management of desmoid tumors. Int J Radiat Oncol Biol Phys. 1998;42:1007–1014
  18. Zlotecki RA, Scarborough MT, Morris CG, et al. External beam radiotherapy for primary and adjuvant management of aggressive fibromatosis. Int J Radiat Oncol Biol Phys. 2002;54:177–181
  19. Reitamo JJ, Scheinin TM, Häyry P. The desmoid syndrome. New aspects in the cause, pathogenesis and treatment of the desmoid tumor. Am J Surg. 1986;151:230–237
  20. Nuyttens JJ, Rust PF, Thomas CR, Turrisi AT. Surgery versus radiation therapy for patients with aggressive fibromatosis or desmoid tumors: a comparative review of 22 articles. Cancer. 2000;88:1517–1523
  21. Fallen T, Wilson M, Morlan B, Lindor N. Desmoid tumors-characterization of patients seen at Mayo Clinic 1976–1999. Familial Cancer. 2006;5:191–194
  22. Li M, Cordon-Cardo C, Gerald WL, Rosai J. Desmoid fibromatosis is a clonal process. Hum Pathol. 1996;27:939–943
  23. Tejpar S, Michils G, Denys H, et al. Analysis of Wnt/Beta catenin signalling in desmoid tumors. Acta Gastroenterol Belg. 2005;68:5–9
  24. Leithner A, Gapp M, Radl R, et al. Immunohistochemical analysis of desmoid tumours. J Clin Pathol. 2005;58:1152–1156
  25. Deyrup AT, Tretiakova M, Montag AG. Estrogen receptor-beta expression in extra-abdominal fibromatoses: an analysis of 40 cases. Cancer. 2006;106:208–213
  26. Balducci C, Lilli C, Stabellini G, et al. Human desmoid fibroblasts: matrix metallo-proteinases, their inhibitors and modulation by Toremifene. BMC Cancer. 2005;5:22
  27. Heinrich M, McArthur G, Demetri G, et al. Clinical and molecular studies of the effect of Imatinib on advanced aggressive fibromatosis (desmoid tumor). J Clin Oncol. 2006;24:1195–1203
  28. Poon R, Smits R, Li C, et al. Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor). Oncogene. 2001;20:451–460
  29. Lindor NM, Dozois R, Nelson H, et al. Desmoid tumors in familial adenomatous polyposis: a pilot project evaluating efficacy of treatment with pirfenidone. Am J Gastroenterol. 2003;98:1868–1874
  30. Hansmann A, Adolph C, Vogel T, Unger A, Moeslein G. High-dose tamoxifen and sulindac as first-line treatment for desmoid tumors. Cancer. 2004 Feb 1;100(3):612–620
  31. Sturt NJ, Phillips RK, Clark SK. High-dose tamoxifen and sulindac as first-line treatment for desmoid tumors. Cancer. 2004 Aug 1;101(3):652;author reply 653
  32. Stojadinovic A, Hoos A, Karpoff HM, et al. Soft tissue tumors of the abdominal wall: analysis of disease patterns and treatment. Arch Surg. 2001;136:70–79
  33. Abbas AE, Deschamps C, Cassivi SD, et al. Chest-wall desmoid tumors: results of surgical intervention. Ann Thorac Surg. 2004;78:1219–1223
  34. Grunhagen DJ, de Wilt JH, Verhoef C, van Geel AN, Eggermont AM. TNF-based isolated limb perfusion in unresectable extremity desmoid tumours. Eur J Surg Oncol. 2005;31:912–916
  35. Micke O, Seegenschmiedt MH. German Cooperative Group on Radiotherapy for Benign Diseases. Radiation therapy for aggressive fibromatosis (desmoid tumors): results of a national Patterns of Care Study. Int J Radiat Oncol Biol Phys. 2005;61:882–891

PII: S0748-7983(08)01713-7

doi: 10.1016/j.ejso.2008.06.1495

European Journal of Surgical Oncology
Volume 35, Issue 2 , Pages 129-134 , February 2009