European Journal of Surgical Oncology
Volume 34, Issue 11 , Pages 1253-1261 , November 2008

Combined expression of the non-receptor protein tyrosine kinases FAK and Src in primary colorectal cancer is associated with tumor recurrence and metastasis formation

  • P. de Heer

      Affiliations

    • Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
  • ,
  • M.M. Koudijs

      Affiliations

    • Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
  • ,
  • C.J.H. van de Velde

      Affiliations

    • Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
  • ,
  • R.I.J.M. Aalbers

      Affiliations

    • Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
  • ,
  • R.A.E.M. Tollenaar

      Affiliations

    • Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
  • ,
  • H. Putter

      Affiliations

    • Department of Medical Statistics, Leiden University Medical Center, Leiden, The Netherlands
  • ,
  • J. Morreau

      Affiliations

    • Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
  • ,
  • B. van de Water

      Affiliations

    • Leiden/Amsterdam Center for Drug Research, Division of Toxicology, Leiden University, Leiden, The Netherlands
  • ,
  • P.J.K. Kuppen

      Affiliations

    • Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands
    • Corresponding Author InformationCorresponding author. Leiden University Medical Center, Department of Surgery, P.O. Box 9600, Albinusdreef 2, 2300 RC, Leiden, The Netherlands, Tel.: +31 71 526 2309; fax: +31 71 526 6750.

,Accepted 7 May 2008.

References 

  1. Webb DJ, Parsons JT, Horwitz AF. Adhesion assembly, disassembly and turnover in migrating cells – over and over and over again. Nat Cell Biol. 2002;4:E97–E100
  2. Mitra SK, Hanson DA, Schlaepfer DD. Focal adhesion kinase: in command and control of cell motility. Nat Rev Mol Cell Biol. 2005;6:56–68
  3. Schlaepfer DD, Hanks SK, Hunter T, van der Geer P. Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature. 1994;372:786–791
  4. Thomas JW, Cooley MA, Broome JM, et al. The role of focal adhesion kinase binding in the regulation of tyrosine phosphorylation of paxillin. J Biol Chem. 1999;274:36684–36692
  5. Bellis SL, Miller JT, Turner CE. Characterization of tyrosine phosphorylation of paxillin in vitro by focal adhesion kinase. J Biol Chem. 1995;270:17437–17441
  6. van Nimwegen MJ, Verkoeijen S, van Buren L, Burg D, van de Water B. Requirement for focal adhesion kinase in the early phase of mammary adenocarcinoma lung metastasis formation. Cancer Res. 2005;65:4698–4706
  7. Hsia DA, Mitra SK, Hauck CR, et al. Differential regulation of cell motility and invasion by FAK. J Cell Biol. 2003;160:753–767
  8. Frisch SM, Vuori K, Ruoslahti E, Chan-Hui PY. Control of adhesion-dependent cell survival by focal adhesion kinase. J Cell Biol. 1996;134:793–799
  9. Oktay MH, Oktay K, Hamele-Bena D, Buyuk A, Koss LG. Focal adhesion kinase as a marker of malignant phenotype in breast and cervical carcinomas. Hum Pathol. 2003;34:240–245
  10. Madan R, Smolkin MB, Cocker R, Fayyad R, Oktay MH. Focal adhesion proteins as markers of malignant transformation and prognostic indicators in breast carcinoma. Hum Pathol. 2006;37:9–15
  11. Kornberg LJ. Focal adhesion kinase and its potential involvement in tumor invasion and metastasis. Head Neck. 1998;20:745–752
  12. Cance WG, Harris JE, Iacocca MV, et al. Immunohistochemical analyses of focal adhesion kinase expression in benign and malignant human breast and colon tissues: correlation with preinvasive and invasive phenotypes. Clin Cancer Res. 2000;6:2417–2423
  13. Owens LV, Xu L, Craven RJ, et al. Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors. Cancer Res. 1995;55:2752–2755
  14. Han NM, Fleming RY, Curley SA, Gallick GE. Overexpression of focal adhesion kinase (p125FAK) in human colorectal carcinoma liver metastases: independence from c-src or c-yes activation. Ann Surg Oncol. 1997;4:264–268
  15. Weiner TM, Liu ET, Craven RJ, Cance WG. Expression of focal adhesion kinase gene and invasive cancer. Lancet. 1993;342:1024–1025
  16. Lark AL, Livasy CA, Calvo B, et al. Overexpression of focal adhesion kinase in primary colorectal carcinomas and colorectal liver metastases: immunohistochemistry and real-time PCR analyses. Clin Cancer Res. 2003;9:215–222
  17. Ayaki M, Komatsu K, Mukai M, et al. Reduced expression of focal adhesion kinase in liver metastases compared with matched primary human colorectal adenocarcinomas. Clin Cancer Res. 2001;7:3106–3112
  18. Sood AK, Coffin JE, Schneider GB, et al. Biological significance of focal adhesion kinase in ovarian cancer: role in migration and invasion. Am J Pathol. 2004;165:1087–1095
  19. Fujii T, Koshikawa K, Nomoto S, et al. Focal adhesion kinase is overexpressed in hepatocellular carcinoma and can be served as an independent prognostic factor. J Hepatol. 2004;41:104–111
  20. Recher C, Ysebaert L, Beyne-Rauzy O, et al. Expression of focal adhesion kinase in acute myeloid leukemia is associated with enhanced blast migration, increased cellularity, and poor prognosis. Cancer Res. 2004;64:3191–3197
  21. Itoh S, Maeda T, Shimada M, et al. Role of expression of focal adhesion kinase in progression of hepatocellular carcinoma. Clin Cancer Res. 2004;10:2812–2817
  22. Theocharis SE, Kouraklis GP, Kakisis JD, et al. Focal adhesion kinase expression is not a prognostic predictor in colon adenocarcinoma patients. Eur J Surg Oncol. 2003;29:571–574
  23. Aligayer H, Boyd DD, Heiss MM, et al. Activation of Src kinase in primary colorectal carcinoma: an indicator of poor clinical prognosis. Cancer. 2002;94:344–351
  24. Hanks SK, Ryzhova L, Shin NY, Brabek J. Focal adhesion kinase signaling activities and their implications in the control of cell survival and motility. Front Biosci. 2003;8:d982–d996
  25. Brabletz T, Jung A, Spaderna S, Hlubek F, Kirchner T. Opinion: migrating cancer stem cells – an integrated concept of malignant tumour progression. Nat Rev Cancer. 2005;5:744–749

PII: S0748-7983(08)00167-4

doi: 10.1016/j.ejso.2008.05.003

European Journal of Surgical Oncology
Volume 34, Issue 11 , Pages 1253-1261 , November 2008