European Journal of Surgical Oncology
Volume 35, Issue 2 , Pages 144-150 , February 2009

Partial breast irradiation with interstitial high-dose-rate brachytherapy in early breast cancer: Results of a phase II prospective study

  • C. Aristei

      Affiliations

    • Institute of Radiation Oncology, University of Perugia, Ospedale Santa Maria della Misericordia, Via Martiri 28, 35 (Villa Capitini), 06129 Perugia, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 075 5784306; fax: +39 075 5783254.
  • ,
  • I. Palumbo

      Affiliations

    • Institute of Radiation Oncology, University of Perugia, Ospedale Santa Maria della Misericordia, Via Martiri 28, 35 (Villa Capitini), 06129 Perugia, Italy
  • ,
  • F. Cucciarelli

      Affiliations

    • Institute of Radiation Oncology, University of Perugia, Ospedale Santa Maria della Misericordia, Via Martiri 28, 35 (Villa Capitini), 06129 Perugia, Italy
  • ,
  • A. Cavalli

      Affiliations

    • Institute of Radiation Oncology, University of Perugia, Ospedale Santa Maria della Misericordia, Via Martiri 28, 35 (Villa Capitini), 06129 Perugia, Italy
  • ,
  • R. Tarducci

      Affiliations

    • Medical Physics Unit, Perugia General Hospital, via Brunamonti 51, 06122 Perugia, Italy
  • ,
  • C. Raymondi

      Affiliations

    • Medical Physics Unit, Perugia General Hospital, via Brunamonti 51, 06122 Perugia, Italy
  • ,
  • E. Perrucci

      Affiliations

    • Institute of Radiation Oncology, University of Perugia, Ospedale Santa Maria della Misericordia, Via Martiri 28, 35 (Villa Capitini), 06129 Perugia, Italy
  • ,
  • A. Cavaliere

      Affiliations

    • Institute of Pathological Anatomy and Histology, University of Perugia, via Brunamonti 51, 06122 Perugia, Italy
  • ,
  • P. Latini

      Affiliations

    • Institute of Radiation Oncology, University of Perugia, Ospedale Santa Maria della Misericordia, Via Martiri 28, 35 (Villa Capitini), 06129 Perugia, Italy
  • ,
  • A. Rulli

      Affiliations

    • Department of Surgery, University of Perugia, via Brunamonti 51, 06122 Perugia, Italy

,Accepted 2 June 2008.

References 

  1. Wallner P, Arthur D, Bartelink H, et al. Workshop on partial breast irradiation: state of the art and the science. Bethesda, MD, December 8–10, 2002 J Natl Cancer Inst. 2004;96:175–184
  2. Arthur DW, Vicini FA. Accelerated partial breast irradiation as a part of breast conservation therapy. J Clin Oncol. 2005;23:1726–1735
  3. Pignol J-P, Keller B, Rakovitch E, Sankreacha R, Easton H, Que W. First report of a permanent breast 103Pd seed implant as adjuvant radiation treatment for early-stage breast cancer. Int J Radiat Oncol Biol Phys. 2006;64:176–181
  4. Kozak KR, Smith BL, Adams J, et al. Accelerated partial-breast irradiation using proton beams: initial clinical experience. Int J Radiat Oncol Biol Phys. 2006;66:691–698
  5. Sauer R, Sautter-Bihl M-L, Budach W, et al. Accelerated partial breast irradiation. Consensus statement of 3 German Oncology Societies. Cancer. 2007;110:1187–1194
  6. Vicini F, Arthur D, Polgar C, Kuske R. Defining the efficacy of accelerated partial breast irradiation: the importance of proper patient selection, optimal quality assurance, and common sense. Int J Radiat Oncol Biol Phys. 2003;57:1210–1213
  7. Arthur DW, Vicini FA, Kuske RR, Wazer DE, Nag S. Accelerated partial breast irradiation: an updated report from the American Brachytherapy Society. Brachytherapy. 2003;2:124–130
  8. Aristei C, Tarducci R, Palumbo I, et al. Computed tomography for excision cavity localization and 3D-treatment planning in partial breast irradiation with high-dose-rate interstitial brachytherapy. Radiother Oncol. 2007; Nov 21;[Epub ahead of print]
  9. Cox JD, Stetz J, Pajak TF. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys. 1995;31:1341–1346
  10. Turesson I, Notter G. The influence of fraction size in radiotherapy on the late normal tissue reaction – I: comparison of the effects of daily and once-a-week fractionation on human skin. Int J Radiat Oncol Biol Phys. 1984;10:593–598
  11. Van Limbergen E. Indications and technical aspects of brachytherapy in breast conserving treatment of breast cancer. Cancer Radiother. 2003;7:107–120
  12. Harris JR, Levene MB, Svensson G, Hellman S. Analysis of cosmetic results following primary radiation therapy for stage I and II carcinoma of the breast. Int J Radiat Oncol Biol Phys. 1979;5:257–261
  13. Lövey K, Fodor J, Major T, et al. Fat necrosis after partial breast irradiation with brachytherapy or electron irradiation versus standard whole-breast radiotherapy—4-year results of a randomized trial. Int J Radiat Oncol Biol Phys. 2007;69:724–731
  14. Silverstein MJ, Lewinsky BS, Waisman JR, et al. Infiltrating lobular carcinoma. Is it different from infiltrating duct carcinoma?. Cancer. 1994;73:1673–1677
  15. Fourquet A, Campana F, Zafrani B, et al. Prognostic factors of breast recurrence in the conservative management of early breast cancer: a 25-year follow-up. Int J Radiat Oncol Biol Phys. 1989;17:719–725
  16. Page DL, Dupont WD, Rogers LW, Jensen RA, Schuyler PA. Continued local recurrence of carcinoma 15–25years after a diagnosis of low grade ductal carcinoma in situ of the breast treated only by biopsy. Cancer. 1995;76:1197–1200
  17. King TA, Bolton JS, Kuske RR, Fuhrman GM, Scroggins TG, Jiang XZ. Long-term results of wide-field brachytherapy as the sole method of radiation therapy after segmental mastectomy for Tis,1,2 breast cancer. Am J Surg. 2000;180:299–304
  18. van Limbergen E, van den Bogaert W, van der Schueren E, Rijnders A. Tumor excision and radiotherapy as primary treatment of breast cancer. Analysis of patients and treatment parameters and local control. Radiother Oncol. 1987;8:1–9
  19. Arthur DW, Koo D, Zwicker RD, et al. Partial breast brachytherapy after lumpectomy: low-dose-rate and high-dose-rate experience. Int J Radiat Oncol Biol Phys Phys. 2003;56:681–689
  20. Chen PY, Vicini FA, Benitez P, et al. Long-term cosmetic results and toxicity after accelerated partial-breast irradiation. A method for radiation delivery by interstitial brachytherapy for the treatment of early-stage breast carcinoma. Cancer. 2006;106:991–999
  21. Kuske RR, Winter K, Arthur DW, et al. Phase II trial of brachytherapy alone after lumpectomy for select breast cancer: toxicity analysis of RTOG 95-17. Int J Radiat Oncol Biol Phys. 2006;65:45–51
  22. Wazer DE, Lowther D, Boyle T, et al. Clinically evident fat necrosis in women treated with high-dose-rate brachytherapy alone for early-stage breast cancer. Int J Radiat Oncol Biol Phys. 2001;50:107–111
  23. Polgár C, Major T, Fodor J, et al. High-dose-rate brachytherapy alone versus whole breast radiotherapy with or without tumor bed boost after breast-conserving surgery: seven-year results of a comparative study. Int J Radiat Oncol Biol Phys. 2004;60:1173–1181
  24. Wazer DE, Berle L, Graham R, et al. Preliminary results of a phase I–II study of HDR brachytherapy alone for T1/T2 breast cancer. Int J Radiat Oncol Biol Phys. 2002;53:889–897
  25. Polgár C, Fodor J, Major T, et al. Breast-conserving treatment with partial or whole breast irradiation for low-risk invasive breast carcinoma—5-year results of a randomized trial. Int J Radiat Oncol Biol Phys. 2007;69:694–702
  26. Ott OJ, Hildebrandt G, Pötter R, et al. Accelerated partial breast irradiation with multi-catheter brachytherapy: local control, side effects and cosmetic outcome for 274 patients. Results of the German–Austrian multi-centre trial. Radiother Oncol. 2007;82:281–286
  27. Wazer DE, Kaufman S, Cuttino L, DiPetrillo T, Arthur DW. Accelerated partial breast irradiation: an analysis of variables associated with late toxicity and long-term cosmetic outcome after high-dose-rate interstitial brachytherapy. Int J Radiat Oncol Biol Phys. 2006;64:489–495
  28. Narayanan SS, Goel V, Sarin R, et al. Intraoperative high-dose-rate 192Ir radical implant in early breast cancer: a quality assurance and dosimetry study. Int J Radiat Oncol Biol Phys. 2003;56:690–696
  29. Perera F, Engel Y, Holliday R, et al. Local resection and brachytherapy confined to the lumpectomy site for early breast cancer: a pilot study. J Surg Oncol. 1997;65:263–268
  30. Vicini FA, Chen PY, Fraile M, et al. Low-dose-rate brachytherapy as the sole radiation modality in the management of patients with early-stage breast cancer treated with breast-conserving therapy: preliminary results of a pilot study. Int J Radiat Oncol Biol Phys. 1997;38:301–310

PII: S0748-7983(08)00194-7

doi: 10.1016/j.ejso.2008.06.002

European Journal of Surgical Oncology
Volume 35, Issue 2 , Pages 144-150 , February 2009