Transoral laser surgery for laryngeal cancer: Outcome, complications and prognostic factors in 275 patients

Preuss, S.F.; Cramer, K.; Klussmann, J.P.; Eckel, H.E.; Guntinas-Lichius, O.

doi:10.1016/j.ejso.2008.01.012

« Previous Next »European Journal of Surgical Oncology
Volume 35, Issue 3 , Pages 235-240, March 2009

Transoral laser surgery for laryngeal cancer: Outcome, complications and prognostic factors in 275 patients

S.F. Preuss
- Department of Otorhinolaryngology, Head and Neck Surgery, Cologne, School of Medicine, University of Cologne, Joseph Stelzmann Str. 9, 50924 Cologne, Germany
- Corresponding author. Tel.: +49 221 478 4758; fax: +49 221 478 6425.
K. Cramer
- Department of Otorhinolaryngology, Head and Neck Surgery, Cologne, School of Medicine, University of Cologne, Joseph Stelzmann Str. 9, 50924 Cologne, Germany
J.P. Klussmann
- Department of Otorhinolaryngology, Head and Neck Surgery, Cologne, School of Medicine, University of Cologne, Joseph Stelzmann Str. 9, 50924 Cologne, Germany
H.E. Eckel
- Department of Otorhinolaryngology, Head and Neck Surgery, Klagenfurt, Austria
O. Guntinas-Lichius
- Department of Otorhinolaryngology, Head and Neck Surgery, Jena, Germany

Accepted 9 January 2008.

Abstract

Aim

Curative treatment options for laryngeal carcinoma include primary radiation therapy, open surgical techniques and transoral laser surgery (TLS). In the last decade, TLS has become an important tool in the treatment of laryngeal cancer and has become the standard approach in many institutions. The aim of this study was to review the experience of a single center institution with TLS for early and advanced laryngeal cancer.

Methods

We retrospectively analyzed 275 patients who underwent TLS in regard to the survival outcome and surgical complications.

Results

The 5-year disease-free survival estimate was 90.3% and the 10-year disease-free survival estimate was 88.2%. The 5-year larynx preservation rate estimate was 88.2% and the 10-year larynx preservation rate estimate was 87.3%. The disease-free survival was significantly worsened by the variables T and N (p=0.0003; p<0.001, respectively). Two percent of all patients required intraoperative tracheostomy and the rate of minor postoperative complications was 17%. There were no fatal complications.