European Journal of Surgical Oncology
Volume 34, Issue 3 , Pages 263-271 , March 2008

Radical surgery for hilar cholangiocarcinoma

  • S. Jonas

      Affiliations

    • Department of General, Visceral and Transplantation Surgery, Charité Campus Virchow Klinikum, Humboldt-University, Augustenburger Platz 1, 13353 Berlin, Germany
    • Corresponding Author InformationCorresponding author. Present address: Department of Visceral, Transplantation, Thoracic and Vascular Surgery, Universitätsklinikum Leipzig, Liebigstraße 20, D-04103 Leipzig, Germany.
  • ,
  • C. Benckert

      Affiliations

    • Department of General, Visceral and Transplantation Surgery, Charité Campus Virchow Klinikum, Humboldt-University, Augustenburger Platz 1, 13353 Berlin, Germany
  • ,
  • A. Thelen

      Affiliations

    • Department of General, Visceral and Transplantation Surgery, Charité Campus Virchow Klinikum, Humboldt-University, Augustenburger Platz 1, 13353 Berlin, Germany
  • ,
  • E. Lopez-Hänninen

      Affiliations

    • Department of Radiology, Charité Campus Virchow Klinikum, Humboldt-University, Berlin, Germany
  • ,
  • T. Rösch

      Affiliations

    • Central Interdisciplinary Endoscopy, Charité Campus Virchow Klinikum, Humboldt-University, Berlin, Germany
    • Department of Internal Medicine, Charité Campus Virchow Klinikum, Humboldt-University, Berlin, Germany
  • ,
  • P. Neuhaus

      Affiliations

    • Department of General, Visceral and Transplantation Surgery, Charité Campus Virchow Klinikum, Humboldt-University, Augustenburger Platz 1, 13353 Berlin, Germany

,Accepted 26 September 2007.

References 

  1. Okuda K, Kubo Y, Okazaki N, Arishima T, Hashimoto M. Clinical aspects of intrahepatic bile duct carcinoma including hilar carcinoma: a study of 57 autopsy-proven cases. Cancer. 1977;39:232–246
  2. Bhuiya MR, Nimura Y, Kamiya J, et al. Clinicopathologic studies on perineural invasion of bile duct carcinoma. Ann Surg. 1992;215:344–349
  3. Weinbren K, Mutum SS. Pathological aspects of cholangiocarcinoma. J Pathol. 1983;139:217–238
  4. Neuhaus P, Jonas S, Bechstein WO, et al. Extended resections for hilar cholangiocarcinoma. Ann Surg. 1999;230:808–818
  5. Jonas S, Steinmuller T, Neuhaus P. Surgical therapy of tumors at the hepatic hilum. Chirurg. 2001;72(7):775–783
  6. Bismuth H. Surgical anatomy and anatomical surgery of the liver. World J Surg. 1982;6:3
  7. Ebata T, Nagino M, Kamiya J, Uesaka K, Nagasaka T, Nimura Y. Hepatectomy with portal vein resection for hilar cholangiocarcinoma: audit of 52 consecutive cases. Ann Surg. 2003;238(5):720–727
  8. Gerhards MF, van Gulik TM, de Wit LT, Obertop H, Gouma DJ. Evaluation of morbidity and mortality after resection for hilar cholangiocarcinoma—a single center experience. Surgery. 2000;127:395
  9. Nimura Y, Kamiya J, Kondo S, et al. Aggressive preoperative management and extended surgery for hilar cholangiocarcinoma: Nagoya experience. J Hepatobiliary Pancreat Surg. 2000;7:155–162
  10. Makuuchi M, Thai BL, Takayasu K, et al. Preoperative portal embolization to increase safety of major hepatectomy for hilar bile duct carcinoma: a preliminary report. Surgery. 1990;107:521
  11. Hintze RE, Abou-Rebyeh H, Adler A, Veltzke-Schlieker W, Felix R, Wiedenmann B. Magnetic resonance cholangiopancreatography-guided unilateral endoscopic stent placement for Klatskin tumors. Gastrointest Endosc. 2001;53:40–46
  12. Born P, Rosch T, Willkomm G, et al. Initial experience with a new Yamakawa-type prosthesis for long-term percutaneous transhepatic drainage. Endoscopy. 1999;31:748–750
  13. Kaufman SL. Percutaneous palliation of unresectable pancreatic cancer. Surg Clin North Am. 1995;75:989–999
  14. Schlitt HJ, Weimann A, Klempnauer J, et al. Peripheral hepatojejunostomy as palliative treatment for irresectable malignant tumors of the liver hilum. Ann Surg. 1999;229:181–186
  15. Jarnagin WR, Fong Y, DeMatteo RP, et al. Staging, resectability, and outcome in 225 patients with hilar cholangiocarcinoma. Ann Surg. 2001;234:507–517
  16. Miyazaki M, Ito H, Nakagawa K, et al. Aggressive surgical approaches to hilar cholangiocarcinoma: hepatic or local resection?. Surgery. 1998;123:131–136
  17. Mittal B, Deutsch M, Iwatsuki S. Primary cancers of the extrahepatic biliary passages. Int J Radiat Oncol Biol Phys. 1985;11:849–855
  18. Otto G, Thies J, Hoppe-Lotichius M, Bittinger F, Pitton MB, Hadian A. Hiläres Cholangiokarzinom – Ergebnisse bei En-bloc-Resektion von Tumor und Leber. Chirurg. 2004;75(1):59–65
  19. Nishio H, Hidalgo E, Hamady ZZ, et al. Left hepatic trisectionectomy for hepatobiliary malignancy: results and an appraisal of its current role. Ann Surg. 2005;242(2):267–275
  20. Bismuth H, Nakache R, Diamond T. Management strategies in resection for hilar cholangiocarcinoma. Ann Surg. 1992;215:31–38
  21. Kosuge T, Yamamoto J, Shimada K, Yamasaki S, Makuuchi M. Improved surgical results for hilar cholangiocarcinoma with procedures including major hepatic resection. Ann Surg. 1999;230:663–671
  22. Kitagawa Y, Nagino M, Kamiya J, et al. Lymph node metastasis from hilar cholangiocarcinoma: audit of 110 patients who underwent regional and paraaortic node dissection. Ann Surg. 2001;233:385–392
  23. Tojima Y, Nagino M, Ebata T, Uesaka K, Kamiya J, Nimura Y. Immunohistochemically demonstrated lymph node micrometastasis and prognosis in patients with otherwise node-negative hilar cholangiocarcinoma. Ann Surg. 2003;237:201–207
  24. De Vreede I, Steers JL, Burch PA, et al. Prolonged disease-free survival after orthotopic liver transplantation plus adjuvant chemoirradiation for cholangiocarcinoma. Liver Transpl. 2000;6:309
  25. Rea DJ, Heimbach JK, Rosen CB, et al. Liver transplantation with neoadjuvant chemoradiation is more effective than resection for hilar cholangiocarcinoma. Ann Surg. 2005;242(3):451–458
  26. Heimbach JK, Gores GJ, Nagorney DM, Rosen CB. Liver transplantation for perihilar cholangiocarcinoma after aggressive neoadjuvant therapy: a new paradigm for liver and biliary malignancies?. Surgery. 2006;140(3):331–334
  27. Sudan D, DeRoover A, Chinnakotla S, et al. Radiochemotherapy and transplantation allow long-term survival for nonresectable hilar cholangiocarcinoma. Am J Transplant. 2002;2(8):774–779
  28. Malago M, Rogiers X, Broelsch CE. Reduced-size hepatic allografts. Annu Rev Med. 1995;46:507–512
  29. Yamaoka Y, Washida M, Honda K, et al. Liver transplantation using a right lobe graft from a living related donor. Transplantation. 1994;57(7):1127–1130
  30. Kadry Z, Mullhaupt B, Renner EL, et al. Living donor liver transplantation and tolerance: a potential strategy in cholangiocarcinoma. Transplantation. 2003;76:1003
  31. Lee SG, Park KM, Hwang S, et al. Adult-to-adult living donor liver transplantation at the Asan Medical Center, Korea. Asian J Surg. 2002;25:277
  32. Takatsuki M, Uemoto S, Inomata Y, et al. Living-donor liver transplantation for Caroli's disease with intrahepatic adenocarcinoma. J Hepatobiliary Pancreat Surg. 2001;8:284
  33. Varotti G, Gondolesi GE, Roayaie S, et al. Combined adult-to-adult living donor right lobe liver transplantation and pancreatoduodenectomy for distal bile duct adenocarcinoma in a patient with primary sclerosing cholangitis. J Am Coll Surg. 2003;197:765
  34. Jonas S, Mittler J, Pascher A, et al. Extended indications in living-donor liver transplantation: bile duct cancer. Transplantation. 2005;80:S101–S104

PII: S0748-7983(07)00547-1

doi: 10.1016/j.ejso.2007.09.024

European Journal of Surgical Oncology
Volume 34, Issue 3 , Pages 263-271 , March 2008