European Journal of Surgical Oncology
Volume 35, Issue 4 , Pages 373-379 , April 2009

Vascularized fibula flap reconstruction of the mandible in bisphosphonate-related osteonecrosis

  • P.F. Nocini

      Affiliations

    • Section of Maxillofacial Surgery and Odontostomatology, Verona University Hospital, P.le L.A. Scuro 10, 37134 Verona, Italy
  • ,
  • G. Saia

      Affiliations

    • Unit of Maxillofacial Surgery, Padova University Hospital, Via Giustiniani 2, 35128 Padova, Italy
  • ,
  • G. Bettini

      Affiliations

    • Section of Maxillofacial Surgery and Odontostomatology, Verona University Hospital, P.le L.A. Scuro 10, 37134 Verona, Italy
  • ,
  • M. Ragazzo

      Affiliations

    • Unit of Maxillofacial Surgery, Padova University Hospital, Via Giustiniani 2, 35128 Padova, Italy
  • ,
  • S. Blandamura

      Affiliations

    • Institute of Pathology, Padova University Hospital, Via Gabelli 61, 35128 Padova, Italy
  • ,
  • L. Chiarini

      Affiliations

    • Unit of Dentistry and Maxillofacial Surgery, Modena University Hospital, Via del Pozzo 71, 41100 Modena, Italy
  • ,
  • A. Bedogni

      Affiliations

    • Section of Maxillofacial Surgery and Odontostomatology, Verona University Hospital, P.le L.A. Scuro 10, 37134 Verona, Italy
    • Corresponding Author InformationCorresponding author. Section of Maxillofacial Surgery and Odontostomatology, Department of Biological and Morphological Sciences, University of Verona, Hospital G.B. Rossi, P.le L.A. Scuro, 10, 37134 Verona, Italy. Tel.: +39 045 807 4251; fax: +39 045 820 2142.

,Accepted 3 May 2008.

References 

  1. Ruggiero SL, Mehrotra B, Rosenberg TJ, Engroff SL. Osteonecrosis of the jaws associated with the use of biphosphonates: a review of 63 cases. J Oral Maxillofac Surg. 2004;62:527–534
  2. Marx RE. Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic (letter). J Oral Maxillofac Surg. 2003;61:1115–1118
  3. Migliorati CA, Schubert MM, Peterson DE, Seneda LM. Biphosphonate associated osteonecrosis of mandibular and maxillary bone. Cancer. 2005;104:83–93
  4. Ruggiero SL, Drew SJ. Osteonecrosis of the jaws and bisphosphonate therapy. J Dent Res. 2007;86:1013–1021
  5. Mavrokokki A, Cheng A, Stein B, Goss AN. The nature and incidence of bisphosphonate associated osteonecrosis of the jaws in Australia. J Oral Maxillofac Surgery. 2007;65:415–423
  6. Bamias A, Kastritis E, Bamia C, et al. Osteonecrosis of the jaw in cancer after treatment with biphosphonates: incidence and risk factors. J Clin Oncol. 2005;23:8580–8587
  7. Bagan JV, Murillo J, Yemenez Y, et al. Avascular jaw osteonecrosis in association with cancer chemotherapy: series of 10 cases. J Oral Pathol Med. 2005;34:120–123
  8. Durie BG, Katz M, Crowley J. Osteonecrosis of the jaws and biphosphonates (letter). N Eng J Med. 2005;353:99–102
  9. Zavras AI, Zhu S. Bisphosphonates are associated with increased risk for jaw surgery in medical claims data: is it osteonecrosis?. J Oral Maxillofac Surg. 2006;64:917–923
  10. American Association of Oral and Maxillofacial Surgeons Position Paper on Bisphosphonate-Related Osteonecrosis of the Jaws. J Oral Maxillofac Surg. 2007;65:369–376
  11. Bisphosphonate-Associated Osteonecrosis of the Jaw: Report of a Task Force of the American Society for Bone and Mineral Research. J Bone Miner Res. 2007;22:1479–1491
  12. Ruggiero SL, Fantasia J, Carlson E. Bisphosphonate-related osteonecrosis of the jaw: background and guidelines for diagnosis, staging and management. Oral Surg Oral Med Oral Path Oral Rad Endod. 2006;102:433–441
  13. Bedogni A, Blandamura S, Lokmic Z, et al. Bisphosphonate-associated jawbone osteonecrosis: a correlation between imaging techniques and histopathology. Oral Surg Oral Med Oral Path Oral Rad Endod. 2008;105:358–364
  14. Farrugia M, Summerlin D-J, Krowiak E, et al. Osteonecrosis of the mandible or maxilla associated with the use of new generation bisphosphonates. Laryngoscope. 2006;116:115–120
  15. Marx RE, Sawatari Y, Fortin M, Broumand V. Bisphosphonate-induced exposed bone (osteonecrosis/osteopetrosis) of the jaws: risk factors, recognition, prevention, and treatment. J Oral Maxillofac Surg. 2005;63:1567–1575
  16. Bedogni A, Ragazzo M, Chiarini L, Nocini PF. Use of a combined protocol to treat bisphosphonate-associated jawbone osteomyelitis: a 12-month follow-up. J Cranio Maxillofac Surg. 2006;34(1):34
  17. Agrillo A, Ungari C, Filiaci F, Priore P, Iannetti G. Ozone therapy in the treatment of avascular bisphosphonate-related jaw osteonecrosis. J Craniofac Surg. 2007;18:1071–1075
  18. Vescovi P, Merigo E, Meleti M, Fornaini C, Nammour S, Manfredi M. Nd:YAG laser biostimulation of bisphosphonate-associated necrosis of the jawbone with and without surgical treatment. Br J Oral Maxillofac Surg. 2007;45:628–632
  19. Farrugia MC, Summerlin DJ, Krowiak E, et al. Osteonecrosis of the mandible or maxilla associated with the use of new generation bisphosphonates. Laryngoscope. 2006;116:115–120
  20. Assael LA. New foundations in understanding osteonecrosis of the jaws. J Oral Maxillofac Surg. 2007;62:125
  21. Engroff LS, Kim DD. Treating bisphosphonate osteonecrosis of the jaws: is there a role for resection and vascularised reconstruction?. J Oral Maxillofac Surg. 2007;65:2374–2385
  22. Marx RE, Cillo JE, Ulloa JJ. Oral bisphosphonate-induced osteonecrosis: risk factors, prediction of risk using serum CTX testing, prevention, and treatment. J Oral Maxillofac Surg. 2007;65:2397–2410
  23. Badros A, Weikel D, Salama A, et al. Osteonecrosis of the jaw in multiple myeloma patients: clinical features and risk factors. J Clin Oncol. 2006;24:945–952
  24. Freiberger JJ, Padilla-Burgos R, Choeu AH, et al. Hyperbaric oxygen treatment and bisphosphonate-induced osteonecrosis of the jaw: a case series. J Oral Maxillofac Surg. 2007;65:1321–1327
  25. Buchbinder D, St. Hilaire H. The use of free tissue transfer in advanced osteoradionecrosis of the mandible. J Oral Maxillofac Surg. 2006;64:961–964
  26. Eckardt A, Fokas K. Microsurgical reconstruction in the head and neck region: an 18-year experience with 500 consecutive cases. J Cranio Maxillofac Surg. 2003;31:197–201
  27. Rajan P, Warner A, Quick CRG. Fibular metastasis from renal cell carcinoma masquerading as deep vein thrombosis. BJU Int. 1999;84:735–736
  28. Hsu CC, Chuang YW, Lin CY, Huang YF. Solitary fibular metastasis from lung cancer mimicking stress fracture. Clin Nucl Med. 2006;31:269–271
  29. Mundy GR. Metastases to bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer. 2002;2:584–593
  30. Roodman GD. Mechanism of bone metastasis. N Engl J Med. 2004;350:1655–1664

PII: S0748-7983(08)00166-2

doi: 10.1016/j.ejso.2008.05.002

European Journal of Surgical Oncology
Volume 35, Issue 4 , Pages 373-379 , April 2009