European Journal of Surgical Oncology
Volume 35, Issue 4 , Pages 398-402 , April 2009

Touch imprint cytology with cytokeratin immunostaining versus Papanicolau staining for intraoperative evaluation of sentinel lymph node metastasis in clinically node-negative breast cancer

  • M. Fujishima

      Affiliations

    • Division of Breast and Endocrine Surgery, Department of Surgery, Kinki University School of Medicine, 377-2 Ohno-Higashi, Osakasayama, 589-8511 Osaka, Japan
    • ,
  • M. Watatani

      Affiliations

    • Division of Breast and Endocrine Surgery, Department of Surgery, Kinki University School of Medicine, 377-2 Ohno-Higashi, Osakasayama, 589-8511 Osaka, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 72 366 0221; fax: +81 72 367 7771.
    • ,
  • H. Inui

      Affiliations

    • Division of Breast and Endocrine Surgery, Department of Surgery, Kinki University School of Medicine, 377-2 Ohno-Higashi, Osakasayama, 589-8511 Osaka, Japan
    • ,
  • Y. Hashimoto

      Affiliations

    • Division of Breast and Endocrine Surgery, Department of Surgery, Kinki University School of Medicine, 377-2 Ohno-Higashi, Osakasayama, 589-8511 Osaka, Japan
    • ,
  • N. Yamamoto

      Affiliations

    • Division of Breast and Endocrine Surgery, Department of Surgery, Kinki University School of Medicine, 377-2 Ohno-Higashi, Osakasayama, 589-8511 Osaka, Japan
    • ,
  • T. Hojo

      Affiliations

    • Division of Breast and Endocrine Surgery, Department of Surgery, Kinki University School of Medicine, 377-2 Ohno-Higashi, Osakasayama, 589-8511 Osaka, Japan
    • ,
  • K. Hirai

      Affiliations

    • Division of Breast and Endocrine Surgery, Department of Surgery, Kinki University School of Medicine, 377-2 Ohno-Higashi, Osakasayama, 589-8511 Osaka, Japan
    • ,
  • M. Yamato

      Affiliations

    • Division of Breast and Endocrine Surgery, Department of Surgery, Kinki University School of Medicine, 377-2 Ohno-Higashi, Osakasayama, 589-8511 Osaka, Japan
    • Yamato Clinic, Japan
    • ,
  • H. Shiozaki

      Affiliations

    • Division of Breast and Endocrine Surgery, Department of Surgery, Kinki University School of Medicine, 377-2 Ohno-Higashi, Osakasayama, 589-8511 Osaka, Japan

,Accepted 13 March 2008.

References 

  1. National institutes of health consensus development panel . Consensus statement: treatment of early-stage breast cancer. J Natl Cancer Inst Monographs. 1992;(11):1–5
  2. Fisher B, Jong-Hyeon J, Anderson S, et al. Twenty-five-year follow-up of a randomized trial comparing radical mastectomy, total mastectomy, and total mastectomy followed by irradiation. N Engl J Med. 2002;347:567–575
  3. Lyman Gary H, Giuliano Armando E, Somerfield Mark R, et al. American society of clinical oncology guideline recommendations for sentinel lymph node biopsy in early-stage breast cancer. J Clin Oncol. 2005;23:7703–7720
  4. Veronesi Umeberto, Paganelli Giovanni, Vacle Giusepe, et al. Sentinel-lymph-node biopsy as a staging procedure in breast cancer: update of a randomized controlled study. Lancet Oncol. 2006;7:983–990
  5. Burak WE, Hollenbeck ST, Zervos EE, et al. Sentinel lymph node biopsy results in less postoperative morbidity compared with axillary lymph dissection for breast cancer. Am J Surg. 2002;183(1):23–27
  6. Van Diest PJ, Torrenga H, Borgstein PJ, et al. Reliability of intraoperative frozen section and imprint cytological investigation of sentinel lymph nodes in breast cancer. Histopathology. 1999;35:14–18
  7. Motomura K, Inaji H, Komoike Y, et al. Intraoperative sentinel lymph node examination by imprint cytology and frozen sectioning during breast surgery. Br J Surg. 2000;87:597–601
  8. Pugliese Matthew S, Kohr Jennifer R, Allison Kimberly H, et al. Accuracy of intraoperative imprint cytology of sentinel lymph nodes in breast cancer. Am J Surg. 2006;192:516–519
  9. Salem AA, Douglas-Jones AG, Sweetland HM, et al. Intraoperative evaluation of axillary sentinel lymph nodes using touch imprint cytology and immunohistochemistry. I. Protocol of rapid immunostaining of touch imprints. Eur J Surg Oncol. 2003;29:25–28
  10. Rubio IT, Korourian S, Cowan C, et al. Use of touch preps for intraoperative diagnosis of sentinel lymph node metastases in breast cancer. Ann Surg Oncol. 1998;5:689–694
  11. Schwarts G, Giuliano AE, Veronesi U, et al. Proceedings of the consensus conference on the role of sentinel lymph node biopsy in carcinoma of the breast. Breast J. 2002;8:124–138
  12. Cserni Gabor. Histopathologic examination of the sentinel lymph nodes. Breast J. 2006;12:152–156
  13. Salem AA, Douglas-Jones AG, Sweetland HM, et al. Intraoperative evaluation of axillary sentinel lymph nodes using touch imprint cytology and immunohistochemistry. Part II. Results. Eur J Surg Oncol. 2006;32:484–487
  14. Maiorano Eugenio, Mazzarol Giovanni M, Pruneri Giancarlo, et al. Ectopic breast tissue as a possible cause of false-positive axillary sentinel lymph node biopsies. Am J Surg Pathol. 2003;27:513–518
  15. Bleiweiss IJ, Nagi CS, Jaffer S. Axillary sentinel lymph nodes can be falsely positive due to iatrogenic displacement and transport of benign epithelial cells in patients with breast carcinoma. J Clin Oncol. 2006;24:1978–1979
  16. Turner RR, Ollia DW, Krasne DL, et al. Histopathologic validation of the sentinel lymph node hypothesis for breast carcinoma. Ann Surg. 1997;226:271–278

PII: S0748-7983(08)00107-8

doi: 10.1016/j.ejso.2008.03.004

European Journal of Surgical Oncology
Volume 35, Issue 4 , Pages 398-402 , April 2009

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