European Journal of Surgical Oncology
Volume 33, Issue 1 , Pages 16-22 , February 2007

Correlation between molecular metastases in sentinel lymph nodes of breast cancer patients and St Gallen risk category

  • P. Gimbergues

      Affiliations

    • Department of Surgery, Centre Jean Perrin, Clermont-Ferrand, France
    • ,
  • M.M. Dauplat

      Affiliations

    • Department of Pathology, Centre Jean Perrin, Clermont-Ferrand, France
    • ,
  • A. Cayre

      Affiliations

    • Department of Pathology, Centre Jean Perrin, Clermont-Ferrand, France
    • ,
  • X. Durando

      Affiliations

    • Department of Clinical Oncology, Centre Jean Perrin, Clermont-Ferrand, France
    • ,
  • G. Le Bouedec

      Affiliations

    • Department of Surgery, Centre Jean Perrin, Clermont-Ferrand, France
    • ,
  • F. Finat-Duclos

      Affiliations

    • Laboratory of Molecular Genetic Diagnosis, Centre Jean Perrin, Clermont-Ferrand, France
    • ,
  • G. Portefaix

      Affiliations

    • Haematology Laboratory, Centre Jean Perrin, Clermont-Ferrand, France
    • ,
  • F. Kwiatkowski

      Affiliations

    • Department of Statistics and Medical Communication, Centre Jean Perrin, Clermont-Ferrand, France
    • ,
  • J. Dauplat

      Affiliations

    • Department of Surgery, Centre Jean Perrin, Clermont-Ferrand, France
    • ,
  • F. Penault-Llorca

      Affiliations

    • Department of Pathology, Centre Jean Perrin, Clermont-Ferrand, France
    • ,
  • A. Tchirkov

      Affiliations

    • Department of Radiotherapy, Centre Jean Perrin, 58, rue Montalembert—BP 392, 63011 Clermont-Ferrand Cedex 1, France
    • Corresponding Author InformationCorresponding author. Tel.: +33 4 73 27 81 42; fax: +33 4 73 27 81 25.

,Accepted 14 September 2006.

References 

  1. Harris JR, Lippman ME, Morrow M, Hellman S. Diseases of breast. Philadelphia: Lippicott-Raven; 1995;
  2. Veronesi U, Paganelli G, Galimberti V, et al. Sentinel-node biopsy to avoid axillary dissection in breast cancer with clinically negative lymph-nodes. Lancet. 1997;349:1864–1867
  3. Smith BL. Approaches to breast-cancer staging. N Engl J Med. 2000;342:580–581
  4. International (Ludwig) Breast Cancer Study Group . Prognostic importance of occult axillary lymph node micrometastases from breast cancers. Lancet. 1990;335:1565–1568
  5. Cote RJ, Peterson HF, Chaiwun B, et al. Role of immunohistochemical detection of lymph-node metastases in management of breast cancer. International Breast Cancer Study Group. Lancet. 1999;354:896–900
  6. Noguchi S, Aihara T, Nakamori S, et al. The detection of breast carcinoma micrometastases in axillary lymph nodes by means of reverse transcriptase polymerase chain reaction. Cancer. 1994;74:1600–1995
  7. Min CJ, Tafra L, Verbanac KM. Identification of superior markers for polymerase chain reaction detection of breast cancer metastases in sentinel lymph nodes. Cancer Res. 1998;58:4581–4584
  8. Mitas M, Mikhitarian K, Walters C, et al. Quantitative real-time RT–PCR detection of breast cancer micrometastasis using a multigene marker panel. Int J Cancer. 2001;93:162–171
  9. Backus J, Laughlin T, Wang Y, et al. Identification and characterization of optimal gene expression markers for detection of breast cancer metastasis. J Mol Diagn. 2005;7:327–336
  10. Bostick PJ, Huynh KT, Sarantou T, et al. Detection of metastases in sentinel lymph nodes of breast cancer patients by multiple-marker RT–PCR. Int J Cancer. 1998;79:645–651
  11. Lockett MA, Baron PL, O'Brien PH, et al. Detection of occult breast cancer micrometastases in axillary lymph nodes using a multimarker reverse transcriptase-polymerase chain reaction panel. J Am Coll Surg. 1998;187:9–16
  12. Manzotti M, Dell'Orto P, Maisonneuve P, Zurrida S, Mazzarol G, Viale G. Reverse transcription-polymerase chain reaction assay for multiple mRNA markers in the detection of breast cancer metastases in sentinel lymph nodes. Int J Cancer. 2001;95:307–312
  13. Marchetti A, Buttitta F, Bertacca G, et al. M RNA markers of breast cancer nodal metastases: comparison between mammaglobin and carcinoembryonic antigen in 248 patients. J Pathol. 2001;195:186–190
  14. Sakaguchi M, Virmani A, Dudak MW, et al. Clinical relevance of reverse transcriptase-polymerase chain reaction for the detection of axillary lymph node metastases in breast cancer. Ann Surg Oncol. 2003;10:117–125
  15. Nissan A, Jager D, Roystacher M, et al. Multimarker RT–PCR assay for the detection of minimal residual disease in sentinel lymph nodes of breast cancer patients. Br J Cancer. 2006;94:681–685
  16. Gillanders WE, Mikhitarian K, Hebert R, et al. Molecular detection of micrometastatic breast cancer in histopathology-negative axillary lymph nodes correlates with traditional predictors prognosis. Ann Surg. 2004;239:828–840
  17. Mikhitarian K, Martin RH, Mitas M, et al. et al Molecular analysis improves sensitivity of breast sentinel lymph node biopsy: results of a multi-institutional prospective cohort study. Surgery. 2005;138:474–481
  18. Hughes SJ, Xi L, Raja S, et al. A rapid, fully automated, molecular-based assay accurately analyzes sentinel lymph nodes for the presence of metastatic breast cancer. Ann Surg. 2006;243:389–398
  19. Dell'orto P, Olivia Biasi M, Del Curto B, Zurrida S, Galimberti V, Viale G. Assessing the status of axillary sentinel lymph nodes of breast carcinoma patients by a real-time quantitative RT–PCR assay for mammaglobin 1 mRNA. Breast Cancer Res Treat. 2006;98:185–190
  20. Noguchi S, Aihara T, Motomura K, Inaji H, Imaoka S, Koyama H. Histologic characteristics of breast cancers with occult lymph node metastases detected by keratin 19 mRNA reverse-transcriptase polymerase chain reaction. Cancer. 1996;78:1235–1240
  21. Masuda N, Tamaki Y, Sakita I, et al. Clinical significance of micrometastases in axillary lymph nodes assessed by reverse transcription-polymerase chain reaction in breast cancer patients. Clin Cancer Res. 2000;6:4176–4185
  22. Singletary SE, Allred C, Ashley P, et al. Revision of the American Joint Committee on Cancer staging system breast cancer. J Clin Oncol. 2002;20:3628–3636
  23. Singletary SE, Allred C, Ashley P, et al. Staging system for breast cancer: revisions for the 6th edition of the AJCC Cancer Staging Manual. Surg Clin North Am. 2003;83:803–819
  24. Goldhirsch A, Glick JH, Gelber RD, Coates AS, Thürlimann B, Senn H-J Panel Members. Meeting Highlights: International Expert Consensus on the Primary Therapy of Early Breast Cancer 2005. Ann Oncol. 2005;16:1569–1583
  25. Gerhard M, Juhl H, Kalthoff H, Scheirber HW, Wagener C, Neumaier M. Specific detection of carcinoembryonic antigen-expressing tumor cells in bone marrow aspirates by polymerase chain reaction. J Clin Oncol. 1994;12:725–729
  26. Tchirkov A, Giollant M, Tavernier F, et al. Interphase cytogenetics and competitive RT–PCR for residual disease monitoring in patients with chronic myeloid leukemia during interferon-a therapy. Br J Haematol. 1998;101:552–557
  27. Kwiatkowski F, Girard M, Hacene K, Berlie J. Sem: a suitable statistical software adapted for research in oncology. Bull Cancer. 2000;87:715–721
  28. Goldhirsch A, Wood WC, Gelber RD, Coates AS, Thurlimann B, Senn HJ. Meeting highlights: updated international expert consensus on the primary therapy of early breast cancer. J Clin Oncol. 2003;21:3357–3365

PII: S0748-7983(06)00337-4

doi: 10.1016/j.ejso.2006.09.013

European Journal of Surgical Oncology
Volume 33, Issue 1 , Pages 16-22 , February 2007

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