European Journal of Surgical Oncology
Volume 33, Issue 1 , Pages 33-38 , February 2007

Determination of sentinel lymph node (SLN) status in primary breast cancer by prospective use of immunohistochemistry increases the rate of micrometastases and isolated tumour cells: Analysis of 174 patients after SLN biopsy

  • L. Rydén

      Affiliations

    • Department of Surgery, Institution of Clinical Science, Lund University Hospital, SE-221 85 Lund, Sweden
    • Corresponding Author InformationCorresponding author. Fax: +46 (0)46 14 72 98.
    • ,
  • G. Chebil

      Affiliations

    • Department of Pathology, Helsingborg Hospital, Helsingborg, Sweden
    • ,
  • L. Sjöström

      Affiliations

    • Department of Pathology, Helsingborg Hospital, Helsingborg, Sweden
    • ,
  • R. Pawlowski

      Affiliations

    • Department of Surgery, Helsingborg Hospital, Helsingborg, Sweden
    • ,
  • P.-E. Jönsson

      Affiliations

    • Department of Surgery, Helsingborg Hospital, Helsingborg, Sweden
    • Department of Surgery, Malmö University Hospital, Malmö, Sweden

,Accepted 8 November 2006.

References 

  1. Lyman GH, Giuliano AE, Somerfield MR, et al. American Society of Clinical Oncology guideline recommendations for sentinel lymph node biopsy in early-stage breast Cancer 10. J Clin Oncol. 2005;23:7703–7720
  2. Smeets A, Christiaens MR. Implications of the sentinel lymph node procedure for local and systemic adjuvant treatment. Curr Opin Oncol. 2005;17:539–544
  3. Recht A, Houlihan MJ. Axillary lymph nodes and breast cancer: a review. Cancer. 1995;76:1491–1512
  4. Veronesi U, Paganelli G, Viale G, et al. A randomized comparison of sentinel-node biopsy with routine axillary dissection in breast cancer. N Engl J Med. 2003;349:546–553
  5. Singletary SE, Allred C, Ashley P, et al. Revision of the American Joint Committee on Cancer Staging System for Breast Cancer. J Clin Oncol. 2002;20:3628–3636
  6. Cserni G, Amendoeira I, Apostolikas N, et al. Discrepancies in current practice of pathological evaluation of sentinel lymph nodes in breast cancer. Results of a questionnaire based survey by the European Working Group for Breast Screening Pathology. J Clin Pathol. 2004;57:695–701
  7. Wilkinson EJ, Hause LL, Hoffman RG, et al. Occult axillary lymph node metastases in invasive breast carcinoma: characteristics of the primary tumor and significance of the metastases. Pathol Annu. 1982;17:67–91
  8. Colleoni M, Rotmensz N, Peruzzotti G, et al. Size of breast cancer metastases in axillary lymph nodes: clinical relevance of minimal lymph node involvement. J Clin Oncol. 2005;23:1379–1389
  9. Chagpar A, Middleton LP, Sahin AA, et al. Clinical outcome of patients with lymph node-negative breast carcinoma who have sentinel lymph node micrometastases detected by immunohistochemistry. Cancer. 2005;103:1581–1586
  10. Calhoun KE, Hansen NM, Turner RR, Giuliano AE. Nonsentinel node metastases in breast cancer patients with isolated tumor cells in the sentinel node: implications for completion axillary node dissection. Am J Surg. 2005;190:588–591
  11. Davidson NE, Morrow M, Kopans DB, Koerner FC. Case records of the Massachusetts General Hospital. Case 35-2005. A 56-year-old woman with breast cancer and isolated tumor cells in a sentinel lymph node. N Engl J Med. 2005;353:2177–2185
  12. de Widt-Levert L, Tjan-Heijnen V, Bult P, et al. Stage migration in breast cancer: surgical decisions concerning isolated tumour cells and micro-metastases in the sentinel lymph node. Eur J Surg Oncol. 2003;29:216–220
  13. Viale G, Maiorano E, Pruneri G, et al. Predicting the risk for additional axillary metastases in patients with breast carcinoma and positive sentinel lymph node biopsy. Ann Surg. 2005;241:319–325
  14. Turner RR, Ollila DW, Stern S, Giuliano AE. Optimal histopathologic examination of the sentinel lymph node for breast carcinoma staging. Am J Surg Pathol. 1999;23:263–267
  15. Bergkvist L, Frisell J. Multicentre validation study of sentinel node biopsy for staging in breast cancer. Br J Surg. 2005;92:1221–1224
  16. Cserni G, Gregori D, Merletti F, et al. Meta-analysis of non-sentinel node metastases associated with micrometastatic sentinel nodes in breast cancer. Br J Surg. 2004;91:1245–1252
  17. Fan YG, Tan YY, Wu CT, et al. The effect of sentinel node tumor burden on non-sentinel node status and recurrence rates in breast cancer. Ann Surg Oncol. 2005;12:705–711
  18. Leidenius MH, Vironen JH, Riihela MS, et al. The prevalence of non-sentinel node metastases in breast cancer patients with sentinel node micrometastases. Eur J Surg Oncol. 2005;31:13–18
  19. Klevesath MB, Bobrow LG, Pinder SE, Purushotham AD. The value of immunohistochemistry in sentinel lymph node histopathology in breast cancer. Br J Cancer. 2005;92:2201–2205
  20. Schreiber RH, Pendas S, Ku NN, et al. Microstaging of breast cancer patients using cytokeratin staining of the sentinel lymph node. Ann Surg Oncol. 1999;6:95–101
  21. Van Zee KJ, Manasseh D-ME, Bevilacqua JLB, et al. A Nomogram for Predicting the Likelihood of Additional Nodal Metastases in Breast Cancer Patients With a Positive Sentinel Node Biopsy. Ann Surg Oncol. 2003;10:1140–1151
  22. Cserni G. Further axillary metastases associated with isolated tumor cells in sentinel lymph nodes of breast cancer patients. Ann Surg. 2006;243:287;[author reply 287]
  23. Langer I, Marti WR, Guller U, et al. Axillary recurrence rate in breast cancer patients with negative sentinel lymph node (SLN) or SLN micrometastases: prospective analysis of 150 patients after SLN biopsy. Ann Surg. 2005;241:152–158

PII: S0748-7983(06)00458-6

doi: 10.1016/j.ejso.2006.11.007

European Journal of Surgical Oncology
Volume 33, Issue 1 , Pages 33-38 , February 2007

Article Tools