Tissue inhibitor of metalloproteinase-2 G-418C polymorphism is associated with an increased risk of gastric cancer in a Chinese population

Yang, L.; Gu, H.-J.; Zhu, H.-J.; Sun, Q.-M.; Cong, R.-H.; Zhou, B.; Tang, N.-P.; Wang, B.

doi:10.1016/j.ejso.2007.09.003

« Previous Next »European Journal of Surgical Oncology
Volume 34, Issue 6 , Pages 636-641, June 2008

Tissue inhibitor of metalloproteinase-2 G-418C polymorphism is associated with an increased risk of gastric cancer in a Chinese population

L. Yang
- Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, Jiangsu Province, China
- Department of General Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
- These authors have contributed equally to this work.
H.-J. Gu
- Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, Jiangsu Province, China
- These authors have contributed equally to this work.
H.-J. Zhu
- Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, Jiangsu Province, China
- These authors have contributed equally to this work.
Q.-M. Sun
- Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, Jiangsu Province, China
R.-H. Cong
- Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, Jiangsu Province, China
B. Zhou
- Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, Jiangsu Province, China
N.-P. Tang
- Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, Jiangsu Province, China
B. Wang
- Key Laboratory of Reproductive Medicine, Department of Pharmacology, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, Jiangsu Province, China
- Corresponding author. Department of Pharmacology, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, Jiangsu Province, China. Tel./fax: +86 25 86862884.

Accepted 4 September 2007.

Abstract

Aims

To examine the effect of the TIMP-2 G-418C polymorphism on gastric cancer risk.

Methods

We conducted a hospital-based, case–control study using polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) method in 412 individuals (206 gastric cancer patients and 206 age, sex matched cancer-free controls).

Results

The genotype and allele frequencies were significantly different (P=0.007 and 0.005, respectively) between cases and controls. Further analysis showed that the variant TIMP-2 genotypes (CC+GC) had a 51% increased risk of gastric cancer compared with GG [adjusted odds ratio (OR) 1.51, 95% confidence interval (CI) 1.00–2.26, P=0.049]. The elevated gastric cancer risk was especially evident in younger individuals (age<58 years old) (adjusted OR 2.21, 95% CI 1.18–4.16) and smokers (adjusted OR 2.61, 95% CI 1.01–6.72). However, no significant association was observed between the variant genotypes and clinicopathological features of gastric cancer.