Familial clustering in subgroups of gastric cancer stratified by histology, age group and location

Eto, K.; Ohyama, S.; Yamaguchi, T.; Wada, T.; Suzuki, Y.; Mitsumori, N.; Kashiwagi, H.; Anazawa, S.; Yanaga, K.; Urashima, M.

doi:10.1016/j.ejso.2006.04.005

« Previous Next »European Journal of Surgical Oncology
Volume 32, Issue 7 , Pages 743-748, September 2006

Familial clustering in subgroups of gastric cancer stratified by histology, age group and location

K. Eto
- Department of Surgery, The Cancer Institute Hospital, Toshima-ku, Tokyo, Japan
- Department of Surgery, Jikei University School of Medicine, Nishi-shimbashi 3-25-8, Minato-ku, Tokyo 105-8461, Japan
S. Ohyama
- Department of Surgery, The Cancer Institute Hospital, Toshima-ku, Tokyo, Japan
T. Yamaguchi
- Department of Surgery, The Cancer Institute Hospital, Toshima-ku, Tokyo, Japan
T. Wada
- Health Science Center, Jikei University School of Medicine, Nishi-shimbashi 3-25-8, Minato-ku, Tokyo 105-8461, Japan
Y. Suzuki
- Department of Surgery, Jikei University School of Medicine, Nishi-shimbashi 3-25-8, Minato-ku, Tokyo 105-8461, Japan
N. Mitsumori
- Department of Surgery, Jikei University School of Medicine, Nishi-shimbashi 3-25-8, Minato-ku, Tokyo 105-8461, Japan
H. Kashiwagi
- Department of Surgery, Jikei University School of Medicine, Nishi-shimbashi 3-25-8, Minato-ku, Tokyo 105-8461, Japan
S. Anazawa
- Department of Surgery, Jikei University School of Medicine, Nishi-shimbashi 3-25-8, Minato-ku, Tokyo 105-8461, Japan
K. Yanaga
- Department of Surgery, Jikei University School of Medicine, Nishi-shimbashi 3-25-8, Minato-ku, Tokyo 105-8461, Japan
M. Urashima
- Division of Clinical Research and Development, Jikei University School of Medicine, Nishi-shimbashi 3-25-8, Minato-ku, Tokyo 105-8461, Japan
- Corresponding author. Tel.: +81 3 3433 1111, ext. 2405; fax: +81 3 5400 1250.

Accepted 5 April 2006.

Abstract

Aim

To assess the risk of gastric cancer in a Japanese patient population with the disease by stratification with histology, age, tumour location and the association with family history of gastric or non-gastric tumours.

Methods

A retrospective analysis of 1400 consecutive patients with gastric cancer and 13,467 age- and gender-matched controls from a pre-recorded database using conditional logistic regression models.

Results

Young patients (≤43years of age) with gastric cancer of intestinal type had a strong association with family history of gastric cancer in first degree-relatives (OR=12.5). Moreover, when a history of gastric cancer was observed in both parents, there was an increased risk of gastric cancer intestinal type (OR=7.8), more commonly in the proximal and mid-stomach. In contrast, there was an increased risk of diffuse-type cancer when both parents suffered non-gastric cancers (OR=2.1).

Conclusion

These data suggest that the degree of familial clustering differ in gastric cancer subgroups stratified by histology, age, and stomach location in this Japanese population.

Keywords: Gastric, Carcinoma, Disease clustering, Family, Aggregation, Case-control study